The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers

FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13

(2020) Shenxiang Liu et al.   EXPERIMENTAL CELL RESEARCH

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

(2020) Kulsoom Zahra et al.   Frontiers in Oncology

Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors

(2020) Peng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia

(2020) Teresa D'Altri et al.   HAEMATOLOGICA

Down-regulation of FTO promotes proliferation and migration, and protects bladder cancer cells from cisplatin-induced cytotoxicity

(2020) Lijie Wen et al.   BMC Urology

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

(2020) Rui Su et al.   CANCER CELL

FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling

(2020) Hao Huang et al.   CANCER RESEARCH

USP7 manipulation by viral proteins

(2020) Anna Bojagora et al.   VIRUS RESEARCH

N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis

(2019) Changshui Zhuang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Golgi Membrane Protein 1 (GOLM1) Promotes Growth and Metastasis of Breast Cancer Cells via Regulating Matrix Metalloproteinase-13 (MMP13)

(2019) Rui Zhang et al.   MEDICAL SCIENCE MONITOR

The role of m6A RNA methylation in cancer

(2019) Ting Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells

(2019) Inge Van Der Werf et al.   CANCER CELL

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

The relation between PI3K/AKT signalling pathway and cancer

(2019) Saeed Noorolyai et al.   GENE

Hypoxia-Inducible Factor-1α (HIF-1α) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13)

(2019) Hui Zhang et al.   MEDICAL SCIENCE MONITOR

The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells

(2019) Dongling Zou et al.   Cancer Cell International

m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

(2018) Jiqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

Exercise increases mitochondrial PGC-1 α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

(2018) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7: Target Validation and Drug Discovery for Cancer Therapy

(2018) Jin Zhou et al.   Medicinal Chemistry

Critical Enzymatic Functions of FTO in Obesity and Cancer

(2018) Xiaolan Deng et al.   Frontiers in Endocrinology

FTO mRNA expression in the lower quartile is associated with bad prognosis in clear cell renal cell carcinoma based on TCGA data mining

(2018) Lijie Wen et al.   Annals of Diagnostic Pathology

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

FTO Gene Affects Obesity and Breast Cancer Through Similar Mechanisms: A New Insight into the Molecular Therapeutic Targets

(2017) M. E. Akbari et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

FTO expression is associated with the occurrence of gastric cancer and prognosis

(2017) Dong Xu et al.   ONCOLOGY REPORTS

The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway

(2017) Yazhuo Liu et al.   Oncology Letters

Is FTO gene variant related to cancer risk independently of adiposity? An updated meta-analysis of 129,467 cases and 290,633 controls

(2017) Yu Kang et al.   Oncotarget

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

(2016) Baiyu Yang et al.   Cancer Epidemiology

Selected single-nucleotide polymorphisms inFOXE1,SERPINA5,FTO,EVPL,TICAM1andSCARB1are associated with papillary and follicular thyroid cancer risk: replication study in a German population

(2016) Alice J. Sigurdson et al.   CARCINOGENESIS

Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway

(2016) YAPING ZHU et al.   ONCOLOGY REPORTS

Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic Challenge

(2016) Balraj Singh et al.   PLoS One

Association of FTO Mutations with Risk and Survival of Breast Cancer in a Chinese Population

(2015) Xianxu Zeng et al.   DISEASE MARKERS

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview

(2014) Marta Elena Hernández-Caballero et al.   MOLECULAR BIOLOGY REPORTS

The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss

(2014) L-H Tsai et al.   ONCOGENE

Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

(2014) K Sakamoto et al.   Blood Cancer Journal

Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case–control study in Japan

(2013) Yingsong Lin et al.   BMC CANCER

Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk

(2013) Patrícia Amorim da Cunha et al.   MOLECULAR BIOLOGY REPORTS

Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways

(2012) Zhenbo Zhang et al.   CANCER LETTERS

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls

(2012) Guiqiong Li et al.   TUMOR BIOLOGY

ECSASB2 mediates MLL degradation during hematopoietic differentiation

(2011) J. Wang et al.   BLOOD

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk

(2011) Virginia Kaklamani et al.   BMC Medical Genetics

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signalling

(2011) Aleck W.E. Jones et al.   MITOCHONDRION

Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk

(2011) Renata Kusinska et al.   MOLECULAR BIOLOGY REPORTS

The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women

(2011) Galina Lurie et al.   PLoS One

No Association between FTO or HHEX and Endometrial Cancer Risk

(2010) M. M. Gaudet et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Associations between an Obesity Related Genetic Variant (FTO rs9939609) and Prostate Cancer Risk

(2010) Sarah J. Lewis et al.   PLoS One

Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

(2009) P. Brennan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY