Drug-Induced Mitochondrial Toxicity

Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Archives of Medical Science

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Muscle-related side-effects of statins

(2015) Beth A. Taylor et al.   CURRENT OPINION IN LIPIDOLOGY

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

The role of mitochondria in statin-induced myopathy

(2015) Maria Apostolopoulou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation

(2015) Priscila A. de Faria et al.   TOXICOLOGY

Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model

(2015) Tuomas Komulainen et al.   TOXICOLOGY

Statin Intolerance

(2014) Zahid Ahmad   AMERICAN JOURNAL OF CARDIOLOGY

Antiretroviral Protease Inhibitors Accelerate Glutathione Export from Viable Cultured Rat Neurons

(2014) Maria Brandmann et al.   NEUROCHEMICAL RESEARCH

Statin-induced myopathies

(2014) Michał Tomaszewski et al.   Pharmacological Reports

Mechanisms of Phenytoin-Induced Toxicity in Freshly Isolated Rat Hepatocytes and the Protective Effects of Taurine and/or Melatonin

(2013) Mohammad Ali Eghbal et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Simvastatin Effects on Skeletal Muscle

(2013) Steen Larsen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Antiretroviral Protease Inhibitor Ritonavir Accelerates Glutathione Export from Cultured Primary Astrocytes

(2013) Christian Arend et al.   NEUROCHEMICAL RESEARCH

A Pragmatic View of the New Cholesterol Treatment Guidelines

(2013) John F. Keaney et al.   NEW ENGLAND JOURNAL OF MEDICINE

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Nucleoside Reverse Transcriptase Inhibitors Induce a Mitophagy-Associated Endothelial Cytotoxicity That Is Reversed by Coenzyme Q10 Cotreatment

(2013) Stephen Y. Xue et al.   TOXICOLOGICAL SCIENCES

Toxicity of valproic acid in isolated rat liver mitochondria

(2013) Iman Jafarian et al.   TOXICOLOGY MECHANISMS AND METHODS

Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability

(2013) Iris Usach et al.   Journal of the International AIDS Society

Effect of valproic acid on mitochondrial epigenetics

(2012) Hu Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment

(2012) Kate E. C. Duberley et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Valproate as a treatment for dopamine dysregulation syndrome (DDS) in Parkinson’s disease

(2012) Ashok Sriram et al.   JOURNAL OF NEUROLOGY

l-dopa-induced dopamine synthesis and oxidative stress in serotonergic cells

(2012) Branden J. Stansley et al.   NEUROPHARMACOLOGY

Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions

(2012) QiPing Feng et al.   PHARMACOGENOMICS

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

(2012) Yan Li et al.   TOXICOLOGICAL SCIENCES

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro inhibition of mitochondrial respiratory rate by antidepressants

(2012) Jana Hroudová et al.   TOXICOLOGY LETTERS

Enzyme inducing antiepileptic drugs are associated with mitochondrial proliferation and increased cytochrome c oxidase activity in muscle of children with epilepsy

(2011) Michael V. Miles et al.   EPILEPSY RESEARCH

Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients

(2011) Ana M. Moreno-Fernández et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

(2011) Brendan A I Payne et al.   NATURE GENETICS

Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson’s disease

(2011) C.W. Hicks et al.   PARKINSONISM & RELATED DISORDERS

Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs

(2010) Mario David Cordero et al.   ANTI-CANCER DRUGS

Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease

(2010) Marco Bisaglia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bezafibrate induced increase in mitochondrial electron transport chain complex IV activity in human astrocytoma cells: Implications for mitochondrial cytopathies and neurodegenerative diseases

(2010) Nicola Ioannou et al.   BIOFACTORS

Polymerase γ Gene POLG determines the risk of sodium valproate-induced liver toxicity

(2010) Joanna D. Stewart et al.   HEPATOLOGY

The Effect of Antiepileptic Drugs on Mitochondrial Activity: A Pilot Study

(2010) Itai Berger et al.   JOURNAL OF CHILD NEUROLOGY

Approach to the Patient Who Is Intolerant of Statin Therapy

(2010) Robert H. Eckel   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rosuvastatin Lowers Coenzyme Q10 Levels, but not Mitochondrial Adenosine Triphosphate Synthesis, in Children with Familial Hypercholesterolemia

(2010) Hans J. Avis et al.   JOURNAL OF PEDIATRICS

The Effects of Antidepressants on Mitochondrial Function in a Model Cell System and Isolated Mitochondria

(2010) W. Abdel-Razaq et al.   NEUROCHEMICAL RESEARCH

Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage

(2009) Rosilla F. Bachmann et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Diagnosis and therapy in neuromuscular disorders: diagnosis and new treatments in mitochondrial diseases

(2009) S Rahman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy

(2009) Asha R Kallianpur et al.   PHARMACOGENOMICS

Seizures, antiepileptics, antioxidants and oxidative stress: an insight for researchers

(2008) P Uma Devi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Medication‐induced mitochondrial damage and disease

(2008) John Neustadt et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Large-scale chemical dissection of mitochondrial function

(2008) Bridget K Wagner et al.   NATURE BIOTECHNOLOGY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver

(2008) N.A.G. Santos et al.   TOXICOLOGY IN VITRO

Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs

(2008) N.A.G. Santos et al.   TOXICOLOGY IN VITRO

Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment

(2008) Andrew J. Duncan et al.   TOXICOLOGY MECHANISMS AND METHODS

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology