Article
Oncology
Martial Caillaud, Nipa H. Patel, Wisam Toma, Alyssa White, Danielle Thompson, Jared Mann, Tammy H. Tran, Jane L. Roberts, Justin L. Poklis, John W. Bigbee, Xianjun Fang, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrates the therapeutic potential of fenofibrate in preventing paclitaxel-induced peripheral neuropathy by reducing pain symptoms through modulation of PPAR-alpha expression and decreasing neuroinflammation. This suggests a possible repurposing of fenofibrate in the clinic for preventing paclitaxel-induced neuropathy.
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Michael Fetell, Manon Sendel, Thomas Li, Leslie Marinelli, Jan Vollert, Elizaeth Ruggerio, George Houk, Marilyn Dockum, Phillip J. Albrecht, Frank L. Rice, Ralf Baron
Summary: Skin biopsies from patients with postherpetic neuralgia (PHN) showed no correlation between nerve fiber density and baseline pain, and concurrent loss of nerve fibers on the affected side was common. The role of Nav1.7 in PHN pain is still unclear.
Article
Anesthesiology
Johan Roikjer, Suganthiya Santhiapillai Croosu, Jens Brondum Frokjaer, Tine Maria Hansen, Lars Arendt-Nielsen, Niels Ejskjaer, Carsten Dahl Morch
Summary: This study aimed to validate a new method for assessing small sensory nerve function in diabetes and further understand why some people with diabetes develop painful neuropathies. The researchers assessed large and small nerve function using a novel perception threshold tracking technique in different groups of individuals with type 1 diabetes. The study found that the nerve properties were specific in individuals with diabetes and pain, with significant differences between the groups.
Review
Immunology
Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Nathan T. Fiore, Zhuoran Yin, Dilansu Guneykaya, Christian D. Gauthier, Jessica Hayes, Aaron D'Hary, Oleg Butovsky, Gila Moalem-Taylor
Summary: Neuropathic pain is associated with the activation of glial cells, particularly microglia, in the central nervous system. This study found that microglia play a sexually dimorphic role in neuropathic pain in rodent models. Analysis of microglial gene expression revealed no common transcriptional changes in different neuropathic models, but a significant change was observed in the lumbar spinal cord after chronic constriction injury. Furthermore, male microglia from nerve-injured mice showed a unique transcriptional signature and increased phagocytotic activity. These findings suggest that spinal microglia contribute to sex-specific pain processing following nerve injury.
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Article
Biochemistry & Molecular Biology
Kensaku Itoh, Megumi Shimoyama, Peter W. Schiller, Satoshi Toyama
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of paclitaxel, a widely used chemotherapeutic drug. Dysfunction or injury of mitochondria has been suggested to be involved in the induction of this neuropathy. This study aimed to examine the protective effect of SS-20, a tetrapeptide that targets mitochondria, against paclitaxel-induced peripheral neuropathy using a murine model. The results suggest that SS-20 may be a potential drug candidate for the prevention of CIPN.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Neurosciences
Paola Pacifico, James S. Coy-Dibley, Richard J. Miller, Daniela M. Menichella
Summary: This article reviews new approaches for treating peripheral neuropathic pain, including disease modifying therapies and advanced techniques for uncovering novel mechanisms. It also highlights the potential of drug treatment applied topically and the role of non-neuronal cells and communication between the skin and sensory afferents. Lastly, it discusses the current challenges in developing new therapies and improving the translation of research findings from animal models to the clinic.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Franziska Karl-Schoeller, Meik Kunz, Luisa Kress, Melissa Held, Nadine Egenolf, Anna Wiesner, Thomas Dandekar, Claudia Sommer, Nurcan Ueceyler
Summary: Neuropathic pain is common in peripheral neuropathy patients, and the study investigated the role of miR-21 in this pain. Inhibition of miR-21-5p reversed mechanical and heat hypersensitivity in mice with nerve injury, leading to a decrease in pro-inflammatory mediators. The study also found different expression patterns of miR-21-5p and pro-inflammatory mediators in human patients with neuropathic pain syndromes.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Standiford Helm, Nikita Shirsat, Aaron Calodney, Alaa Abd-Elsayed, David Kloth, Amol Soin, Shalini Shah, Andrea Trescot
Summary: PNS shows level II evidence for treating refractory peripheral nerve injury and level III evidence for certain other pain conditions. The risk of adverse events with PNS is generally low compared to spinal cord stimulation. However, there is a lack of literature on certain indications for PNS treatment.
Review
Biochemistry & Molecular Biology
Vincent Yaccarino, Max Y. Jin, Alaa Abd-Elsayed, Jacob M. Kraemer, Nalini Sehgal
Summary: This article briefly introduces the evolution, mechanisms, applications, and complications of peripheral nerve stimulation. The latest technology provides new treatment options for chronic neuropathic pain of the upper extremity.
Article
Immunology
Wei Li, Jie Liang, Shaohua Li, Luoyang Wang, Shuo Xu, Suli Jiang, Meiying Song, Haining Meng, Dongchang Zhai, Lei Tang, Yanyan Yang, Li Zhang, Bei Zhang
Summary: This article summarizes the mechanisms of nerve damage and pain caused by excessive activation of the NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Anesthesiology
Chi-Chao Chao, Ming-Tsung Tseng, Yea-Huey Lin, Paul-Chen Hsieh, Chien-Ho (Janice) Lin, Shin-Leh Huang, Sung-Tsang Hsieh, Ming-Chang Chiang
Summary: Patients with SFN showed reduced white matter connectivity with pain-related brain areas, with the degree of skin nerve degeneration correlated with different neuropathic pain phenotypes. Despite altered connectivity, there was no change in white matter integrity as assessed by fractional anisotropy. Our findings suggest that changes in structural connectivity may serve as a biomarker of maladaptive brain plasticity contributing to neuropathic pain following peripheral nerve degeneration.
Review
Neurosciences
Roberto Velasco-Gonzalez, Ulises Coffeen
Summary: Chemotherapy is widely used for cancer treatment, but it can lead to chemotherapy-induced peripheral neuropathy (CIPN) with unclear mechanisms.
NEUROTOXICITY RESEARCH
(2022)
Article
Immunology
Martial Caillaud, Nipa H. Patel, Alyssa White, Mackinsey Wood, Katherine M. Contreras, Wisam Toma, Yasmin Alkhlaif, Jane L. Roberts, Tammy H. Tran, Asti B. Jackson, Justin Poklis, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrated the therapeutic potential of fibrates, specifically fenofibrate and choline fenofibrate, in reversing and preventing pain sensitivity in peripheral neuropathies associated with paclitaxel treatment. Additionally, these fibrates did not diminish the antitumoral effects of paclitaxel, suggesting a potential for their pharmacological repurposing in PIPN.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Martial Caillaud, Nipa H. Patel, Wisam Toma, Alyssa White, Danielle Thompson, Jared Mann, Tammy H. Tran, Jane L. Roberts, Justin L. Poklis, John W. Bigbee, Xianjun Fang, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrates the therapeutic potential of fenofibrate in preventing paclitaxel-induced peripheral neuropathy by reducing pain symptoms through modulation of PPAR-alpha expression and decreasing neuroinflammation. This suggests a possible repurposing of fenofibrate in the clinic for preventing paclitaxel-induced neuropathy.
Article
Behavioral Sciences
Katherine M. Contreras, Martial Caillaud, Bradley Neddenriep, Deniz Bagdas, Jane L. Roberts, Esad Ulker, Alyssa B. White, Raneem Aboulhosn, Wisam Toma, Tala Khalefa, Ahd Adel, Jared A. Mann, M. Imad Damaj
Summary: Treatment with CFA reduced the distance traveled in C57BL/6J mice but not in DBA/2J mice; paclitaxel induced CIPN in mice, with only female C57BL/6J mice showing a decrease in distance traveled following treatment;amp; CCI surgery resulted in a gradual decrease in mechanical sensitivity and distance traveled in mice. Comparing these chronic pain models in different mouse strains may help to understand the genetic differences underlying pain perception and its impact on behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Anesthesiology
Wisam Toma, Martial Caillaud, Nipa H. Patel, Tammy H. Tran, Giulia Donvito, Jane Roberts, Deniz Bagdas, Asti Jackson, Aron Lichtman, David A. Gewirtz, Alexandros Makriyannis, Michael S. Malamas, M. Imad Damaj
Summary: The study shows that paclitaxel reduces PEA levels in the spinal cord, while exogenous administration of PEA partially alleviates PIPN. Additionally, targeting NAAA enzyme with specific compound AM9053 can reverse and prevent PIPN. These findings suggest that selective NAAA inhibitors could be promising future therapeutics for the treatment and prevention of PIPN.
EUROPEAN JOURNAL OF PAIN
(2021)
Article
Dermatology
Neda Vishlaghi, Sandra Rieger, Vanessa McGaughey, Thomas S. Lisse
Summary: The authors propose that GDNF can promote hair follicle neogenesis and skin regeneration by directing the fate of dermal fibroblasts. They plan to conduct lineage-tracing experiments and RNA sequencing experiments to study the mechanism of GDNF. This research is of great significance for advancing the fields of regenerative medicine and biology.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Antonio Cadiz Diaz, Natalie A. Schmidt, Mamiko Yamazaki, Chia-Jung Hsieh, Thomas S. Lisse, Sandra Rieger
Summary: Tissue wounding induces axon regeneration through distinct mechanisms involving both neurons and keratinocytes, mediated by H2O2 signaling and matrix remodeling. These processes are essential for the regeneration of cutaneous axons after injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Martial Caillaud, Danielle Thompson, Wisam Toma, Alyssa White, Jared Mann, Jane L. Roberts, John W. Bigbee, David A. Gewirtz, M. Imad Damaj
Summary: This study demonstrates the preventive effect of curcumin and its lecithin formulation Meriva on paclitaxel-induced peripheral neuropathy. It also confirms the anti-inflammatory effects of curcumin through the activation of alpha 7 nAChRs receptors.
Article
Biochemistry & Molecular Biology
Adrien de Guilhem de Lataillade, Martial Caillaud, Thibauld Oullier, Philippe Naveilhan, Carolina Pellegrini, Eduardo Tolosa, Michel Neunlist, Malvyne Rolli-Derkinderen, Ellen Gelpi, Pascal Derkinderen
Summary: The LRRK2 gene is associated with both Parkinson's disease (PD) and Crohn's disease, suggesting its role in gastrointestinal inflammation. However, there is limited research on LRRK2 in the enteric nervous system (ENS). This study characterizes LRRK2 expression in the ENS, revealing its presence in enteric glial cells and identifying the cAMP pathway as a key regulator of LRRK2 expression in these cells. The findings provide a basis for further understanding the functions of LRRK2 in the ENS and investigating pathological changes in enteric synucleinopathies.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Behavioral Sciences
Alyssa White, Martial Caillaud, Moriah Carper, Justin Poklis, Michael F. Miles, M. Imad Damaj
Summary: This study investigated the strain and sex differences in acute alcohol-induced analgesia using C57BL/6 J (B6) and DBA/2 J (D2) mice. The results showed that alcohol had an analgesic effect in male mice of both strains, but not in female mice. D2 male mice were more sensitive to the analgesic effect of alcohol, and both strains of male mice developed tolerance to this effect after repeated administration of alcohol. These findings suggest that the analgesic effects of alcohol are influenced by genetic and sex factors.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Wisam Toma, Jason J. Paris, Urszula O. Warncke, Sara R. Nass, Martial Caillaud, Bryan McKiver, Olivia Ondo, Deniz Bagdas, John Bigbee, Pamela E. Knapp, Kurt F. Hauser, M. Imad Damaj
Summary: This study aims to investigate the role of chronic HIV-1 Tat exposure in the development of neuropathy in mice. The results show that Tat induces mechanical and cold hypersensitivity, with females exhibiting more severe hypersensitivity. Current therapeutics have limited effectiveness in alleviating symptoms in female mice.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Zeina Msheik, Stephanie Durand, Emilie Pinault, Martial Caillaud, Laetitia Vignaud, Fabrice Billet, Mohamed El Massry, Alexis Desmouliere
Summary: This study compared the sensorimotor and histological aspects of peripheral neuropathies in two rat models, sciatic nerve crush and Charcot-Marie-Tooth-1A (CMT1A) disease. Protein analysis revealed common pathological pathways between these two diseases and identified potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Martial Caillaud, Morgane E. Le Drean, Adrien De-Guilhem-de-Lataillade, Catherine Le Berre-Scoul, Jerome Montnach, Steven Nedellec, Gildas Loussouarn, Vincent Paille, Michel Neunlist, Helene Boudin
Summary: The enteric nervous system (ENS) is important for regulating digestive functions, but there is a lack of experimental models to understand its underlying mechanisms. In this study, a new model of highly pure rat embryonic enteric neurons with functional synaptic networks was developed. The model was characterized using various approaches and demonstrated applicability for monitoring enteric neuronal network activity. This in vitro model provides a valuable tool for studying the establishment and maintenance of enteric neuron synaptic connectivity and functional networks.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Nathan P. Staff, Sybil C. Hrstka, Surendra Dasari, Enrico Capobianco, Sandra Rieger
Summary: This study investigated the effects of paclitaxel therapy on the skin of breast cancer patients with chemotherapy-induced peripheral neuropathy (CIPN). Neurological examinations, quality of life questionnaires, and skin punch biopsies were conducted, revealing no significant difference in intraepidermal nerve fiber (IENF) density between control and CIPN patients. However, RNA sequencing and immunostaining showed upregulated MMP-13 expression and ultrastructural changes in collagen and basement membrane structures.
Article
Computer Science, Information Systems
Anthony M. Cirrincione, Cassandra A. Reimonn, Benjamin J. Harrison, Sandra Rieger
Summary: Paclitaxel-induced peripheral neuropathy is a nerve degenerative condition caused by chemotherapy, with no effective therapeutic interventions currently available. By studying gene expression changes in a mouse model, potential targets for drug development to prevent or reverse peripheral neuropathy induced by paclitaxel have been identified.
Meeting Abstract
Clinical Neurology
M. Imad Damaj, Martial Caillaud, Hamid Akbarali
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)