Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis

Dmrt genes participate in the development of Cajal‐Retzius cells derived from the cortical hem in the telencephalon

(2020) Takako Kikkawa et al.   DEVELOPMENTAL DYNAMICS

Cortical Malformations: Lessons in Human Brain Development

(2020) Lakshmi Subramanian et al.   Frontiers in Cellular Neuroscience

The peacefulness gene promotes aggression in Drosophila

(2019) Mahmoudreza Ramin et al.   Molecular Brain

ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome

(2019) Ya-ping Pei et al.   JOURNAL OF NEUROSCIENCE

Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction

(2019) Marta Prieto et al.   MOLECULAR PSYCHIATRY

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

(2019) Kirsty Sawicka et al.   eLife

Abnormal mTOR Activation in Autism

(2018) Kellen D. Winden et al.   Annual Review of Neuroscience

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortical progenitor biology: key features mediating proliferation versus differentiation

(2018) Ana Uzquiano et al.   JOURNAL OF NEUROCHEMISTRY

HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein

(2018) Thomas Maurin et al.   NUCLEIC ACIDS RESEARCH

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

(2018) Yue Li et al.   Nature Communications

Of Men and Mice: Modeling the Fragile X Syndrome

(2018) Regina Dahlhaus   Frontiers in Molecular Neuroscience

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling

(2018) James C. Sears et al.   Frontiers in Molecular Neuroscience

KAT6A Syndrome: genotype–phenotype correlation in 76 patients with pathogenic KAT6A variants

(2018) Joanna Kennedy et al.   GENETICS IN MEDICINE

Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins

(2018) Ethan J. Greenblatt et al.   SCIENCE

FMRP recruitment of β‐catenin to the translation pre‐initiation complex represses translation

(2018) Saviz Ehyai et al.   EMBO REPORTS

OMIM.org: leveraging knowledge across phenotype–gene relationships

(2018) Joanna S Amberger et al.   NUCLEIC ACIDS RESEARCH

Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation

(2018) Botao Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral cortex development: an outside-in perspective

(2017) Gulistan Agirman et al.   FEBS LETTERS

Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse

(2017) Cynthia L Smith et al.   NUCLEIC ACIDS RESEARCH

Multifarious Functions of the Fragile X Mental Retardation Protein

(2017) Jenna K. Davis et al.   TRENDS IN GENETICS

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

(2017) Elzbieta Kania et al.   Frontiers in Oncology

USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors

(2017) Caitlin R. Bridges et al.   Scientific Reports

Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds

(2016) Judith R. Homberg et al.   BRAIN RESEARCH BULLETIN

Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain

(2016) Louis-Jan Pilaz et al.   CURRENT BIOLOGY

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

(2016) Jacqueline N. Crawley et al.   TRENDS IN GENETICS

Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities

(2015) Cameron Mroske et al.   BMC Medical Genetics

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data

(2015) Jianguo Xia et al.   Nature Protocols

Fmr1deficiency promotes age-dependent alterations in the cortical synaptic proteome

(2015) Bin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Regulating Impaired Neurogenesis of Fragile X Syndrome Human Embryonic Stem Cells

(2015) Michael Telias et al.   STEM CELLS AND DEVELOPMENT

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth

(2014) Claire C. Homan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Diverse Genetic Landscape of Neurodevelopmental Disorders

(2014) Wen F. Hu et al.   Annual Review of Genomics and Human Genetics

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

(2014) Giorgio La Fata et al.   NATURE NEUROSCIENCE

 -Catenin interacts with APC to regulate  -catenin proteolysis and transcriptional repression of Wnt target genes

(2013) S. H. Choi et al.   GENES & DEVELOPMENT

Dmrta1 regulates proneural gene expression downstream of Pax6 in the mammalian telencephalon

(2013) Takako Kikkawa et al.   GENES TO CELLS

Inducible gene expression in postmitotic neurons by an in vivo electroporation-based tetracycline system

(2013) Tatsuya Sato et al.   JOURNAL OF NEUROSCIENCE METHODS

Wnt7a Regulates Multiple Steps of Neurogenesis

(2013) Q. Qu et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

(2013) Nathaniel W. Hartman et al.   Cell Reports

Fragile X mental retardation protein and synaptic plasticity

(2013) Michael S Sidorov et al.   Molecular Brain

SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)

(2013) Brett S Abrahams et al.   Molecular Autism

The FMRP regulon: from targets to disease convergence

(2013) Esperanza Fernández et al.   Frontiers in Neuroscience

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

FMRP Regulates the Transition from Radial Glial Cells to Intermediate Progenitor Cells during Neocortical Development

(2011) R. Saffary et al.   JOURNAL OF NEUROSCIENCE

Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome

(2011) Madeline A Lancaster et al.   NATURE MEDICINE

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner

(2011) S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells

(2010) Charles A. Easley et al.   Cellular Reprogramming

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Fragile X Protein FMRP Is Required for Homeostatic Plasticity and Regulation of Synaptic Strength by Retinoic Acid

(2010) M. E. Soden et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

(2010) Yuping Luo et al.   PLoS Genetics

Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome

(2009) F Herrera et al.   CELL DEATH AND DIFFERENTIATION

Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities

(2009) Janin Schütt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient

(2009) Motoko Maekawa et al.   NEUROSCIENCE LETTERS

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

(2009) Athanasia Spandidos et al.   NUCLEIC ACIDS RESEARCH

Co-occurring conditions associated withFMR1gene variations: Findings from a national parent survey

(2008) Donald B. Bailey et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

(2008) Jason B. Dictenberg et al.   DEVELOPMENTAL CELL

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pax6 3′ deletion results in aniridia, autism and mental retardation

(2008) L. K. Davis et al.   HUMAN GENETICS

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

(2008) J. A. Ronesi et al.   JOURNAL OF NEUROSCIENCE

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON