Acquired tick resistance: The trail is hot

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

(2020) Sukanya Narasimhan et al.   Ticks and Tick-Borne Diseases

Time-resolved proteomic profile of Amblyomma americanum tick saliva during feeding

(2020) Tae Kwon Kim et al.   PLoS Neglected Tropical Diseases

Emerging tick-borne pathogens of public health importance: a mini-review

(2020) Ilia Rochlin et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Interactions between Borrelia burgdorferi and ticks

(2020) Cheyne Kurokawa et al.   NATURE REVIEWS MICROBIOLOGY

Rhipicephalus microplus serpins interfere with host immune responses by specifically modulating mast cells and lymphocytes

(2020) Mariana L. Coutinho et al.   Ticks and Tick-Borne Diseases

Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities

(2020) Na Jia et al.   CELL

Expression and function assessment of two serpin-type serine protease inhibitors from Haemaphysalis doenitzi

(2020) Wenjing Du et al.   RESEARCH IN VETERINARY SCIENCE

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

(2019) Ryan O. M. Rego et al.   Parasites & Vectors

Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2

(2019) Stepan S. Denisov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunosuppressive functions of two novel tick serpins, HlSerpin‐a and HlSerpin‐b, from Haemaphysalis longicornis

(2019) Fanqi Wang et al.   IMMUNOLOGY

Cross protection induced by combined Subolesin-based DNA and protein immunizations against adult Haemaphysalis longicornis

(2019) Ibrahim A. Hassan et al.   VACCINE

Immunosuppressive effects of sialostatin L1 and L2 isolated from the taiga tick Ixodes persulcatus Schulze

(2019) Yamato Sajiki et al.   Ticks and Tick-Borne Diseases

The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding

(2019) Adrien A. Blisnick et al.   Vaccines

Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin

(2019) Daniela D. Moré et al.   BMC GENOMICS

An inhibitor of complement C5 provides structural insights into activation

(2019) Martin P. Reichhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tick-host-pathogen systems immunobiology an interactive trio

(2018) Stephen K Wikel   Frontiers in Bioscience-Landmark

The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields

(2018) Neia Naldaiz-Gastesi et al.   JOURNAL OF ANATOMY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization and expression analysis of a newly identified glutathione S-transferase of the hard tick Haemaphysalis longicornis during blood-feeding

(2018) Emmanuel Pacia Hernandez et al.   Parasites & Vectors

Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis

(2018) Teresa C. Assumpção et al.   Scientific Reports

Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice

(2018) Yuya Tabakawa et al.   Frontiers in Immunology

Interactomics and tick vaccine development: new directions for the control of tick-borne diseases

(2018) Sara Artigas-Jerónimo et al.   Expert Review of Proteomics

An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

(2018) Laura A. VanBlargan et al.   Cell Reports

Host-specific expression of Ixodes scapularis salivary genes

(2018) Sukanya Narasimhan et al.   Ticks and Tick-Borne Diseases

Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus

(2017) Alessandra Mara Franzin et al.   Parasites & Vectors

Expression and characterization of haemathrins, madanin-like thrombin inhibitors, isolated from the salivary gland of tick Haemaphysalis bispinosa (Acari: Ixodidae)

(2017) Rajeev Kungur Brahma et al.   THROMBOSIS RESEARCH

Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity

(2017) John J. Suschak et al.   Human Vaccines & Immunotherapeutics

Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

(2017) Ala E. Tabor et al.   Frontiers in Cellular and Infection Microbiology

Bovine Immune Factors Underlying Tick Resistance: Integration and Future Directions

(2017) Luïse Robbertse et al.   Frontiers in Cellular and Infection Microbiology

Tick-Host Range Adaptation: Changes in Protein Profiles in Unfed Adult Ixodes scapularis and Amblyomma americanum Saliva Stimulated to Feed on Different Hosts

(2017) Lucas Tirloni et al.   Frontiers in Cellular and Infection Microbiology

Ticks, Ixodes scapularis, Feed Repeatedly on White-Footed Mice despite Strong Inflammatory Response: An Expanding Paradigm for Understanding Tick–Host Interactions

(2017) Jennifer M. Anderson et al.   Frontiers in Immunology

Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites

(2017) Takuya Ohta et al.   Frontiers in Immunology

The putative role of Rhipicephalus microplus salivary serpins in the tick-host relationship

(2016) Lucas Tirloni et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Anti-complement activity of the Ixodes scapularis salivary protein Salp20

(2016) Dennis E. Hourcade et al.   MOLECULAR IMMUNOLOGY

Need for a New Lyme Disease Vaccine

(2016) Stanley A. Plotkin   NEW ENGLAND JOURNAL OF MEDICINE

2-Cys peroxiredoxin is required in successful blood-feeding, reproduction, and antioxidant response in the hard tick Haemaphysalis longicornis

(2016) Kodai Kusakisako et al.   Parasites & Vectors

Enolase, a plasminogen receptor isolated from salivary gland transcriptome of the ixodid tick Haemaphysalis flava

(2016) Xing-Li Xu et al.   PARASITOLOGY RESEARCH

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick–Host Interactions

(2016) Jindřich Chmelař et al.   TRENDS IN PARASITOLOGY

AnIxodes ricinusTick Salivary Lectin Pathway Inhibitor ProtectsBorrelia burgdorferisensu lato from Human Complement

(2016) Alex Wagemakers et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Structural characterization of tick cement cones collected from in vivo and artificial membrane blood-fed Lone Star ticks ( Amblyomma americanum )

(2016) Rebekah Bullard et al.   Ticks and Tick-Borne Diseases

Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze

(2016) Kochi Toyomane et al.   Ticks and Tick-Borne Diseases

Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the yeast Pichia pastoris

(2016) Tao Xu et al.   Ticks and Tick-Borne Diseases

Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection

(2016) James J. Valdés et al.   Scientific Reports

Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding

(2016) Tae Kwon Kim et al.   PLoS Neglected Tropical Diseases

An Ixodes scapularis cell line with a predominantly neuron-like phenotype

(2015) Jonathan D. Oliver et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Ixodes ricinus Salivary Serpin IRS-2 Affects Th17 Differentiation via Inhibition of the Interleukin-6/STAT-3 Signaling Pathway

(2015) Jana Páleníková et al.   INFECTION AND IMMUNITY

Successful Feeding of Amblyomma coelebs (Acari: Ixodidae) Nymphs on Humans in Brazil: Skin Reactions to Parasitism

(2015) M. V. Garcia et al.   JOURNAL OF MEDICAL ENTOMOLOGY

Modulation of host immunity by tick saliva

(2015) Jan Kotál et al.   Journal of Proteomics

Tick Saliva Enhances Powassan Virus Transmission to the Host, Influencing Its Dissemination and the Course of Disease

(2015) Meghan E. Hermance et al.   JOURNAL OF VIROLOGY

The immunology of the porcine skin and its value as a model for human skin

(2015) Artur Summerfield et al.   MOLECULAR IMMUNOLOGY

Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes

(2015) Jaroslava Lieskovská et al.   Parasites & Vectors

Climate change and vector-borne diseases: what are the implications for public health research and policy?

(2015) D. Campbell-Lendrum et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Longistatin in tick-saliva targets RAGE

(2015) Anisuzzaman et al.   Oncotarget

Deep Sequencing Analysis of the Ixodes ricinus Haemocytome

(2015) Michalis Kotsyfakis et al.   PLoS Neglected Tropical Diseases

Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management

(2015) Petra Bogovic   World Journal of Clinical Cases

CHARACTERIZATION OF A NEW KUNITZ-TYPE SERINE PROTEASE INHIBITOR FROM THE HARD TICKRhipicephalus hemaphysaloides

(2015) Jie Cao et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

An Insight into the Sialome of the Lone Star Tick, Amblyomma americanum, with a Glimpse on Its Time Dependent Gene Expression

(2015) Shahid Karim et al.   PLoS One

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance

(2014) V. Flacher et al.   EMBO Molecular Medicine

A blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting

(2014) Adriana M.G. Ibelli et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A Novel Mechanism of Complement Inhibition Unmasked by a Tick Salivary Protein That Binds to Properdin

(2014) K. R. Tyson et al.   JOURNAL OF IMMUNOLOGY

Effects of environmental change on zoonotic disease risk: an ecological primer

(2014) Agustín Estrada-Peña et al.   TRENDS IN PARASITOLOGY

Factor Xa Activation of Factor V Is of Paramount Importance in Initiating the Coagulation System

(2013) Tim J. Schuijt et al.   CIRCULATION

Emerging Role of Human Basophil Biology in Health and Disease

(2013) Jessica L. Cromheecke et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Prostaglandin E2 in tick saliva regulates macrophage cell migration and cytokine profile

(2013) Nina M Poole et al.   Parasites & Vectors

The Tick-Derived Anticoagulant Madanin Is Processed by Thrombin and Factor Xa

(2013) Ana C. Figueiredo et al.   PLoS One

How ticks get under your skin: insertion mechanics of the feeding apparatus of Ixodes ricinus ticks

(2013) D. Richter et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Purification of a serine protease and evidence for a protein C activator from the saliva of the tick, Ixodes scapularis

(2013) Sivakamasundari Pichu et al.   TOXICON

Novel Immunomodulators from Hard Ticks Selectively Reprogramme Human Dendritic Cell Responses

(2013) Stephen G. Preston et al.   PLoS Pathogens

Vaccination against Lyme disease: past, present, and future

(2013) Monica E. Embers et al.   Frontiers in Cellular and Infection Microbiology

Harnessing the skin-thyroid connection for wound healing: a prospective controlled trial in guinea pigs

(2012) R. Kassem et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

The quest for a universal vaccine against ticks: Cross-immunity insights

(2012) Luís F. Parizi et al.   VETERINARY JOURNAL

Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis

(2012) A.J. Ullmann et al.   Ticks and Tick-Borne Diseases

A Tick Mannose-Binding Lectin Inhibitor Interferes with the Vertebrate Complement Cascade to Enhance Transmission of the Lyme Disease Agent

(2011) Tim J. Schuijt et al.   Cell Host & Microbe

Susceptibility of different populations of ticks to entomopathogenic fungi

(2011) W.M.S. Perinotto et al.   EXPERIMENTAL PARASITOLOGY

Identification and Characterization of Ixodes scapularis Antigens That Elicit Tick Immunity Using Yeast Surface Display

(2011) Tim J. Schuijt et al.   PLoS One

Molecular genetic approaches for identifying the basis of variation in resistance to tick infestation in cattle

(2011) Laercio R. Porto Neto et al.   VETERINARY PARASITOLOGY

Longistatin, a Plasminogen Activator, Is Key to the Availability of Blood-Meals for Ixodid Ticks

(2011) Anisuzzaman et al.   PLoS Pathogens

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

(2010) J. Chmelar et al.   BLOOD

Role of basophils in the initiation of Th2 responses

(2010) Caroline L Sokol et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular identification and expression analysis of lipocalins from blood feeding taiga tick, Ixodes persulcatus Schulze

(2010) Satoru Konnai et al.   EXPERIMENTAL PARASITOLOGY

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

(2010) Takeshi Wada et al.   JOURNAL OF CLINICAL INVESTIGATION

The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model

(2010) Michalis Kotsyfakis et al.   MOLECULAR MICROBIOLOGY

Basophils induce Th2 immunity

(2010) Booki Min   Virulence

Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis

(2009) Albert Mulenga et al.   BMC GENOMICS

Vaccines: the Fourth Century

(2009) S. A. Plotkin   Clinical and Vaccine Immunology

Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tickIxodes ricinus

(2009) Pierre-Paul Prevot et al.   FEBS Journal

Tick genomics - coming of age

(2009) Vishvanath Nene   Frontiers in Bioscience-Landmark

Tick-borne pathogens, transmission rates and climate change

(2009) Agustin Estrada-Pena   Frontiers in Bioscience-Landmark

The role of saliva in tick feeding

(2009) Ivo et al.   Frontiers in Bioscience-Landmark

Functional role of 64P, the candidate transmission-blocking vaccine antigen from the tick, Rhipicephalus appendiculatus

(2009) Sabína Havlíková et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Ir-CPI, a coagulation contact phase inhibitor from the tickIxodes ricinus, inhibits thrombus formation without impairing hemostasis

(2009) Yves Decrem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel sphingomyelinase-like enzyme inIxodes scapularistick saliva drives host CD4+T cells to express IL-4

(2009) F.J. ALARCON-CHAIDEZ et al.   PARASITE IMMUNOLOGY

The balance between immunity and tolerance: The role of Langerhans cells

(2008) K. Mutyambizi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus

(2008) Yves Decrem et al.   FEBS Journal

Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein ofHaemaphysalis longicornis

(2008) Satoru Konnai et al.   IMMUNOLOGY

Biology of Ticks

(2008) John F. Anderson et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Transgene expression and silencing in a tick cell line: A model system for functional tick genomics

(2008) Timothy J. Kurtti et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ticks produce highly selective chemokine binding proteins with antiinflammatory activity

(2008) Maud Déruaz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ir-LBP, an Ixodes ricinus Tick Salivary LTB4-Binding Lipocalin, Interferes with Host Neutrophil Function

(2008) Jérôme Beaufays et al.   PLoS One

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

(2008) Joppe W. R. Hovius et al.   PLoS Pathogens

The impact of gene knock-down and vaccination against salivary metalloproteases on blood feeding and egg laying by Ixodes ricinus

(2007) Yves Decrem et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY