Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Ring-Opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles Using Lewis Acid

(2018) Subhankar Panda et al.   ACS Combinatorial Science

Arylation Chemistry for Bioconjugation

(2018) Bradley Pentelute et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion

(2018) Sihyeong Yi et al.   Frontiers in Chemistry

Organocatalytic asymmetric arylation of indoles enabled by azo groups

(2017) Liang-Wen Qi et al.   Nature Chemistry

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Insights on the immunogenicity of antibody–drug conjugates

(2015) Montserrat Carrasco-Triguero   Bioanalysis

Metal-Free Multicomponent Syntheses of Pyridines

(2014) Christophe Allais et al.   CHEMICAL REVIEWS

Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

(2014) Jonghoon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug–Drug Conjugate for Cancer Therapy

(2014) Ping Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research

(2013) Pau Celada et al.   CNS DRUGS

Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines

(2012) Christophe Allais et al.   ADVANCED SYNTHESIS & CATALYSIS

Identification of Oct4-activating compounds that enhance reprogramming efficiency

(2012) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition

(2012) Giammarco Tenti et al.   ACS Combinatorial Science

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

(2011) Sangmi Oh et al.   CHEMICAL COMMUNICATIONS

C–H Arylation of Pyridines: High Regioselectivity as a Consequence of the Electronic Character of C–H Bonds and Heteroarene Ring

(2011) Pengfei Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives

(2010) Masayuki Wasa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkyne activation with Brønsted acids, iodine, or gold complexes, and its fate leading to synthetic application

(2009) Yoshinori Yamamoto et al.   CHEMICAL COMMUNICATIONS

Use of β,γ-Unsaturated α-Ketocarbonyls for a Totally Regioselective Oxidative Multicomponent Synthesis of Polyfunctionalized Pyridines

(2009) Christophe Allais et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Efficient One-Step Synthesis of Heterobiaryl Pyrazolo[3,4-b]pyridines via Indole Ring Opening

(2009) Sanghee Lee et al.   ORGANIC LETTERS

Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

(2008) Frédéric Liéby-Muller et al.   CHEMICAL COMMUNICATIONS

Diversity-Oriented Synthesis of Privileged Benzopyranyl Heterocycles froms-cis-Enones

(2008) Heeseon An et al.   JOURNAL OF ORGANIC CHEMISTRY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nicotinic Acid: Pharmacological Effects and Mechanisms of Action

(2007) Andreas Gille et al.   Annual Review of Pharmacology and Toxicology