Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF

A Peroxodiiron(III/III) Intermediate Mediating Both N-Hydroxylation Steps in Biosynthesis of the N-Nitrosourea Pharmacophore of Streptozotocin by the Multi-domain Metalloenzyme SznF

(2020) Molly J. McBride et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Soluble Methane Monooxygenase

(2019) Rahul Banerjee et al.   Annual Review of Biochemistry

Discovery of a pathway for terminal-alkyne amino acid biosynthesis

(2019) J. A. Marchand et al.   NATURE

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

(2019) Tai L. Ng et al.   NATURE

Two-Enzyme Pathway Links l-Arginine to Nitric Oxide in N-Nitroso Biosynthesis

(2019) Hai-Yan He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The oxidative decarboxylase UndA utilizes a dinuclear iron cofactor

(2019) Olivia M. Manley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vitro Reconstitution of the Biosynthetic Pathway to the Nitroimidazole Antibiotic Azomycin

(2019) Jason B. Hedges et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

(2019) Liao-Bin Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA

(2019) Bo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria

(2019) Ron Hermenau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways

(2019) Rémi Zallot et al.   BIOCHEMISTRY

Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes

(2018) Andrew J. Jasniewski et al.   CHEMICAL REVIEWS

Diiron monooxygenases in natural product biosynthesis

(2018) Anna J. Komor et al.   NATURAL PRODUCT REPORTS

The biosynthesis of methanobactin

(2018) Grace E. Kenney et al.   SCIENCE

Biosynthesis of fragin is controlled by a novel quorum sensing signal

(2018) Christian Jenul et al.   Nature Communications

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

(2018) Ron Hermenau et al.   Nature Chemical Biology

Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas

(2018) Ashley M. Kretsch et al.   ORGANIC LETTERS

Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF

(2017) Kiyoung Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

(2017) Andrew J. Jasniewski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In-crystal reaction cycle of a toluene-bound diiron hydroxylase

(2017) Justin F. Acheson et al.   NATURE

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

(2016) Cory J. Knoot et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway

(2015) Thomas M. Makris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination

(2015) Zhenggang Han et al.   STRUCTURE

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase

(2014) Zhe Rui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous and Adaptable Enzymes Fill "Holes" in the Tetrahydrofolate Pathway in Chlamydia Species

(2014) N. E. Adams et al.   mBio

Dioxygen Activation in Soluble Methane Monooxygenase

(2011) Christine E. Tinberg et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mechanistic Studies of Reactions of Peroxodiiron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase

(2011) Woon Ju Song et al.   BIOCHEMISTRY

Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus

(2010) N. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Mechanism of Dioxygen Activation in Soluble Methane Monooxygenase fromM. capsulatus(Bath): Evidence for a Multi-Step, Proton-Dependent Reaction Pathway

(2009) Christine E. Tinberg et al.   BIOCHEMISTRY

A Long-Lived, Substrate-Hydroxylating Peroxodiiron(III/III) Intermediate in the Amine Oxygenase, AurF, fromStreptomyces thioluteus

(2009) Victoria Korneeva Korboukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

(2008) Y. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY