Multiple biological functions and pharmacological effects of lycorine

Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells

(2013) Ruifang Liu et al.   ANTI-CANCER DRUGS

Mechanisms of resistance to anti-angiogenesis therapies

(2013) Sandy Giuliano et al.   BIOCHIMIE

Ungeremine and Its Hemisynthesized Analogues as Bactericides against Flavobacterium columnare

(2013) Kevin K. Schrader et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity

(2013) Zhifei Cao et al.   TOXICOLOGY LETTERS

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

(2012) Ranlu Liu et al.   CANCER BIOLOGY & THERAPY

Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition

(2012) Lv Li et al.   Cancer Cell International

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Lycorine, a Candidate for the Control of Period Length in Mammalian Cells

(2012) Yoshiaki Onishi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anti-angiogenic drug discovery: lessons from the past and thoughts for the future

(2012) Jessie M Wu et al.   Expert Opinion on Drug Discovery

Bevacizumab: overview of the literature

(2012) Maria Ignez Braghiroli et al.   Expert Review of Anticancer Therapy

Simultaneous quantification of Amaryllidaceae alkaloids from Zephyranthes grandiflora by UPLC–DAD/ESI-MS/MS

(2012) Deepali Katoch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cancer prevention by targeting angiogenesis

(2012) Adriana Albini et al.   Nature Reviews Clinical Oncology

Antiangiogenic Therapy for Cancer: An Update

(2012) Belal Al-Husein et al.   PHARMACOTHERAPY

Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry

(2012) Ruifang Liu et al.   Pigment Cell & Melanoma Research

Progress on the total synthesis of natural products in China: From 2006 to 2010

(2012) Jie Chen et al.   Science China-Chemistry

Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity

(2012) Meimei Bao et al.   TOXICOLOGY LETTERS

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

(2012) Bingxue Shang et al.   Frontiers of Medicine

In vivo assessment of antiemetic drugs and mechanism of lycorine-induced nausea and emesis

(2011) Sascha Kretzing et al.   ARCHIVES OF TOXICOLOGY

Inhibitory Effects of Herbal Alkaloids on the Tumor Necrosis Factor-α and Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW264 Macrophages

(2011) Yoshimitsu Yamazaki et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Evaluation of analgesic, anti-inflammatory and hepatoprotective effects of lycorine from Sternbergia fisheriana (Herbert) Rupr.

(2011) G. Saltan Çitoğlu et al.   FITOTERAPIA

Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge

(2011) Jingjing Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation of narciprimine from Cyrtanthus contractus (Amaryllidaceae) and evaluation of its acetylcholinesterase inhibitory activity

(2011) Jerald J. Nair et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ascorbic acid and reactive oxygen species are involved in the inhibition of seed germination by abscisic acid in rice seeds

(2011) N. Ye et al.   JOURNAL OF EXPERIMENTAL BOTANY

Acetylcholinesterase-inhibiting Alkaloids from Zephyranthes concolor

(2011) Ricardo Reyes-Chilpa et al.   MOLECULES

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway

(2011) Raquel Brandt Giordani et al.   PHYTOCHEMISTRY

Copper-induced synthesis of ascorbate, glutathione and phytochelatins in the marine alga Ulva compressa (Chlorophyta)

(2011) Macarena Mellado et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

(2011) Jiangning Liu et al.   Virology Journal

Synthesis and antiplasmodial activity of lycorine derivatives

(2010) Juan C. Cedrón et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids

(2010) James McNulty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Up-regulation of p21 and TNF-alpha is mediated lycorine-induced death of HL-60 cells

(2010) Jing Liu et al.   Cancer Cell International

A Survey of Phytotoxic Microbial and Plant Metabolites as Potential Natural Products for Pest Management

(2010) Kevin K. Schrader et al.   CHEMISTRY & BIODIVERSITY

Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance

(2010) R. E. Hayden et al.   HAEMATOLOGICA

Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against Apoptosis-Resistant Cancer Cells†

(2010) Gwendoline Van Goietsenoven et al.   JOURNAL OF NATURAL PRODUCTS

Lycorine and its Derivatives for Anticancer Drug Design

(2010) D. Lamoral-Theys et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Trichomonas vaginalis nucleoside triphosphate diphosphohydrolase and ecto-5′-nucleotidase activities are inhibited by lycorine and candimine

(2010) Raquel B. Giordani et al.   PARASITOLOGY INTERNATIONAL

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Dose-dependent emetic effects of the Amaryllidaceous alkaloid lycorine in beagle dogs

(2010) Sascha Kretzing et al.   TOXICON

Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight

(2009) Delphine Lamoral-Theys et al.   JOURNAL OF MEDICINAL CHEMISTRY

LCMS and GCMS for the Screening of Alkaloids in Natural andin VitroExtracts ofLeucojum aestivum

(2009) Agata Ptak et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of (−)-Lycorine and (−)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade

(2009) Ken-ichi Yamada et al.   ORGANIC LETTERS

Rapid and Enantioselective Assembly of the Lycorine Framework Using Chemoenzymatic Techniques

(2009) Matthew T. Jones et al.   ORGANIC LETTERS

Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells

(2009) James McNulty et al.   PHYTOCHEMISTRY

Biological Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives: Discovery of Novel Leads for Anticancer Drug Design

(2009) Antonio Evidente et al.   PLANTA MEDICA

Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay

(2008) Y HWANG et al.   ANTIVIRAL RESEARCH

Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells

(2008) Xiao-shan Liu et al.   CANCER LETTERS

Two Novel Ceramides with a Phytosphingolipid and a Tertiary Amide Structure from Zephyranthes candida

(2008) Zhi-ping Wu et al.   LIPIDS

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

(2008) Gang Zou et al.   VIROLOGY