Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia

Neuroprotective Mechanisms of Calycosin Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

(2018) Yong Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice

(2018) Yongmei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats

(2018) Nathanael Matei et al.   JOURNAL OF NEUROSCIENCE

Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway

(2018) Jun Yang et al.   NEUROCHEMICAL RESEARCH

Near-infrared spectroscopy for rapid and simultaneous determination of five main active components in rhubarb of different geographical origins and processing

(2018) Xue Jintao et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion

(2018) Yongmei Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Simple and Sensitive Liquid Chromatography with Tandem Mass Spectrometric Method for the Simultaneous Determination of Anthraquinone Glycosides and Their Aglycones in Rat Plasma: Application to a Pharmacokinetic Study of Rumex acetosa Extract

(2018) Hossain Ullah et al.   Pharmaceutics

Outcome after stroke thrombolysis in patients >80 years treated within 3 hours vs >3–4.5 hours

(2017) Niaz Ahmed et al.   NEUROLOGY

Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO

(2017) Devin W. McBride et al.   Translational Stroke Research

Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats

(2016) Chung-Ping Yu et al.   BIOMEDICAL CHROMATOGRAPHY

Comparisons between Garcia, Modo, and Longa rodent stroke scales: Optimizing resource allocation in rat models of focal middle cerebral artery occlusion

(2016) Salam P. Bachour et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Pharmacokinetics and pharmacodynamics study of rhein treating renal fibrosis based on metabonomics approach

(2016) Hao Sun et al.   PHYTOMEDICINE

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

(2016) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice

(2016) Gary P. Morris et al.   PLoS One

Hyperbaric oxygen preconditioning attenuates hemorrhagic transformation through increasing PPARγ in hyperglycemic MCAO rats

(2015) Hetao Bian et al.   EXPERIMENTAL NEUROLOGY

Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress

(2015) Maria B. Kadiiska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rhubarb extract has a protective role against radiation-induced brain injury and neuronal cell apoptosis

(2015) KUI LU et al.   Molecular Medicine Reports

Normobaric Hyperoxia Slows Blood-Brain Barrier Damage and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in Cerebral Ischemia

(2015) J. Liang et al.   STROKE

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

New and Highly Potent Antitumor Natural Products from Marine-Derived Fungi: Covering the Period from 2003 to 2012

(2013) Boris Pejin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

(2013) Julien Puyal et al.   PROGRESS IN NEUROBIOLOGY

Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR)

(2013) Niaz Ahmed   JAMA Neurology

UPLC-MS/MS performing pharmacokinetic and biodistribution studies of rhein

(2012) Hui Sun et al.   JOURNAL OF SEPARATION SCIENCE

Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats

(2012) Su-xiang Feng et al.   PHYTOTHERAPY RESEARCH

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver

(2011) Mahmoud Abu-Amara et al.   LIVER TRANSPLANTATION

How to make better use of thrombolytic therapy in acute ischemic stroke

(2011) Geoffrey A. Donnan et al.   Nature Reviews Neurology

Effective constituents in Xiexin Decoction for anti-inflammation

(2009) Bing-Liang Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats**Chi-Sheng Shia and Yu-Chi Hou contributed equally to this work.

(2009) Chi-Sheng Shia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition

(2009) Rui Song et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY