Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

(2019) Benjamin E. Willcox et al.   NATURE IMMUNOLOGY

Epithelial ovarian cancer

(2019) Stephanie Lheureux et al.   LANCET

Graft γδ TCR Sequencing Identifies Public Clonotypes Associated with Hematopoietic Stem Cell Transplantation Efficacy in Acute Myeloid Leukemia Patients and Unravels Cytomegalovirus Impact on Repertoire Distribution

(2019) Lucas C. M. Arruda et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo Expanded Human Vγ9Vδ2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth

(2019) Tsui Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment

(2019) Xian Chen et al.   Journal of Translational Medicine

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance

(2019) Adrian C. Hayday   JOURNAL OF IMMUNOLOGY

High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire

(2019) Biagio Di Lorenzo et al.   Scientific Data

TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells

(2019) Maria Papadopoulou et al.   JOURNAL OF IMMUNOLOGY

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

(2019) Zsolt Sebestyen et al.   NATURE REVIEWS DRUG DISCOVERY

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

(2019) Xian-Yang Li et al.   Cancer Discovery

Bispecific antibodies enhance tumor‐infiltrating T cell cytotoxicity against autologous HER‐2‐expressing high‐grade ovarian tumors

(2019) Hans‐Heinrich Oberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

(2018) Stuart Hunter et al.   JOURNAL OF HEPATOLOGY

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer

(2018) Emelie Rådestad et al.   OncoImmunology

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

The Ambiguous Role of γδ T Lymphocytes in Antitumor Immunity

(2017) Guranda Chitadze et al.   TRENDS IN IMMUNOLOGY

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage

(2017) Elena Lo Presti et al.   Cancer Immunology Research

What Else Can CD39 Tell Us?

(2017) Hai Zhao et al.   Frontiers in Immunology

Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer

(2017) Jieti Wang et al.   OncoImmunology

Tumor-infiltrating CD39+ γδTregs are novel immunosuppressive T cells in human colorectal cancer

(2017) Guoming Hu et al.   OncoImmunology

Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays

(2017) Marie Tosolini et al.   OncoImmunology

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

(2017) S. Meraviglia et al.   OncoImmunology

IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients

(2016) Rushikesh Sudam Patil et al.   INTERNATIONAL JOURNAL OF CANCER

Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens

(2016) Georg Gruenbacher et al.   Cell Reports

A Public Database of Memory and Naive B-Cell Receptor Sequences

(2016) William S. DeWitt et al.   PLoS One

tcR: an R package for T cell receptor repertoire advanced data analysis

(2015) Vadim I. Nazarov et al.   BMC BIOINFORMATICS

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

(2015) Martin Turcotte et al.   CANCER RESEARCH

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

(2015) Mateusz Legut et al.   Cellular & Molecular Immunology

Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral Infection

(2015) William S. DeWitt et al.   JOURNAL OF VIROLOGY

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires

(2015) Mikhail Shugay et al.   PLoS Computational Biology

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

(2014) Florencia McAllister et al.   CANCER CELL

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Adoptive Immunotherapy of Epithelial Ovarian Cancer with Vγ9Vδ2 T Cells, Potentiated by Liposomal Alendronic Acid

(2014) Ana C. Parente-Pereira et al.   JOURNAL OF IMMUNOLOGY

Murine CD27(-) V 6(+)    T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

(2014) M. Rei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

(2014) J. Bastid et al.   Cancer Immunology Research

Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment

(2014) Elena Lo Presti et al.   Frontiers in Immunology

Using synthetic templates to design an unbiased multiplex PCR assay

(2013) Christopher S. Carlson et al.   Nature Communications

Prognostic Value of Residual Tumor Size in Patients With Epithelial Ovarian Cancer FIGO Stages IIA–IV

(2012) Stephan Polterauer et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Tumor-Infiltrating    T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

(2012) C. Ma et al.   JOURNAL OF IMMUNOLOGY

Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas

(2012) Adriana Cordova et al.   PLoS One

Differentiation, phenotype, and function of interleukin-17-producing human V 9V 2 T cells

(2011) N. Caccamo et al.   BLOOD

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

(2011) Wei-Ting Hwang et al.   GYNECOLOGIC ONCOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Deep Sequencing of the Human TCR  and TCR  Repertoires Suggests that TCR  Rearranges After    and    T Cell Commitment

(2011) A. M. Sherwood et al.   Science Translational Medicine

Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

(2010) Daiko Wakita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY