Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

Using human genetics to guide the repurposing of medicines

(2020) Jonas Bovijn et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

(2020) Oliver S. Burren et al.   Genome Medicine

Identification of Novel Autoantibodies Associated with Psoriatic Arthritis

(2019) Yulin Yuan et al.   Arthritis & Rheumatology

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

(2019) Yosuke Tanigawa et al.   Nature Communications

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

(2019) Paul A Lyons et al.   Nature Communications

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

(2018) John C. Taylor et al.   PHARMACOGENOMICS JOURNAL

A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica

(2018) Karol Estrada et al.   Nature Communications

An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations

(2018) Arunabha Majumdar et al.   PLoS Genetics

Evaluation and application of summary statistic imputation to discover new height-associated loci

(2018) Sina Rüeger et al.   PLoS Genetics

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

(2018) Adrià Aterido et al.   ANNALS OF THE RHEUMATIC DISEASES

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

(2017) Chao Tian et al.   Nature Communications

Eosinophils in Autoimmune Diseases

(2017) Nicola L. Diny et al.   Frontiers in Immunology

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

(2016) A Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

(2016) Michael J Ombrello et al.   ANNALS OF THE RHEUMATIC DISEASES

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Circulating levels of Th1 and Th2 chemokines in patients with ankylosing spondylitis

(2016) Jianing Wang et al.   CYTOKINE

Pathophysiology and laboratory diagnosis of pernicious anemia

(2016) Ban-Hock Toh   IMMUNOLOGIC RESEARCH

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

(2015) Robert A Power et al.   NATURE NEUROSCIENCE

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

(2015) Jin Li et al.   Nature Communications

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

A Genome-Wide Association Study of Myasthenia Gravis

(2015) Alan E. Renton et al.   JAMA Neurology

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN MOLECULAR GENETICS

Principal Component Analysis Characterizes Shared Pathogenetics from Genome-Wide Association Studies

(2014) Diana Chang et al.   PLoS Computational Biology

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Inflammatory Bowel Disease Is Associated With an Increased Risk of Melanoma: A Systematic Review and Meta-analysis

(2013) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study

(2013) Lloyd Mayer et al.   GUT

Prevalence and incidence of juvenile idiopathic arthritis: A systematic review

(2013) Sigrid Thierry et al.   JOINT BONE SPINE

Clinical Whole-Exome Sequencing for the Diagnosis of Mendelian Disorders

(2013) Yaping Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk for myasthenia gravis maps to a151Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08

(2012) Peter K. Gregersen et al.   ANNALS OF NEUROLOGY

Immune-mediated disease genetics: the shared basis of pathogenesis

(2012) Chris Cotsapas et al.   TRENDS IN IMMUNOLOGY

A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis

(2011) Michael Yellin et al.   ARTHRITIS AND RHEUMATISM

Increased Risk of Nonmelanoma Skin Cancers Among Individuals With Inflammatory Bowel Disease

(2011) Harminder Singh et al.   GASTROENTEROLOGY

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains

(2011) Christy L. Avery et al.   PLoS Genetics

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus

(2009) K. O. Kong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bayes factors for genome-wide association studies: comparison withP-values

(2008) Jon Wakefield   GENETIC EPIDEMIOLOGY