Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Klebsiella michiganensis transmission enhances resistance to Enterobacteriaceae gut invasion by nutrition competition

(2020) Rita A. Oliveira et al.   Nature Microbiology

Identification of Clostridioides difficile-Inhibiting Gut Commensals Using Culturomics, Phenotyping, and Combinatorial Community Assembly

(2020) Sudeep Ghimire et al.   mSystems

An Enteric Pathogen Subverts Colonization Resistance by Evading Competition for Amino Acids in the Gut

(2020) Gustavo Caballero-Flores et al.   Cell Host & Microbe

Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization

(2020) Fátima C. Pereira et al.   Nature Communications

Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

(2019) Mahmoud M. Saleh et al.   Cell Host & Microbe

Probing Clostridium difficile Infection in Complex Human Gut Cellular Models

(2019) Blessing O. Anonye et al.   Frontiers in Microbiology

Cholera toxin promotes pathogen acquisition of host-derived nutrients

(2019) Fabian Rivera-Chávez et al.   NATURE

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Dietary l-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut

(2019) Sho Kitamoto et al.   Nature Microbiology

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

(2018) Caroline C. Gillis et al.   Cell Host & Microbe

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

(2018) L Clifford McDonald et al.   CLINICAL INFECTIOUS DISEASES

Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes

(2018) Fenfen Zhou et al.   INFLAMMATORY BOWEL DISEASES

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

(2018) Joshua R. Fletcher et al.   mSphere

Clostridium difficile Alters the Structure and Metabolism of Distinct Cecal Microbiomes during Initial Infection To Promote Sustained Colonization

(2018) Matthew L. Jenior et al.   mSphere

Multiple factors contribute to bimodal toxin gene expression in Clostridioides (Clostridium) difficile

(2018) Eric M. Ransom et al.   MOLECULAR MICROBIOLOGY

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria

(2018) Ian J. Passmore et al.   PLoS Pathogens

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

(2018) Julia D. Hofmann et al.   Frontiers in Microbiology

Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation

(2018) Huimin Deng et al.   Frontiers in Microbiology

High metabolic versatility of different toxigenic and non-toxigenic Clostridioides difficile isolates

(2017) Thomas Riedel et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A prominent glycyl radical enzyme in human gut microbiomes metabolizestrans-4-hydroxy-l-proline

(2017) B. J. Levin et al.   SCIENCE

A genetic switch controls the production of flagella and toxins in Clostridium difficile

(2017) Brandon R. Anjuwon-Foster et al.   PLoS Genetics

Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291

(2017) Brintha P. Girinathan et al.   mSphere

Clostridium difficile Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut Microbiomes

(2017) Matthew L. Jenior et al.   mSystems

The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases

(2016) Magali de Bruyn et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

(2016) Jenessa A. Winston et al.   Jove-Journal of Visualized Experiments

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

(2016) Carrie A. Cowardin et al.   Nature Microbiology

Time-resolved amino acid uptake of Clostridium difficile 630Δerm and concomitant fermentation product and toxin formation

(2015) Meina Neumann-Schaal et al.   BMC MICROBIOLOGY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

(2014) Jessica A. Ferreyra et al.   Cell Host & Microbe

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species

(2013) E. Goldberg et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The Clostridium difficile cpr Locus Is Regulated by a Noncontiguous Two-Component System in Response to Type A and B Lantibiotics

(2013) J. M. Suarez et al.   JOURNAL OF BACTERIOLOGY

The SILVA and “All-species Living Tree Project (LTP)” taxonomic frameworks

(2013) Pelin Yilmaz et al.   NUCLEIC ACIDS RESEARCH

Expanding the Repertoire of Gene Tools for Precise Manipulation of the Clostridium difficile Genome: Allelic Exchange Using pyrE Alleles

(2013) Yen Kuan Ng et al.   PLoS One

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

(2013) Paul J. McMurdie et al.   PLoS One

Impact ofClostridium difficilecolitis on 5-year health outcomes in patients with ulcerative colitis

(2012) S. K. Murthy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

Prolidase function in proline metabolism and its medical and biotechnological applications

(2012) R.L. Kitchener et al.   JOURNAL OF APPLIED MICROBIOLOGY

Proline-Dependent Regulation of Clostridium difficile Stickland Metabolism

(2012) L. Bouillaut et al.   JOURNAL OF BACTERIOLOGY

Increased health burden associated with Clostridium difficile diarrhoea in patients with inflammatory bowel disease

(2011) M-H. Jen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains

(2011) Lisa F Dawson et al.   BMC MICROBIOLOGY

Identification of a Genetic Locus Responsible for Antimicrobial Peptide Resistance inClostridium difficile

(2010) Shonna M. McBride et al.   INFECTION AND IMMUNITY

Regulation of CodY Activity through Modulation of Intracellular Branched-Chain Amino Acid Pools

(2010) S. R. Brinsmade et al.   JOURNAL OF BACTERIOLOGY

Integration of Metabolism and Virulence by Clostridium difficile CodY

(2010) S. S. Dineen et al.   JOURNAL OF BACTERIOLOGY

Gut inflammation provides a respiratory electron acceptor for Salmonella

(2010) Sebastian E. Winter et al.   NATURE

Evolutionary dynamics of Clostridium difficile over short and long time scales

(2010) M. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

(2008) Eric C. Martens et al.   Cell Host & Microbe

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY