Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

(2020) Yutaka Hashimoto et al.   Nature Communications

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

(2020) Pítia Flores Ledur et al.   Scientific Reports

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

(2020) Franck Touret et al.   Scientific Reports

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

(2020) Eric J. Snijder et al.   PLOS BIOLOGY

Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR

(2020) Ioanna Smyrlaki et al.   Nature Communications

The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019

(2019) Oly Ilunga Kalenga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B

(2019) Kelly L. Warfield et al.   Scientific Reports

Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib

(2018) Teemu P Miettinen et al.   EMBO JOURNAL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

(2018) Torkild Visnes et al.   SCIENCE

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

(2016) Matthew K. Howe et al.   ANTIVIRAL RESEARCH

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle

(2016) Rebecca Surtees et al.   JOURNAL OF VIROLOGY

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

(2016) Isabelle Becher et al.   Nature Chemical Biology

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

(2015) Friedrich B M Reinhard et al.   NATURE METHODS

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

(2015) Holger Franken et al.   Nature Protocols

Oxidative stress influences positive strand RNA virus genome synthesis and capping

(2015) Rebekah C. Gullberg et al.   VIROLOGY

HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

(2015) Alexander Ivanov et al.   Viruses-Basel

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

(2014) X. Deng et al.   JOURNAL OF VIROLOGY

Case fatality rate for Ebola virus disease in west Africa

(2014) Adam J Kucharski et al.   LANCET

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone

(2014) John S. Schieffelin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

(2014) Lisa Oestereich et al.   PLoS Neglected Tropical Diseases

HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics

(2013) Rui M M Branca et al.   NATURE METHODS

Pathogenesis of Crimean-Congo Hemorrhagic Fever

(2013) Esragül Akıncı et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility

(2013) Rong Hai et al.   Nature Communications

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Enterovirus-Induced miR-141 Contributes to Shutoff of Host Protein Translation by Targeting the Translation Initiation Factor eIF4E

(2011) Bing-Ching Ho et al.   Cell Host & Microbe

Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean-Congo hemorrhagic fever virus

(2011) S. D. Dowall et al.   JOURNAL OF GENERAL VIROLOGY

The dependence of viral RNA replication on co-opted host factors

(2011) Peter D. Nagy et al.   NATURE REVIEWS MICROBIOLOGY

Quantitative analysis of particles, genomes and infectious particles in supernatants of haemorrhagic fever virus cell cultures

(2011) Manfred Weidmann et al.   Virology Journal

BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection

(2011) E. C. Goodwin et al.   mBio

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens