TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function

Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity

(2020) Qiang Shan et al.   Cellular & Molecular Immunology

β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

(2020) Xin Zhao et al.   eLife

Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells

(2019) Shaojun Xing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection

(2019) Peng Shao et al.   JOURNAL OF IMMUNOLOGY

The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage

(2019) Christelle Harly et al.   NATURE IMMUNOLOGY

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

(2019) Bi-Huei Yang et al.   Cell Reports

Immunization: vital progress, unfinished agenda

(2019) Peter Piot et al.   NATURE

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

(2019) Dinesh Raghu et al.   TRENDS IN IMMUNOLOGY

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells

(2018) John L. Johnson et al.   IMMUNITY

TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner

(2018) Jing Zhang et al.   JOURNAL OF IMMUNOLOGY

T Follicular Helper Cells in Autoimmune Disorders

(2018) Noémie Gensous et al.   Frontiers in Immunology

Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity

(2018) Shaojun Xing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

(2018) Fengyin Li et al.   Nature Communications

Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4

(2017) Bi Shi et al.   JOURNAL OF IMMUNOLOGY

Differential Requirements for Tcf1 Long Isoforms in CD8+and CD4+T Cell Responses to Acute Viral Infection

(2017) Jodi A. Gullicksrud et al.   JOURNAL OF IMMUNOLOGY

Co-stimulatory and Co-inhibitory Pathways in Autoimmunity

(2016) Qianxia Zhang et al.   IMMUNITY

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

Targeting T Cell Co-receptors for Cancer Therapy

(2016) Margaret K. Callahan et al.   IMMUNITY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity

(2016) Shaojun Xing et al.   NATURE IMMUNOLOGY

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway

(2016) Selvi Ramasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Groucho/Transducin-like enhancer of split protein family in animal development

(2015) Megha Agarwal et al.   IUBMB LIFE

The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection

(2015) Lifan Xu et al.   NATURE IMMUNOLOGY

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

(2015) Youn Soo Choi et al.   NATURE IMMUNOLOGY

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

(2015) Tuoqi Wu et al.   Cell Reports

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells

(2014) Farrah C. Steinke et al.   IMMUNOLOGIC RESEARCH

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

(2014) Haikun Wang et al.   NATURE IMMUNOLOGY

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

The Corepressor Tle4 Is a Novel Regulator of Murine Hematopoiesis and Bone Development

(2014) Justin C. Wheat et al.   PLoS One

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

(2014) Chun Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TCF-1 and LEF-1 Transcription Factors Have Cooperative and Opposing Roles in T Cell Development and Malignancy

(2012) Shuyang Yu et al.   IMMUNITY

Cutting Edge: Generation of Memory Precursors and Functional Memory CD8+ T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1

(2012) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ

(2009) Qing Yu et al.   NATURE IMMUNOLOGY