Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
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Title
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
Authors
Keywords
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Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-11
DOI
10.1038/s41467-020-20487-4
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Note: Only part of the references are listed.- Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
- (2019) Yong-Jie Zhang et al. SCIENCE
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- (2019) Mahmoud Khamis Aly et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2018) Tomohiro Yamazaki et al. MOLECULAR CELL
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- (2018) Hiroyuki Ishiura et al. NATURE GENETICS
- rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences
- (2018) Chantal Sellier et al. Nature Communications
- Multiple Modes of Protein–Protein Interactions Promote RNP Granule Assembly
- (2018) Tanja Mittag et al. JOURNAL OF MOLECULAR BIOLOGY
- The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity
- (2018) Fionna E. Loughlin et al. MOLECULAR CELL
- RNA phase transitions in repeat expansion disorders
- (2017) Ankur Jain et al. NATURE
- Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
- (2017) Taro Ishiguro et al. NEURON
- Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions
- (2017) Adam Ciesiolka et al. Frontiers in Cellular Neuroscience
- Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome
- (2016) Wang-Yong Yang et al. ACS Chemical Biology
- Synthesis of 1H-pyrrolo[3,2-h]quinoline-8-amine derivatives that target CTG trinucleotide repeats
- (2016) Jun Matsumoto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Naphthyridine-Benzoazaquinolone: Evaluation of a Tricyclic System for the Binding to (CAG)nRepeat DNA and RNA
- (2016) Jinxing Li et al. Chemistry-An Asian Journal
- Precise small-molecule recognition of a toxic CUG RNA repeat expansion
- (2016) Suzanne G Rzuczek et al. Nature Chemical Biology
- Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10
- (2016) Wang-Yong Yang et al. Nature Communications
- Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29 a
- (2015) Takeo Fukuzumi et al. CHEMISTRY-A EUROPEAN JOURNAL
- Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles
- (2015) Sven Hennig et al. JOURNAL OF CELL BIOLOGY
- Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA
- (2015) Wang-Yong Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Rationally Designed Small Molecules That Target Both the DNA and RNA Causing Myotonic Dystrophy Type 1
- (2015) Lien Nguyen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Selective small-molecule inhibition of an RNA structural element
- (2015) John A. Howe et al. NATURE
- SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
- (2015) James Palacino et al. Nature Chemical Biology
- A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor
- (2014) Suzanne G. Rzuczek et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
- (2014) Sunghee Cho et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Small Molecules that Target the Toxic RNA in Myotonic Dystrophy Type 2
- (2014) Lien Nguyen et al. ChemMedChem
- Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays
- (2014) Joanna Sztuba-Solinska et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS
- (2014) Zhaoming Su et al. NEURON
- A compendium of RNA-binding motifs for decoding gene regulation
- (2013) Debashish Ray et al. NATURE
- Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)nin the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis
- (2013) Yusuke Niimi et al. NEUROPATHOLOGY
- The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
- (2013) K. Mori et al. SCIENCE
- A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats
- (2012) Masaki Hagihara et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
- (2012) Elisa Majounie et al. LANCET NEUROLOGY
- Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes SCA36, a Type of Spinocerebellar Ataxia Accompanied by Motor Neuron Involvement
- (2011) Hatasu Kobayashi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor
- (2011) Kensuke Ninomiya et al. JOURNAL OF CELL BIOLOGY
- Pentanucleotide repeats at the spinocerebellar ataxia type 31 (SCA31) locus in Caucasians
- (2011) K. Ishikawa et al. NEUROLOGY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A modified fluorescent intercalator displacement assay for RNA ligand discovery
- (2010) Papa Nii Asare-Okai et al. ANALYTICAL BIOCHEMISTRY
- Fluorescent Indicator Displacement Assay for Ligand−RNA Interactions
- (2010) Jinhua Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Non-ATG-initiated translation directed by microsatellite expansions
- (2010) T. Zu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spinocerebellar Ataxia Type 31 Is Associated with “Inserted” Penta-Nucleotide Repeats Containing (TGGAA)n
- (2009) Nozomu Sato et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Recognition of Mismatched Base Pairs in DNA
- (2009) Kazuhiko Nakatani BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- Pentamidine reverses the splicing defects associated with myotonic dystrophy
- (2009) M. B. Warf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay
- (2008) Malathy Krishnamurthy et al. BIOORGANIC & MEDICINAL CHEMISTRY
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