Why and How to Dig into Plant Metabolite–Protein Interactions

A genome-wide approach for identification and characterisation of metabolite-inducible systems

(2020) Erik K. R. Hanko et al.   Nature Communications

Mass-spectrometry-based draft of the Arabidopsis proteome

(2020) Julia Mergner et al.   NATURE

Diverse allyl glucosinolate catabolites independently influence root growth and development

(2020) Ella Katz et al.   PLANT PHYSIOLOGY

Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences

(2020) Elia Lacchini et al.   Annual Review of Cell and Developmental Biology

Towards a functional understanding of the plant metabolome

(2020) Monika Kosmacz et al.   CURRENT OPINION IN PLANT BIOLOGY

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

(2020) Michael P. O’Donnell et al.   NATURE

Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy

(2020) Matthias Erb et al.   PLANT PHYSIOLOGY

Extracellular ATP shapes a defense-related transcriptome both independently and along with other defense signaling pathways

(2019) Jeremy B. Jewell et al.   PLANT PHYSIOLOGY

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

(2019) Jerzy M. Dziekan et al.   Science Translational Medicine

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

(2019) Sindhuja Sridharan et al.   Nature Communications

The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

(2019) Jian You Wang et al.   Nature Communications

Optimized small‐molecule pull‐downs define MLBP 1 as an acyl‐lipid‐binding protein

(2019) Yelena Sterlin et al.   PLANT JOURNAL

A gossypol biosynthetic intermediate disturbs plant defence response

(2019) Xiu Tian et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Emerging strategies for the identification of protein-metabolite interactions

(2019) Marcin Luzarowski et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Age of Coumarins in Plant–Microbe Interactions

(2019) Ioannis A Stringlis et al.   PLANT AND CELL PHYSIOLOGY

The MYB transcription factor emission of methyl anthranilate 1 stimulates emission of methyl anthranilate from Medicago truncatula hairy roots

(2019) Jacob Pollier et al.   PLANT JOURNAL

β-Cyclocitral is a conserved root growth regulator

(2019) Alexandra J. Dickinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A specialized metabolic network selectively modulates Arabidopsis root microbiota

(2019) Ancheng C. Huang et al.   SCIENCE

Systematic mapping of protein‐metabolite interactions in central metabolism of Escherichia coli

(2019) Maren Diether et al.   Molecular Systems Biology

Glucosinolate and phenylpropanoid biosynthesis are linked by proteasome‐dependent degradation of PAL

(2019) Jeong Im Kim et al.   NEW PHYTOLOGIST

Rhizosphere-Associated Pseudomonas Suppress Local Root Immune Responses by Gluconic Acid-Mediated Lowering of Environmental pH

(2019) Ke Yu et al.   CURRENT BIOLOGY

Custom-made transcriptional biosensors for metabolic engineering

(2019) Mathilde Koch et al.   CURRENT OPINION IN BIOTECHNOLOGY

A metagenomic strategy for harnessing the chemical repertoire of the human microbiome

(2019) Yuki Sugimoto et al.   SCIENCE

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels

(2019) Mohammad Salehin et al.   Nature Communications

Anchorene is a carotenoid-derived regulatory metabolite required for anchor root formation in Arabidopsis

(2019) Kun-Peng Jia et al.   Science Advances

Methyl anthranilate: A novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria

(2019) Tingting Li et al.   FOOD MICROBIOLOGY

Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques

(2019) Shanshan Li et al.   CURRENT OPINION IN BIOTECHNOLOGY

Transcription factor-based biosensors and inducible systems in non-model bacteria: current progress and future directions

(2019) Nancy M Kim et al.   CURRENT OPINION IN BIOTECHNOLOGY

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

(2018) Ilaria Piazza et al.   CELL

PROMIS, global analysis of PROtein-Metabolite Interactions using Size separation inArabidopsis thaliana

(2018) Daniel Veyel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYB72-dependent coumarin exudation shapes root microbiome assembly to promote plant health

(2018) Ioannis A. Stringlis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

(2018) Fabian Panter et al.   Chemical Science

Root exudate metabolites drive plant-soil feedbacks on growth and defense by shaping the rhizosphere microbiota

(2018) Lingfei Hu et al.   Nature Communications

Protein Extraction Methods Shape Much of the Extracted Proteomes

(2018) Liangjie Niu et al.   Frontiers in Plant Science

Plant iron acquisition strategy exploited by an insect herbivore

(2018) L. Hu et al.   SCIENCE

Glutamate triggers long-distance, calcium-based plant defense signaling

(2018) Masatsugu Toyota et al.   SCIENCE

A gut microbial factor modulates locomotor behaviour in Drosophila

(2018) Catherine E. Schretter et al.   NATURE

The Peroxidative Cleavage of Kaempferol Contributes to the Biosynthesis of the Benzenoid Moiety of Ubiquinone in Plants

(2018) Eric Soubeyrand et al.   PLANT CELL

The decoration of specialized metabolites influences stylar development

(2018) Jiancai Li et al.   eLife

Affinity purification with metabolomic and proteomic analysis unravels diverse roles of nucleoside diphosphate kinases

(2017) Marcin Luzarowski et al.   JOURNAL OF EXPERIMENTAL BOTANY

Coumarin enhances nitrate uptake in maize roots through modulation of plasma membrane H+ -ATPase activity

(2017) A. Lupini et al.   PLANT BIOLOGY

Extracellular ATP Acts on Jasmonate Signaling to Reinforce Plant Defense

(2017) Diwaker Tripathi et al.   PLANT PHYSIOLOGY

Genome-Wide Prediction of Metabolic Enzymes, Pathways, and Gene Clusters in Plants

(2017) Pascal Schläpfer et al.   PLANT PHYSIOLOGY

Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture

(2017) Dongqin Chen et al.   Nature Communications

An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway

(2017) Frederikke Gro Malinovsky et al.   eLife

Systematic Identification of Protein–Metabolite Interactions in Complex Metabolite Mixtures by Ligand-Detected Nuclear Magnetic Resonance Spectroscopy

(2016) Yaroslav V. Nikolaev et al.   BIOCHEMISTRY

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Sensing new chemicals with bacterial transcription factors

(2016) Vincent Libis et al.   CURRENT OPINION IN MICROBIOLOGY

cis-Cinnamic Acid Is a Novel, Natural Auxin Efflux Inhibitor That Promotes Lateral Root Formation

(2016) Ward Steenackers et al.   PLANT PHYSIOLOGY

Omic Relief for the Biotically Stressed: Metabolomics of Plant Biotic Interactions

(2016) Hezi Tenenboim et al.   TRENDS IN PLANT SCIENCE

The Defense Metabolite, Allyl Glucosinolate, Modulates Arabidopsis thaliana Biomass Dependent upon the Endogenous Glucosinolate Pathway

(2016) Marta Francisco et al.   Frontiers in Plant Science

Integrated metabolomics for abiotic stress responses in plants

(2015) Ryo Nakabayashi et al.   CURRENT OPINION IN PLANT BIOLOGY

Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects

(2015) Lloyd W. Sumner et al.   NATURAL PRODUCT REPORTS

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

(2015) Kilian V M Huber et al.   NATURE METHODS

Indole Glucosinolate Biosynthesis Limits Phenylpropanoid Accumulation inArabidopsis thaliana

(2015) Jeong Im Kim et al.   PLANT CELL

The glucosinolate breakdown product indole-3-carbinol acts as an auxin antagonist in roots ofArabidopsis thaliana

(2015) Ella Katz et al.   PLANT JOURNAL

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis

(2015) Chunhua Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural variation in cross-talk between glucosinolates and onset of flowering in Arabidopsis

(2015) Lea M. Jensen et al.   Frontiers in Plant Science

Advances in plant proteomics toward improvement of crop productivity and stress resistancex

(2015) Junjie Hu et al.   Frontiers in Plant Science

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Identification of a Plant Receptor for Extracellular ATP

(2014) J. Choi et al.   SCIENCE

Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis

(2013) Sang-Wook Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation

(2012) Erin C Strickland et al.   Nature Protocols

Regulatory switch enforced by basic helix-loop-helix and ACT-domain mediated dimerizations of the maize transcription factor R

(2012) Que Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

(2011) Christopher Chidley et al.   Nature Chemical Biology

GLYCOALKALOID METABOLISM1 Is Required for Steroidal Alkaloid Glycosylation and Prevention of Phytotoxicity in Tomato

(2011) M. Itkin et al.   PLANT CELL

Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses

(2010) Xiyan Li et al.   CELL

Macroevolution and the biological diversity of plants and herbivores

(2009) D. J. Futuyma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic Analysis of Protein Stability and Ligand Binding Using a Chemical Modification- and Mass Spectrometry-Based Strategy

(2008) Graham M. West et al.   ANALYTICAL CHEMISTRY

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY

Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants

(2008) S. Sirikantaramas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA