Survivin at a glance

Survivin Monoclonal Antibodies Detect Survivin Cell Surface Expression and Inhibit Tumor GrowthIn Vivo

(2018) Robert A. Fenstermaker et al.   CLINICAL CANCER RESEARCH

Cytokine Networks and Survivin Peptide-Specific Cellular Immune Responses Predict Improved Survival in Patients With Glioblastoma Multiforme

(2018) Liu Zhenjiang et al.   EBioMedicine

Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3

(2018) Nicola J. Humphry et al.   Biology Open

Correlation between E-cadherin interactions, survivin expression, and apoptosis in MDCK and ts-Src MDCK cell culture models

(2017) Janne Capra et al.   LABORATORY INVESTIGATION

Co-Delivery of Doxorubicin and Survivin shRNA-Expressing Plasmid Via Microenvironment-Responsive Dendritic Mesoporous Silica Nanoparticles for Synergistic Cancer Therapy

(2017) Zhengxiong Li et al.   PHARMACEUTICAL RESEARCH

Circulating CD9+/GFAP+/survivin+ exosomes in malignant glioma patients following survivin vaccination

(2017) Phillip M. Galbo et al.   Oncotarget

Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors

(2016) Jing Qi et al.   CANCER RESEARCH

Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β

(2016) Eva Martini et al.   CELL CYCLE

SURVIVIN as a marker for quiescent-breast cancer stem cells—An intermediate, adherent, pre-requisite phase of breast cancer metastasis

(2016) Sumit Siddharth et al.   CLINICAL & EXPERIMENTAL METASTASIS

The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator

(2016) Lucia Dunajová et al.   JOURNAL OF CELL SCIENCE

A multicenter phase II study of sepantronium bromide (YM155) plus rituximab in patients with relapsed aggressive B-cell Non-Hodgkin lymphoma

(2016) Kyriakos P. Papadopoulos et al.   LEUKEMIA & LYMPHOMA

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

(2016) Els Beghein et al.   Scientific Reports

The twisted survivin connection to angiogenesis

(2015) C. Sanhueza et al.   Molecular Cancer

Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

(2015) Ondřej Kodet et al.   Molecular Cancer

BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma

(2015) J Hagenbuchner et al.   ONCOGENE

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Survivin splice variants and their diagnostic significance

(2015) Nand K. Sah et al.   TUMOR BIOLOGY

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Survivin and YM155: How faithful is the liaison?

(2014) Anke Rauch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Phase II, multicenter, open-label, randomized study of YM155 plus docetaxel as first-line treatment in patients with HER2-negative metastatic breast cancer

(2014) Michael R. Clemens et al.   BREAST CANCER RESEARCH AND TREATMENT

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer

(2014) Aysha M Aljaberi et al.   Cancer Cell International

Immunologic response to the survivin-derived multi-epitope vaccine EMD640744 in patients with advanced solid tumors

(2014) Volker Lennerz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Functional genomics identifyBirc5/Survivinas a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors

(2014) Sandrine Siffroi-Fernandez et al.   CELL CYCLE

Combination of YM155, a Survivin Suppressant, with Bendamustine and Rituximab: A New Combination Therapy to Treat Relapsed/Refractory Diffuse Large B-cell Lymphoma

(2014) N. Kaneko et al.   CLINICAL CANCER RESEARCH

Challenges in the development of a survivin vaccine (SurVaxM) for malignant glioma

(2014) Robert A Fenstermaker et al.   Expert Review of Vaccines

Differential localization and high expression of SURVIVIN splice variants in human embryonic stem cells but not in differentiated cells implicate a role for SURVIVIN in pluripotency

(2014) Amber N. Mull et al.   Stem Cell Research

A phase 2, multicenter, open-label study of sepantronium bromide (YM155) plus docetaxel in patients with stage III (unresectable) or stage IV melanoma

(2014) Ragini Kudchadkar et al.   Cancer Medicine

A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer

(2013) R. J. Kelly et al.   ANNALS OF ONCOLOGY

Transcriptional regulation of the survivin gene

(2013) Romain Boidot et al.   MOLECULAR BIOLOGY REPORTS

Inhibition of pluripotent stem cell-derived teratoma formation by small molecules

(2013) M.-O. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress

(2012) Huda H. Al-Khalaf et al.   AGE

A novel role for survivin in erythroblast enucleation

(2012) G. Keerthivasan et al.   HAEMATOLOGICA

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

(2012) J Hagenbuchner et al.   ONCOGENE

A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer

(2011) A. W. Tolcher et al.   ANNALS OF ONCOLOGY

Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells

(2011) Qinwen Wang et al.   CANCER LETTERS

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

(2011) Rachel M.A. Barrett et al.   CELL CYCLE

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro

(2011) Rachel M.A. Barrett et al.   CELL CYCLE

Survivin Monomer Plays an Essential Role in Apoptosis Regulation

(2011) Marat S. Pavlyukov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin

(2011) A Berezov et al.   ONCOGENE

Retinoic Acid-Treated Pluripotent Stem Cells Undergoing Neurogenesis Present Increased Aneuploidy and Micronuclei Formation

(2011) Rafaela C. Sartore et al.   PLoS One

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex

(2011) A. Arockia Jeyaprakash et al.   STRUCTURE

The survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival

(2011) Anna G. Antonacopoulou et al.   CELLULAR ONCOLOGY

Survivin is released from cancer cells via exosomes

(2010) Salma Khan et al.   APOPTOSIS

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

(2010) Ting-Kuang Niu et al.   FEBS LETTERS

Liaisons between Survivin and Plk1 during Cell Division and Cell Death

(2010) Rita Colnaghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity

(2010) Haijuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing

(2009) M. Guha et al.   CANCER RESEARCH

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

(2009) Chun Hei Antonio Cheung et al.   Molecular Cancer

CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation

(2008) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

A Survivin-Ran Complex Regulates Spindle Formation in Tumor Cells

(2008) F. Xia et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination

(2008) ALO Hebb et al.   Multiple Sclerosis Journal

Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain

(2008) S. Villapol et al.   NEUROSCIENCE

Polymorphisms in the survivin gene and the risk of lung cancer

(2007) Jin Sung Jang et al.   LUNG CANCER