Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins

(2020) Shitao Zou et al.   JOURNAL OF VIROLOGY

HIV-1 protease, Gag and gp41 baseline substitutions associated with virological response to a PI-based regimen

(2019) Marine Perrier et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New mechanisms of resistance in virological failure to protease inhibitors: selection of non-described protease, Gag and Gp41 mutations

(2019) Louise Castain et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function

(2019) Hanh T. Nguyen et al.   JOURNAL OF VIROLOGY

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

(2019) Maolin Lu et al.   NATURE

Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle

(2019) Rachel Van Duyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation

(2019) Qian Wang et al.   Cell Reports

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

(2019) D.A. Collier et al.   Cell Host & Microbe

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition

(2019) Alan N. Engelman   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

(2019) Sean C. Patro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

(2019) Mark S Ladinsky et al.   eLife

Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell–cell viral transmission and cell–cell fusion

(2018) Vani G. S. Narasimhulu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy

(2018) Ingeborg E A Wijting et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120

(2018) Paul W. Keller et al.   JOURNAL OF VIROLOGY

SOSIP changes affect human immunodeficiency virus (HIV-1) envelope glycoprotein conformation and CD4 engagement

(2018) Nirmin Alsahafi et al.   JOURNAL OF VIROLOGY

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

(2018) Terumasa Ikeda et al.   PLoS Pathogens

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

(2018) Xiaochu Ma et al.   eLife

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies

(2018) Jérémy Dufloo et al.   Retrovirology

Dolutegravir monotherapy versus dolutegravir/abacavir/lamivudine for virologically suppressed people living with chronic HIV infection: the randomized non-inferiority MONCAY trial

(2018) Laurent Hocqueloux et al.   CLINICAL INFECTIOUS DISEASES

Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes

(2018) Koen K. A. Van Rompay et al.   JOURNAL OF VIROLOGY

RESISTANCE TO SECOND-GENERATION HIV-1 MATURATION INHIBITORS

(2018) Emiko Urano et al.   JOURNAL OF VIROLOGY

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

(2017) Marie Pancera et al.   Nature Chemical Biology

Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

(2017) Ann Wiegand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV drug resistance against strand transfer integrase inhibitors

(2017) Kaitlin Anstett et al.   Retrovirology

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

(2017) Isabelle Malet et al.   mBio

Gp41 and Gag amino acids linked to HIV-1 protease inhibitor-based second-line failure in HIV-1 subtype A from Western Kenya

(2017) Mia Coetzer et al.   Journal of the International AIDS Society

They Might Be Giants: Does Syncytium Formation Sink or Spread HIV Infection?

(2017) Alex A. Compton et al.   PLoS Pathogens

Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography

(2017) Collin Kieffer et al.   eLife

Evolution of gag and gp41 in Patients Receiving Ritonavir-Boosted Protease Inhibitors

(2017) Justen Manasa et al.   Scientific Reports

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

(2016) Guillaume B.E. Stewart-Jones et al.   CELL

Random lopinavir concentrations predict resistance on lopinavir-based antiretroviral therapy

(2016) Richard Court et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Increased HIV-1 sensitivity to neutralizing antibodies by mutations in the Env V3-coding region for resistance to CXCR4 antagonists

(2016) Yuta Hikichi et al.   JOURNAL OF GENERAL VIROLOGY

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

(2016) Beatriz Pacheco et al.   JOURNAL OF VIROLOGY

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

(2016) Alon Herschhorn et al.   mBio

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell

(2016) Mikaël Boullé et al.   PLoS Pathogens

Raltegravir in second-line antiretroviral therapy in resource-limited settings (SELECT): a randomised, phase 3, non-inferiority study

(2016) Alberto M La Rosa et al.   Lancet HIV

HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts

(2015) Menelaos Symeonides et al.   Viruses-Basel

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

(2015) Jingyou Yu et al.   Cell Reports

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

(2015) Lucia Reh et al.   PLoS Pathogens

Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimer

(2015) Nirmin Alsahafi et al.   PLoS One

Impact of maraviroc-resistant and low-CCR5-adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies

(2014) K. Yoshimura et al.   JOURNAL OF GENERAL VIROLOGY

Ezrin Is a Component of the HIV-1 Virological Presynapse and Contributes to the Inhibition of Cell-Cell Fusion

(2014) N. H. Roy et al.   JOURNAL OF VIROLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

Fitness Impaired Drug Resistant HIV-1 Is Not Compromised in Cell-to-Cell Transmission or Establishment of and Reactivation from Latency

(2014) Sophie Bastarache et al.   Viruses-Basel

Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue

(2014) Mark S. Ladinsky et al.   PLoS Pathogens

Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission

(2014) Luis M. Agosto et al.   PLoS Pathogens

Significant Differences in Cell–Cell Fusion and Viral Entry between Strains Revealed by Scanning Mutagenesis of the C-Heptad Repeat of HIV gp41

(2013) Barbara Diaz-Aguilar et al.   BIOCHEMISTRY

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

(2013) George L. Melikian et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance

(2013) S. Alireza Rabi et al.   JOURNAL OF CLINICAL INVESTIGATION

Emergence of HIV Drug Resistance During First- and Second-Line Antiretroviral Therapy in Resource-Limited Settings

(2013) Mina C. Hosseinipour et al.   JOURNAL OF INFECTIOUS DISEASES

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cell-to-Cell Transmission Can Overcome Multiple Donor and Target Cell Barriers Imposed on Cell-Free HIV

(2013) Peng Zhong et al.   PLoS One

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells

(2013) Boghuma Titanji et al.   Retrovirology

Multiple proviral integration events after virological synapse-mediated HIV-1 spread

(2013) Rebecca A. Russell et al.   VIROLOGY

HIV: Cell Binding and Entry

(2013) C. B. Wilen et al.   Cold Spring Harbor Perspectives in Medicine

Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes

(2013) Constantinos Kurt Wibmer et al.   PLoS Pathogens

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

(2013) Heidi E. Drummer et al.   PLoS Pathogens

Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4+ T-cells Contain One HIV-1 DNA Molecule

(2013) Lina Josefsson et al.   PLoS Pathogens

No Evidence for Evolution of Protease Inhibitor Resistance from Standard Genotyping, After Three Years of Treatment with Darunavir/Ritonavir, With or Without Nucleoside Analogues

(2012) Federico Pulido et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Neutralization Resistance of Virological Synapse-Mediated HIV-1 Infection Is Regulated by the gp41 Cytoplasmic Tail

(2012) N. D. Durham et al.   JOURNAL OF VIROLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Quantification of Unintegrated HIV-1 DNA at the Single Cell Level In Vivo

(2012) Rodolphe Suspène et al.   PLoS One

Structural Plasticity and Conformational Transitions of HIV Envelope Glycoprotein gp120

(2012) Anil Korkut et al.   PLoS One

Human Immunodeficiency Virus gag and protease: partners in resistance

(2012) Axel Fun et al.   Retrovirology

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

Low Lopinavir Plasma or Hair Concentrations Explain Second-Line Protease Inhibitor Failures in a Resource-Limited Setting

(2011) Gert Uves van Zyl et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

(2011) Mary Ann Checkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection

(2011) A. Del Portillo et al.   JOURNAL OF VIROLOGY

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition

(2010) N. Martin et al.   JOURNAL OF VIROLOGY

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

(2010) Andrés Finzi et al.   MOLECULAR CELL

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

T Cell Polarization at the Virological Synapse

(2010) Clare Jolly   Viruses-Basel

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase

(2009) Mary Kearney et al.   AIDS

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

(2009) Jesus F. Salazar-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses

(2009) D. Rudnicka et al.   JOURNAL OF VIROLOGY

Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses

(2009) W. Hubner et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Functional role of Alix in HIV-1 replication

(2009) Ken Fujii et al.   VIROLOGY

Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins

(2009) Feng Gao et al.   VIROLOGY

Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

(2009) Kristen M. Kahle et al.   PLoS Pathogens

Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

(2009) Reem Berro et al.   PLoS Pathogens

Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing

(2008) J. F. Salazar-Gonzalez et al.   JOURNAL OF VIROLOGY

Real-Time Visualization of HIV-1 GAG Trafficking in Infected Macrophages

(2008) Karine Gousset et al.   PLoS Pathogens