The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer’s disease

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

(2020) Kathleen M. Farmer et al.   Acta Neuropathologica Communications

Vitamin E and Alzheimer’s disease: what do we know so far?

(2019) Declan Browne et al.   Clinical Interventions in Aging

Control of metabolism by p53 – Cancer and beyond

(2018) Christiaan F. Labuschagne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

(2018) Samuel Kogan et al.   Cancers

Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

(2018) E. Barrio-Alonso et al.   Scientific Reports

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization

(2018) Rebeca Lapresa et al.   NEUROPHARMACOLOGY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

On the path to 2025: understanding the Alzheimer’s disease continuum

(2017) Paul S. Aisen et al.   Alzheimers Research & Therapy

Unfolded p53 in Blood as a Predictive Signature Signature of the Transition from Mild Cognitive Impairment to Alzheimer's Disease

(2017) Cristina Lanni et al.   JOURNAL OF ALZHEIMERS DISEASE

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

(2016) C Turnquist et al.   CELL DEATH AND DIFFERENTIATION

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

(2016) Noemí Arce-Varas et al.   Current Alzheimer Research

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

(2016) Eun Sun Jung et al.   Scientific Reports

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase

(2015) Amir Kumar Singh et al.   AGING CELL

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism

(2015) Mi Li et al.   NEUROBIOLOGY OF AGING

Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats

(2015) Natalia A. Stefanova et al.   Oncotarget

p53 and mitochondrial function in neurons

(2014) David B. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease

(2014) Aderbal R. T. Silva et al.   PLoS One

Pharmacological targeting of the β-amyloid precursor protein intracellular domain

(2014) Caterina Branca et al.   Scientific Reports

P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion

(2013) Mariana Pehar et al.   AGING CELL

Zyxin is a novel target for beta-amyloid peptide: characterization of its role in Alzheimer's pathogenesis

(2013) Cristina Lanni et al.   JOURNAL OF NEUROCHEMISTRY

Differential S-nitrosylation of proteins in Alzheimer’s disease

(2013) S. Zahid et al.   NEUROSCIENCE

Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease

(2013) Pavel Katsel et al.   PLoS One

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression

(2013) L Buizza et al.   Cell Death & Disease

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

(2013) Sharon C Yates et al.   Acta Neuropathologica Communications

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment

(2012) Serena Stanga et al.   Current Alzheimer Research

p53 at the crossroads between cancer and neurodegeneration

(2012) Cristina Lanni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease

(2012) Laura Buizza et al.   PLoS One

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death

(2010) Mariana Pehar et al.   AGING CELL

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased CD44 Gene Expression in Lymphocytes Derived from Alzheimer Disease Patients

(2010) D. Uberti et al.   Neurodegenerative Diseases

Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival

(2010) Cristina Lanni et al.   PLoS One

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

P53-mediated G1/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients

(2009) Xiaoying Zhou et al.   NEUROSCIENCE LETTERS

A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth and regeneration

(2008) A Tedeschi et al.   CELL DEATH AND DIFFERENTIATION

Pharmacogenetics and Pharmagenomics, Trends in Normal and Pathological Aging Studies: Focus on p53

(2008) C. Lanni et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

(2008) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

(2008) P. Sompol et al.   NEUROSCIENCE