Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review
Authors
Keywords
Organoruthenium, Binuclear Ru complex, DNA targeting, Mechanism of action, ROS
Journal
POLYHEDRON
Volume 192, Issue -, Pages 114827
Publisher
Elsevier BV
Online
2020-10-06
DOI
10.1016/j.poly.2020.114827
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands
- (2020) Alexandra-Cristina Munteanu et al. INORGANIC CHEMISTRY
- Effect of N,N Coordination and RuII Halide Bond in Enhancing Selective Toxicity of a Tyramine-Based RuII (p-Cymene) Complex
- (2020) Arpan Mukherjee et al. INORGANIC CHEMISTRY
- Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
- (2019) Reece G. Kenny et al. CHEMICAL REVIEWS
- Synthesis, spectral studies, DNA binding, photocleavage, antimicrobial and anticancer activities of isoindol Ru(II) polypyridyl complexes
- (2019) Ch. Ravi et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Synthesis, Structure, Stability, and Inhibition of Tubulin Polymerization by RuII–p-Cymene Complexes of Trimethoxyaniline-Based Schiff Bases
- (2019) Sourav Acharya et al. INORGANIC CHEMISTRY
- Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging
- (2019) Xingxing Ge et al. APPLIED ORGANOMETALLIC CHEMISTRY
- Near-IR/Visible-Emitting Thiophenyl-Based Ru(II) Complexes: Efficient Photodynamic Therapy, Cellular Uptake, and DNA Binding
- (2019) Si-Qi Zhang et al. INORGANIC CHEMISTRY
- Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(III) Complexes Based on the Androst-16-en-3-ol Framework
- (2019) Vanessa Koch et al. INORGANIC CHEMISTRY
- Ruthenium arene complex induces cell cycle arrest and apoptosis through activation of P53-mediated signaling pathways
- (2019) Jianfu Zhao et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Making the Right Link to Theranostics: The Photophysical and Biological Properties of Dinuclear RuII–ReI dppz Complexes Depend on Their Tether
- (2019) Hiwa K. Saeed et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies
- (2019) Guang-Bin Jiang et al. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and apoptosis in breast and prostate tumor cells
- (2019) Israel Higino de Sousa et al. TOXICOLOGY IN VITRO
- A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression
- (2018) Swapan S. Jain et al. CHEMICAL COMMUNICATIONS
- N- and S-donor leaving groups in triazole-based ruthena(ii)cycles: potent anticancer activity, selective activation, and mode of action studies
- (2018) Christoph A. Riedl et al. DALTON TRANSACTIONS
- Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential
- (2018) Leonor Côrte-Real et al. INORGANIC CHEMISTRY
- Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features
- (2018) JuanJuan Li et al. INORGANIC CHEMISTRY
- Photolabile ruthenium complexes to cage and release a highly cytotoxic anticancer agent
- (2018) Jianhua Wei et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?
- (2018) Sreekanth Thota et al. JOURNAL OF MEDICINAL CHEMISTRY
- Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes
- (2018) Mun Juinn Chow et al. MOLECULAR PHARMACEUTICS
- Studies on the DNA binding and anticancer activity of Ru(ii) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
- (2018) Ravi Kumar Vuradi et al. NEW JOURNAL OF CHEMISTRY
- Phosphine/diimine ruthenium complexes with Cl − , CO, NO + , NO 2 − , NO 3 − and pyridine ligands: Pro-apoptotic activity on triple-negative breast cancer cells and DNA/HSA interactions
- (2018) Henrique Vieira Reis Silva et al. POLYHEDRON
- Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy
- (2018) Zhixuan Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A comparative study on in vitro cytotoxicity, cellular uptake, localization and apoptosis-inducing mechanism of two ruthenium(II) complexes
- (2018) Jincan Chen et al. TRANSITION METAL CHEMISTRY
- Mitochondria-targeted half-sandwich rutheniumII diimine complexes: anticancer and antimetastasis via ROS-mediated signalling
- (2018) Zhishan Xu et al. Inorganic Chemistry Frontiers
- Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells
- (2018) Zhenzhen Tian et al. INORGANIC CHEMISTRY
- Potent Half-Sandwich Iridium(III) and Ruthenium(II) Anticancer Complexes Containing a P^O-Chelated Ligand
- (2018) Qing Du et al. ORGANOMETALLICS
- Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
- (2018) Susan Monro et al. CHEMICAL REVIEWS
- Half-Sandwich Iridium and Ruthenium Complexes: Effective Tracking in Cells and Anticancer Studies
- (2018) JuanJuan Li et al. INORGANIC CHEMISTRY
- Strong Influence of Ancillary Ligands Containing Benzothiazole or Benzimidazole Rings on Cytotoxicity and Photoactivation of Ru(II) Arene Complexes
- (2018) Matteo Lari et al. INORGANIC CHEMISTRY
- Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct- [RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine], by in vitro and in vivo assays
- (2018) Andréa P. Carnizello et al. JOURNAL OF APPLIED TOXICOLOGY
- Exploring the cytotoxicity, uptake, cellular response, and proteomics of mono- and dinuclear DNA light-switch complexes
- (2018) Paul James Jarman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Newly Synthesized Heteronuclear Ruthenium(II)/Ferrocene Complexes Suppress the Growth of Mammary Carcinoma in 4T1-Treated BALB/c Mice by Promoting Activation of Antitumor Immunity
- (2018) Milan M. Milutinović et al. ORGANOMETALLICS
- Ruthenium(II) complexes of saccharin with dipyridoquinoxaline and dipyridophenazine: Structures, biological interactions and photoinduced DNA damage activity
- (2017) Priyaranjan Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, characterization, cellular uptake and apoptosis-inducing properties of two highly cytotoxic cyclometalated ruthenium(II) β-carboline complexes
- (2017) Jincan Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption
- (2017) Dan Wan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Photobiological Activity of Ru(II) Dyads Derived from Pyrrole-2-carboxylate Thionoesters
- (2017) Deborah A. Smithen et al. INORGANIC CHEMISTRY
- New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent
- (2017) Antonella Guerriero et al. INORGANIC CHEMISTRY
- Synthesis, characterization, DNA binding and cytotoxicity of fluoro-dipyrrin based arene ruthenium(II) complexes
- (2017) Rajendra Prasad Paitandi et al. INORGANICA CHIMICA ACTA
- Ruthenium(II)-arene complexes with dibenzoylmethane induce apoptotic cell death in multiple myeloma cell lines
- (2017) Riccardo Pettinari et al. INORGANICA CHIMICA ACTA
- Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells
- (2017) Xuan Truong et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- New 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine ruthenium(II) complexes: Synthesis, characterization, interaction with DNA/BSA and cytotoxicity studies
- (2017) Milan M. Milutinović et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- New ruthenium compounds bearing semicarbazone 2-formylopyridine moiety: Playing with auxiliary ligands for tuning the mechanism of biological activity
- (2017) Michał Łomzik et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity
- (2017) João Lopes et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
- (2017) Sabyasachi Chakrabortty et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity
- (2017) Robert H. Berndsen et al. Scientific Reports
- Ruthenium(II) complexes containing 4-methoxybenzhydrazone ligands: synthesis, characterization, DNA binding, DNA cleavage, radical scavenging andin vitrocytotoxic activity
- (2016) Maruthachalam Mohanraj et al. APPLIED ORGANOMETALLIC CHEMISTRY
- Heterodinuclear Pt(iv)–Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis
- (2016) Lili Ma et al. CHEMICAL COMMUNICATIONS
- Overcoming the Achilles' heel of photodynamic therapy
- (2016) Wenpei Fan et al. CHEMICAL SOCIETY REVIEWS
- Substituent effect and wavelength dependence of the photoinduced Ru–O homolysis in the [Ru(bpy)2(py-SO3)]+-type complexes
- (2016) Yue Zheng et al. DALTON TRANSACTIONS
- The induction of apoptosis in HepG-2 cells by ruthenium(II) complexes through an intrinsic ROS-mediated mitochondrial dysfunction pathway
- (2016) Chuan-Chuan Zeng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
- (2016) Christoph A. Riedl et al. INORGANIC CHEMISTRY
- Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines
- (2016) Jun Du et al. INORGANIC CHEMISTRY
- Synthesis, characterization, and antitumor properties of ruthenium(II) anthraquinone complexes
- (2016) Jin-Quan Wang et al. JOURNAL OF COORDINATION CHEMISTRY
- Synthesis, characterization and biological evaluation of novel Ru(II)–arene complexes containing intercalating ligands
- (2016) Stefan Nikolić et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Biodistribution of the novel anticancer drug sodium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
- (2016) Anna K. Bytzek et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Ruthenium(II) polypyridyl complexes with 1,8-naphthalimide group as DNA binder, photonuclease, and dual inhibitors of topoisomerases I and IIα
- (2016) Yanmei Sun et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex
- (2016) Viktor Brabec et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis
- (2016) Legna Colina-Vegas et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- The studies on the cytotoxicity in vitro, cellular uptake, cell cycle arrest and apoptosis-inducing properties of ruthenium methylimidazole complex [Ru(MeIm)4(p-cpip)]2+
- (2016) Lan-mei Chen et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Synthesis, characterization and biological activities of some Ru(II) complexes with substituted chalcones and their applications as chemotherapeutics against breast cancer
- (2016) Ashok K. Singh et al. JOURNAL OF MOLECULAR STRUCTURE
- Inhibition of cancer cell growth by ruthenium complexes
- (2016) Joji Iida et al. Journal of Translational Medicine
- Tri- and tetranuclear RuII–GdIII2 and RuII–GdIII3 d–f heterometallic complexes as potential bimodal imaging probes for MRI and optical imaging
- (2016) A. Nithyakumar et al. NEW JOURNAL OF CHEMISTRY
- The water soluble ruthenium(II) organometallic compound [Ru( p -cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells
- (2016) Maura Montani et al. PHARMACOLOGICAL RESEARCH
- Synthesis, cytotoxicity in vitro, apoptosis, cell cycle arrest and comet assay of asymmetry ruthenium(II) complexes
- (2016) Cheng Zhang et al. POLYHEDRON
- Use of 1,2,4-triazolo[1,5-a]pyrimidines to design new “piano-stool” ruthenium(II) compounds
- (2016) Iwona Łakomska et al. POLYHEDRON
- The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex
- (2016) Lanmei Chen et al. Oncotarget
- Synthesis, structures, and DNA and protein binding of ruthenium(ii)-p-cymene complexes of substituted pyridylimidazo[1,5-a]pyridine: enhanced cytotoxicity of complexes of ligands appended with a carbazole moiety
- (2016) Themmila Khamrang et al. RSC Advances
- Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer
- (2016) Matthew Dickerson et al. Journal of Materials Chemistry B
- Antimetastatic activity of novel ruthenium (III) pyridine complexes
- (2016) Liwei Gu et al. Cancer Medicine
- Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
- (2015) Huaiyi Huang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis, characterization and catalytic, cytotoxic and antimicrobial activities of two novel cyclotriphosphazene-based multisite ligands and their Ru(II) complexes
- (2015) Diğdem Erdener Çıralı et al. APPLIED ORGANOMETALLIC CHEMISTRY
- Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
- (2015) Jiangping Liu et al. BIOMATERIALS
- Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
- (2015) Leli Zeng et al. CHEMISTRY-A EUROPEAN JOURNAL
- A Cytostatic Ruthenium(II)-Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into S Phase by Up-regulating p27KIP1
- (2015) Vadde Ramu et al. CHEMISTRY-A EUROPEAN JOURNAL
- Synthesis, relaxivity, and in vitro fluorescence imaging studies of a novel d–f heterometallic trinuclear complex as a potential bimodal imaging probe for MRI and optical imaging
- (2015) A. Nithyakumar et al. DALTON TRANSACTIONS
- Two novel BODIPY–Ru(ii) arene dyads enabling effective photo-inactivation against cancer cells
- (2015) Tianji Wang et al. DALTON TRANSACTIONS
- Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(ii) complexes for photodynamic therapy
- (2015) Huaiyi Huang et al. DALTON TRANSACTIONS
- Design, synthesis and characterisation of new chimeric ruthenium(ii)–gold(i) complexes as improved cytotoxic agents
- (2015) Lara Massai et al. DALTON TRANSACTIONS
- Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates
- (2015) Gary J. Ryan et al. DALTON TRANSACTIONS
- Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents
- (2015) Gaochao Lv et al. DALTON TRANSACTIONS
- Restoration of mitochondria function as a target for cancer therapy
- (2015) Tariq A. Bhat et al. DRUG DISCOVERY TODAY
- Towards Selective Light-Activated RuII-Based Prodrug Candidates
- (2015) Cristina Mari et al. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
- Ruthenium(II)-arene complexes with naphthalimide-tagged N,O- and N,N-chelating ligands: Synthesis and biological evaluation
- (2015) Kesete Ghebreyessus et al. INORGANICA CHIMICA ACTA
- Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents
- (2015) Chengxi Wang et al. JOURNAL OF COORDINATION CHEMISTRY
- The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
- (2015) Leonor Côrte-Real et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA
- (2015) Dongdong Sun et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- The 1,3-diaryltriazenido( p -cymene)ruthenium(II) complexes with a high in vitro anticancer activity
- (2015) Jure Vajs et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Ruthenium(II) p -cymene complex bearing 2,2′-dipyridylamine targets caspase 3 deficient MCF-7 breast cancer cells without disruption of antitumor immune response
- (2015) Goran N. Kaluđerović et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Modulating the Anticancer Activity of Ruthenium(II)–Arene Complexes
- (2015) Catherine M. Clavel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure–Activity Relationship Study
- (2015) Jyoti Yellol et al. JOURNAL OF MEDICINAL CHEMISTRY
- Ruthenium complex Λ-WH0402 induces hepatocellular carcinoma LM6 (HCCLM6) cell death by triggering the Beclin-1-dependent autophagy pathway
- (2015) Jian Yuan et al. Metallomics
- Synthesis, characterization and anticancer activity of dinuclear ruthenium(ii) complexes linked by an alkyl chain
- (2015) Yan Zhang et al. NEW JOURNAL OF CHEMISTRY
- Synthesis, Structures, and Biological Studies of Heterobimetallic Au(I)–Ru(II) Complexes Involving N-Heterocyclic Carbene-Based Multidentate Ligands
- (2015) Luca Boselli et al. ORGANOMETALLICS
- A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors
- (2015) Jamie Fong et al. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
- A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
- (2015) Eleftherios K. Pefkianakis et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Synthesis, characterization, crystal structure, cytotoxicity, apoptosis and cell cycle arrest of ruthenium(ii) complex [Ru(bpy)2(adpa)](PF6)2 (bpy = 2,2′-bipyridine, adpa = 4-(4-aminophenyl)diazenyl-N-(pyridin-2-ylmethylene)aniline)
- (2015) Yan Zhang et al. RSC Advances
- Ruthenium Polypyridyl Complex Inhibits Growth and Metastasis of Breast Cancer Cells by Suppressing FAK signaling with Enhancement of TRAIL-induced Apoptosis
- (2015) Wenqiang Cao et al. Scientific Reports
- Identification and discrimination of binding sites of an organoruthenium anticancer complex to single-stranded oligonucleotides by mass spectrometry
- (2014) Suyan Liu et al. ANALYST
- Targeting DNA damage response in cancer therapy
- (2014) Noriko Hosoya et al. CANCER SCIENCE
- Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics
- (2014) Ruizheng Liang et al. CHEMICAL COMMUNICATIONS
- Dinuclear [{(p-cym)RuCl}2(μ-phpy)](PF6)2 and heterodinuclear [(ppy)2Ir(μ-phpy)Ru(p-cym)Cl](PF6)2 complexes: synthesis, structure and anticancer activity
- (2014) Suman Kumar Tripathy et al. DALTON TRANSACTIONS
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks
- (2014) Matthew Dickerson et al. INORGANIC CHEMISTRY
- Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer
- (2014) Lydia E. H. Paul et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Thermodynamic Investigations of [(phen)2Ru(tatpp)Ru(phen)2]4+ Interactions with B-DNA
- (2014) Vu H. Le et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Metallomics insights into the programmed cell death induced by metal-based anticancer compounds
- (2014) Cai-Ping Tan et al. Metallomics
- Multinuclear ruthenium(ii) complexes as anticancer agents
- (2014) Anil K. Gorle et al. NEW JOURNAL OF CHEMISTRY
- NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- (2014) Robert Trondl et al. Chemical Science
- Chiral ruthenium(ii) complexes with phenolic hydroxyl groups as dual poisons of topoisomerases I and IIα
- (2013) Pingyu Zhang et al. DALTON TRANSACTIONS
- Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells
- (2013) Jin-Quan Wang et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes
- (2013) Chen Qian et al. Metallomics
- Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(ii) polypyridyl complex
- (2013) Martin R. Gill et al. Chemical Science
- Identification of fluorescent ruthenium complexes containing imidazole derivatives as a new class of apoptosis inducers by living cell real-time imaging
- (2013) Yanan Liu et al. MedChemComm
- Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics
- (2012) Martin R. Gill et al. CHEMICAL SOCIETY REVIEWS
- Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
- (2012) Gerhard Mühlgassner et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics
- (2012) Annie Castonguay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, characterization, DNA-binding and cytotoxic properties of Ru(II) complexes: [Ru(MeIm)4L]2+ (MeIm=1-methylimidazole, L=phen, ip and pip)
- (2012) Leli Zeng et al. JOURNAL OF MOLECULAR STRUCTURE
- Chemistry of DNA minor groove binding agents
- (2012) Gul Shahzada Khan et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid
- (2012) Vanessa Pierroz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Naphthalimide-Tagged Ruthenium–Arene Anticancer Complexes: Combining Coordination with Intercalation
- (2012) Kelly J. Kilpin et al. ORGANOMETALLICS
- Tumor Metastasis: Molecular Insights and Evolving Paradigms
- (2011) Scott Valastyan et al. CELL
- Anticancer activity of tetracationic arene ruthenium metalla-cycles
- (2011) Nicolas P. E. Barry et al. DALTON TRANSACTIONS
- Natural product DNA major groove binders
- (2011) Paris L. Hamilton et al. NATURAL PRODUCT REPORTS
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
- (2011) Shankar Balasubramanian et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting a ruthenium complex to the nucleus with short peptides
- (2010) Cindy A. Puckett et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Ruthenium-based chemotherapeutics: are they ready for prime time?
- (2010) Emmanuel S. Antonarakis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The status of platinum anticancer drugs in the clinic and in clinical trials
- (2010) Nial J. Wheate et al. DALTON TRANSACTIONS
- Development of Bimetallic Titanocene−Ruthenium−Arene Complexes As Anticancer Agents: Relationships between Structural and Biological Properties
- (2010) Frédéric Pelletier et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis
- (2010) Caiping Tan et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
- (2009) Xiangjun Meng et al. CANCER RESEARCH
- A Cytotoxic Ruthenium Tris(Bipyridyl) Complex that Accumulates at Plasma Membranes
- (2009) Olivier Zava et al. CHEMBIOCHEM
- Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications
- (2009) Lema F. Yousif et al. CHEMBIOCHEM
- A categorization of metal anticancer compounds based on their mode of action
- (2009) Teresa Gianferrara et al. DALTON TRANSACTIONS
- Nuclear targets of photodynamic tridentate ruthenium complexes
- (2009) Ran Zhao et al. DALTON TRANSACTIONS
- Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
- (2009) Sanja Grgurić-Šipka et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity
- (2009) Maria G. Mendoza-Ferri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fluorescein Redirects a Ruthenium−Octaarginine Conjugate to the Nucleus
- (2009) Cindy A. Puckett et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells
- (2009) Martin R. Gill et al. Nature Chemistry
- Targeting Mitochondria
- (2008) Adam T. Hoye et al. ACCOUNTS OF CHEMICAL RESEARCH
- KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- (2008) Christian G. Hartinger et al. CHEMISTRY & BIODIVERSITY
- Therapeutic Nanoparticles for Drug Delivery in Cancer
- (2008) K. Cho et al. CLINICAL CANCER RESEARCH
- The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways
- (2008) Soumya Chatterjee et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer
- (2008) Frédéric Schmitt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Influence of the Spacer Length on thein VitroAnticancer Activity of Dinuclear Ruthenium−Arene Compounds
- (2008) Maria-Grazia Mendoza-Ferri et al. ORGANOMETALLICS
- Luminescent Biological Probes Derived from Ruthenium(II) Estradiol Polypyridine Complexes
- (2007) Kenneth Kam-Wing Lo et al. INORGANIC CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More