Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori
Authors
Keywords
-
Journal
Toxins
Volume 12, Issue 11, Pages 729
Publisher
MDPI AG
Online
2020-11-24
DOI
10.3390/toxins12110729
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study
- (2020) Wenhao Cheng et al. International Journal of Analytical Chemistry
- In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside
- (2020) Cheng Wang et al. BMC Pharmacology & Toxicology
- Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses
- (2019) Longfei Lin et al. Cells
- HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum –Induced Liver Injury in Humans
- (2019) Chaopeng Li et al. HEPATOLOGY
- Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
- (2019) Rong-Rong Li et al. MOLECULES
- Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges
- (2019) Yi Liu et al. Frontiers in Pharmacology
- In Vitro and in Vivo Studies of the Electrophilicity of Physcion and its Oxidative Metabolites
- (2018) Xiaotong Qin et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Transcriptome analysis to assess the cholestatic hepatotoxicity induced by Polygoni Multiflori Radix: Up-regulation of key enzymes of cholesterol and bile acid biosynthesis
- (2018) Li-Long Jiang et al. Journal of Proteomics
- Emodin induces liver injury by inhibiting the key enzymes of FADH/NADPH transport in rat liver
- (2018) Xiaowei Yang et al. Toxicology Research
- Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
- (2018) Yue Liu et al. Frontiers in Pharmacology
- Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
- (2018) Miao Zhang et al. Frontiers in Pharmacology
- Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway
- (2018) Xiaoxv Dong et al. ONCOLOGY REPORTS
- Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2
- (2018) Lili Wu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine
- (2018) Jing Wei et al. JOURNAL OF ETHNOPHARMACOLOGY
- Pharmacokinetic studies unveiled the drug–drug interaction between trans-2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix
- (2018) Yanchao Xing et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1
- (2017) Deng-Ke Li et al. Evidence-based Complementary and Alternative Medicine
- Hepatoprotection and hepatotoxicity of Heshouwu , a Chinese medicinal herb: Context of the paradoxical effect
- (2017) Hongliang Li et al. FOOD AND CHEMICAL TOXICOLOGY
- Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids
- (2017) Dong-Sheng Zhao et al. FOOD AND CHEMICAL TOXICOLOGY
- Rapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC–MS/MS
- (2017) Linlin Wang et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes
- (2017) Li Kang et al. TOXICOLOGY IN VITRO
- Effect of a stilbene glycoside‑rich extract from Polygoni Multiflori Radix on experimental non‑alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis
- (2017) Zhaohuan Lou et al. Experimental and Therapeutic Medicine
- Novel functional polysaccharides from Radix Polygoni Multiflori water extracted residue: Preliminary characterization and immunomodulatory activity
- (2016) Qing Zhang et al. CARBOHYDRATE POLYMERS
- Ultrasonic-assisted extraction, structure and antitumor activity of polysaccharide from Polygonum multiflorum
- (2016) Weili Zhu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Bile acids in drug induced liver injury: Key players and surrogate markers
- (2016) Heiko S. Schadt et al. Clinics and Research in Hepatology and Gastroenterology
- Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata
- (2016) Dan Gao et al. Frontiers in Pharmacology
- Simultaneous determination and pharmacokinetic study of P-hydroxybenzaldehyde, 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside, emodin-8-O-β-d-glucopyranoside, and emodin in rat plasma by liquid chromatography tandem mass spectrometry after oral administration of Polygonum multiflorum
- (2015) Longfei Lin et al. Analytical Methods
- Liver Damage Associated withPolygonum multiflorumThunb.: A Systematic Review of Case Reports and Case Series
- (2015) Xiang Lei et al. Evidence-based Complementary and Alternative Medicine
- RUCAM in Drug and Herb Induced Liver Injury: The Update
- (2015) Gaby Danan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats
- (2015) Yanbin Shi et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review
- (2015) Longfei Lin et al. JOURNAL OF ETHNOPHARMACOLOGY
- Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats
- (2015) Jiang Ma et al. JOURNAL OF ETHNOPHARMACOLOGY
- Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats
- (2015) Xin Di et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Inflammatory stress potentiates emodin-induced liver injury in rats
- (2015) Can Tu et al. Frontiers in Pharmacology
- Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study
- (2015) Qin Dong et al. Frontiers in Pharmacology
- CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum
- (2014) K.F. Ma et al. GENETICS AND MOLECULAR RESEARCH
- Molecular mechanisms of hepatic apoptosis
- (2014) K Wang Cell Death & Disease
- Eighteen cases of liver injury following ingestion of Polygonum multiflorum
- (2013) Huihui Dong et al. COMPLEMENTARY THERAPIES IN MEDICINE
- Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: Application to a drug–drug interaction study in Radix Polygoni Multiflori
- (2013) Jiang Ma et al. JOURNAL OF ETHNOPHARMACOLOGY
- Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC–ESI–MS/MS
- (2013) Ling Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Pharmacokinetics of oral administration of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum multiflorum in beagle dogs
- (2012) Jianxin Chen African Journal of Pharmacy and Pharmacology
- Chemical characterization and immunostimulatory effects of a polysaccharide from Polygoni Multiflori Radix Praeparata in cyclophosphamide-induced anemic mice
- (2012) Qin Chen et al. CARBOHYDRATE POLYMERS
- Pharmacokinetics of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS
- (2012) Ying-Yong Zhao et al. JOURNAL OF SEPARATION SCIENCE
- Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells
- (2012) Zenghui Teng et al. PLoS One
- Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin
- (2012) Wei Liu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb
- (2011) Kyoung Ah Jung et al. Gut and Liver
- Species and Gender Differences Affect the Metabolism of Emodin via Glucuronidation
- (2010) Wei Liu et al. AAPS Journal
- Reactivation of Pulmonary Tuberculosis in a Patient with Polygonum multiflorum Thunb-Induced Hepatitis
- (2010) Hyun Chin Cho et al. Gut and Liver
- Sensitive and robust UPLC–MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide
- (2010) Wei Liu et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry
- (2010) Zhitao Liang et al. Chinese Medicine
- Acute Hepatitis Associated With the Use of an Herbal Supplement (Polygonum Multiflorum) Mimicking Iron-overload Syndrome
- (2009) Ashley R. Laird et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats**Chi-Sheng Shia and Yu-Chi Hou contributed equally to this work.
- (2009) Chi-Sheng Shia et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Summary on Quality Control of TCMs in Chinese Pharmacopoeia (2010 version)
- (2009) ZZ Qian PLANTA MEDICA
- Structural elucidation ofin vitrometabolites of emodin by liquid chromatography-tandem mass spectrometry
- (2008) Rui Song et al. BIOMEDICAL CHROMATOGRAPHY
- Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease
- (2008) H.Q. Lin et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Cellular and Molecular Mechanisms of Liver Injury
- (2008) Harmeet Malhi et al. GASTROENTEROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started