Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

(2020) Julia Minderjahn et al.   Nature Communications

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non–Small Cell Lung Carcinoma

(2020) Shujie Song et al.   MOLECULAR CANCER RESEARCH

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines

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CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

(2019) Yibo Xue et al.   Nature Communications

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

(2019) Yibo Xue et al.   Nature Communications

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting

(2019) Joshua Pan et al.   NATURE GENETICS

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4

(2019) Fangjian Gao et al.   MOLECULAR CELL

Inhibition of MYC by the SMARCB1 tumor suppressor

(2019) April M. Weissmiller et al.   Nature Communications

Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies

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Frequent loss of claudin-4 expression in dedifferentiated and undifferentiated endometrial carcinomas

(2018) Basile Tessier-Cloutier et al.   HISTOPATHOLOGY

Functions of EpCAM in physiological processes and diseases (Review)

(2018) Li Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)

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The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

(2018) Ines Garces de los Fayos Alonso et al.   Cancers

Histone deacetylase inhibitors synergizes with catalytic inhibitors of EZH2 to exhibit anti-tumor activity in small cell carcinoma of the ovary, hypercalcemic type

(2018) Yemin Wang et al.   MOLECULAR CANCER THERAPEUTICS

The role of AP-1 in self-sufficient proliferation and migration of cancer cells and its potential impact on an autocrine/paracrine loop

(2018) Sherif Abd El-Fattah Ibrahim et al.   Oncotarget

RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management

(2018) Kevin A. Kovalchik et al.   JOURNAL OF PROTEOME RESEARCH

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

(2018) Brittany C. Michel et al.   NATURE CELL BIOLOGY

The chromatin accessibility landscape of primary human cancers

(2018) M. Ryan Corces et al.   SCIENCE

Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type

(2017) Douglas I. Lin et al.   GYNECOLOGIC ONCOLOGY

Clinical, morphological and immunohistochemical evidence that small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ-cell neoplasm

(2017) W Glenn McCluggage et al.   HISTOPATHOLOGY

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type

(2017) Yemin Wang et al.   JOURNAL OF PATHOLOGY

Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease

(2017) Malik Quasir Mahmood et al.   MEDICAL ONCOLOGY

Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas

(2017) Inga-Marie Schaefer et al.   MODERN PATHOLOGY

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

(2017) Thomas Vierbuchen et al.   MOLECULAR CELL

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

(2017) Burak H. Alver et al.   Nature Communications

Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma

(2017) Edward Britton et al.   PLoS Genetics

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

(2017) Timothy W R Kelso et al.   eLife

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small-cell carcinoma of the ovary, hypercalcaemic type distinguishes these tumours from their mimics

(2016) Blaise A Clarke et al.   HISTOPATHOLOGY

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

(2016) Radhika Mathur et al.   NATURE GENETICS

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

(2015) Anthony N Karnezis et al.   JOURNAL OF PATHOLOGY

Using Peptide-Level Proteomics Data for Detecting Differentially Expressed Proteins

(2015) Tomi Suomi et al.   JOURNAL OF PROTEOME RESEARCH

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes

(2015) Jesse R. Raab et al.   PLoS Genetics

BRG1/SMARCA4 Inactivation Promotes Non-Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization

(2014) T. Orvis et al.   CANCER RESEARCH

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development

(2014) Darmood Wei et al.   MOLECULAR CANCER RESEARCH

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

(2014) Pilar Ramos et al.   NATURE GENETICS

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

(2014) Leora Witkowski et al.   NATURE GENETICS

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary

(2014) Petar Jelinic et al.   NATURE GENETICS

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AP-1/c-Jun transcription factors: Regulation and function in malignant melanoma

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Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions

(2013) Stephanie A Morris et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ovarian small cell carcinoma of hypercalcemic type – evidence of germline origin and smarca4 gene inactivation. a pilot study

(2013) Jolanta Kupryjańczyk et al.   POLISH JOURNAL OF PATHOLOGY

Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

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An integrated encyclopedia of DNA elements in the human genome

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Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature

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Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1

(2011) G. Hu et al.   GENOME RESEARCH

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

A Dominant-Negative c-jun Mutant Inhibits Lung Carcinogenesis in Mice

(2010) J. W. Tichelaar et al.   Cancer Prevention Research

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Useful Immunohistochemical Markers of Tumor Differentiation

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