A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

(2020) Matthew G. Costales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

(2019) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

(2019) Alicia J. Angelbello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cross-linking approach to map small molecule-RNA binding sites in cells

(2019) Sai Pradeep Velagapudi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

(2019) Yujia Wang et al.   Nature Chemistry

Diazirine-containing tag-free RNA probes for efficient RISC-loading and photoaffinity labeling of microRNA targets

(2018) Kosuke Nakamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanistic studies of a small-molecule modulator of SMN2 splicing

(2018) Jingxin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RNA in mammalian systems with small molecules

(2018) Anita Donlic et al.   Wiley Interdisciplinary Reviews-RNA

Fragment-to-Lead Medicinal Chemistry Publications in 2017

(2018) Paul N. Mortenson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current perspectives in fragment-based lead discovery (FBLD)

(2017) Bas Lamoree et al.   Essays in Biochemistry

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

(2017) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence

(2016) Matthew D. Disney et al.   ACCOUNTS OF CHEMICAL RESEARCH

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

Labeling of target mRNAs using a photo-reactive microRNA probe

(2016) Kosuke Nakamoto et al.   CHEMICAL COMMUNICATIONS

Precise small-molecule recognition of a toxic CUG RNA repeat expansion

(2016) Suzanne G Rzuczek et al.   Nature Chemical Biology

Twenty years on: the impact of fragments on drug discovery

(2016) Daniel A. Erlanson et al.   NATURE REVIEWS DRUG DISCOVERY

Design of a small molecule against an oncogenic noncoding RNA

(2016) Sai Pradeep Velagapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

(2016) Wang-Yong Yang et al.   Nature Communications

Small molecules targeting viral RNA

(2016) Thomas Hermann   Wiley Interdisciplinary Reviews-RNA

Structure based approaches for targeting non-coding RNAs with small molecules

(2015) Matthew D Shortridge et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Diazirine-Containing RNA Photo-Cross-Linking Probes for Capturing microRNA Targets

(2014) Kosuke Nakamoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Landscape and variation of RNA secondary structure across the human transcriptome

(2014) Yue Wan et al.   NATURE

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

Features of Modularly Assembled Compounds That Impart Bioactivity Against an RNA Target

(2013) Suzanne G. Rzuczek et al.   ACS Chemical Biology

Targeting the Production of Oncogenic MicroRNAs with Multimodal Synthetic Small Molecules

(2013) Duc Duy Vo et al.   ACS Chemical Biology

Covalent Small-Molecule-RNA Complex Formation Enables Cellular Profiling of Small-Molecule-RNA Interactions

(2013) Lirui Guan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting a c-MYC G-quadruplex DNA with a fragment library

(2013) Hamid R. Nasiri et al.   CHEMICAL COMMUNICATIONS

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

(2013) Yiliang Ding et al.   NATURE

Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive

(2012) Jessica L. Childs-Disney et al.   ACS Chemical Biology

Fragment-Based Approaches in Drug Discovery and Chemical Biology

(2012) Duncan E. Scott et al.   BIOCHEMISTRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Using Modularly Assembled Ligands To Bind RNA Internal Loops Separated by Different Distances

(2011) Jessica L. Childs-Disney et al.   CHEMBIOCHEM

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble

(2011) Andrew C Stelzer et al.   Nature Chemical Biology

Apoptosis and the target genes of microRNA-21

(2011) Lindsey E. Becker Buscaglia et al.   Chinese Journal of Cancer

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Ligand efficiency and fragment-based drug discovery

(2008) Scott D. Bembenek et al.   DRUG DISCOVERY TODAY

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE