Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long‐term graft‐localized immune privilege

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

Localized immune tolerance from FasL-functionalized PLG scaffolds

(2018) Michael Skoumal et al.   BIOMATERIALS

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance

(2014) Jason Miska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Either Split Tolerance or Robust Tolerance along with Humoral Tolerance to Donor and Third-Party Alloantigens in Nonmyeloablative Mixed Chimeras

(2014) W. F. N. Chan et al.   JOURNAL OF IMMUNOLOGY

Induction of Tolerance to Cardiac Allografts Using Donor Splenocytes Engineered to Display on Their Surface an Exogenous Fas Ligand Protein

(2014) E. S. Yolcu et al.   JOURNAL OF IMMUNOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Primary Vascularization of Allografts Governs Their Immunogenicity and Susceptibility to Tolerogenesis

(2013) C. D. Kant et al.   JOURNAL OF IMMUNOLOGY

Intragraft CD11b+IDO+Cells Mediate Cardiac Allograft Tolerance by ECDI-Fixed Donor Splenocyte Infusions

(2012) G. Chen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice

(2011) E. S. Yolcu et al.   JOURNAL OF IMMUNOLOGY

Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy

(2010) R K Sharma et al.   CANCER GENE THERAPY

In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response

(2010) Zhigang Fan et al.   NATURE MEDICINE

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

(2009) Lorraine A. O’ Reilly et al.   NATURE

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

(2008) Sylvain Perruche et al.   NATURE MEDICINE

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA