Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α

A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation

(2020) Tomoya Sakamoto et al.   CIRCULATION RESEARCH

Mutations in ASPRV1 Cause Dominantly Inherited Ichthyosis

(2020) Lynn M. Boyden et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chronic inflammation in response to injury: retention of myeloid cells in injured tissue is driven by myeloid cell-intrinsic factors

(2019) Tanja Torbica et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

(2018) Daniel E Foxler et al.   EMBO Molecular Medicine

ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

(2018) Susana Cadenas   FREE RADICAL BIOLOGY AND MEDICINE

Psoriasis: A STAT3-Centric View

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3

(2017) Hengxun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia

(2017) Thomas Suply et al.   Science Signaling

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia

(2017) Thomas Suply et al.   Science Signaling

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Hypoxia induces voltage-gated K+ (Kv) channel expression in pulmonary arterial smooth muscle cells through hypoxia-inducible factor-1 (HIF-1)

(2017) Qian Dong et al.   Bosnian Journal of Basic Medical Sciences

Apolipoprotein E−/−Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage FunctionHighlights

(2016) Niyati U. Mehta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

(2016) YAO CUI et al.   ONCOLOGY REPORTS

Oxidation of K+Channels in Aging and Neurodegeneration

(2016) Federico Sesti   Aging and Disease

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters

(2015) Li Xu et al.   NUCLEIC ACIDS RESEARCH

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

(2015) Valeria Poli et al.   Frontiers in Oncology

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

(2014) D. J. Speca et al.   GENES BRAIN AND BEHAVIOR

Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2

(2014) Melissa L. Fishel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease

(2014) Long Truong Hoang et al.   Genome Medicine

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

(2013) Keunsoo Kang et al.   BMC GENOMICS

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

In vivoevidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli

(2013) Yael Nechemia-Arbely et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1

(2013) Matthew D. Galbraith et al.   NUCLEIC ACIDS RESEARCH

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

(2013) M R Pawlus et al.   ONCOGENE

Voltage-Gated Potassium Channels at the Crossroads of Neuronal Function, Ischemic Tolerance, and Neurodegeneration

(2013) Niyathi Hegde Shah et al.   Translational Stroke Research

Apelin Enhances Cardiac Neovascularization After Myocardial Infarction by Recruiting Aplnr+ Circulating Cells

(2012) Dennie Tempel et al.   CIRCULATION RESEARCH

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation

(2011) Xinyang Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury

(2011) Seán P. Barry et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

(2010) Kiyoshi Hirahara et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy

(2009) Hong Yue et al.   CARDIOVASCULAR RESEARCH

STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

(2009) Joo Eun Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3

(2009) F. Vallania et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein

(2008) Kishor K. Bhakat et al.   ANTIOXIDANTS & REDOX SIGNALING

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL