Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

(2020) Sangeun Jeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

(2020) Ya-Nan Zhang et al.   Emerging Microbes & Infections

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

(2020) Ashleigh Shannon et al.   ANTIVIRAL RESEARCH

Antiviral activity of lycorine against Zika virus in vivo and in vitro

(2020) Huini Chen et al.   VIROLOGY

A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent RNA Polymerase Activity

(2020) Jung Sun Min et al.   Journal of Clinical Medicine

High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses

(2019) Liang Shen et al.   JOURNAL OF VIROLOGY

Molecular dynamics simulation of zika virus NS5 RNA dependent RNA polymerase with selected novel non-nucleoside inhibitors

(2019) Nasir Ahmad et al.   JOURNAL OF MOLECULAR STRUCTURE

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques

(2018) Giosuè Costa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Multiple biological functions and pharmacological effects of lycorine

(2013) ZhiFei Cao et al.   Science China-Chemistry

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

(2013) Deu John M. Cruz et al.   PLoS Neglected Tropical Diseases

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

(2011) Jiangning Liu et al.   Virology Journal

A cell-based reporter assay for inhibitor screening of hepatitis C virus RNA-dependent RNA polymerase

(2010) Jin-Ching Lee et al.   ANALYTICAL BIOCHEMISTRY

Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay

(2008) Y HWANG et al.   ANTIVIRAL RESEARCH