Article
Biochemistry & Molecular Biology
Xiaoyan Li, Zhengming Wu, Jing He, Yiting Jin, Chengyu Chu, Yun Cao, Fei Gu, Hongying Wang, Chenjian Hou, Xiuping Liu, Qiang Zou
Summary: The incidence of thyroid cancer is increasing globally, with poor prognosis associated with distant metastases. OGT and YAP play critical roles in papillary thyroid cancer, suggesting potential for targeted therapies.
Review
Medicine, Research & Experimental
Wenhao Mao, Jia Mai, Hui Peng, Junhu Wan, Ting Sun
Summary: This review explores the oncogenic role and regulatory mechanism of YAP in PDAC, highlighting its potential as a therapeutic target in various human cancers.
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Review
Medicine, Research & Experimental
Javeria Qadir, Feiya Li, Burton B. Yang
Summary: This review examines the interplay between the Hippo signaling pathway and circular RNAs (circRNAs) in various forms of cancer. It discusses how circRNAs can function as either tumor suppressors or oncogenes in cancer by interacting with miRNAs or proteins. The review also highlights the limitations and constraints in studying circRNA mechanisms, and raises questions about the role of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, it explores the potential of circRNAs as diagnostic and prognostic biomarkers, as well as molecular targets for cancer therapy.
Article
Oncology
Tianxing Zhou, Xueyang Li, Jing Liu, Jihui Hao
Summary: Despite improvements in cancer survival, the mechanisms of cancer metastasis remain poorly understood. Metastasis involves a series of events such as epithelial-to-mesenchymal transition, invasion, angiogenesis, intravasation, survival in circulation, extravasation, mesenchymal-to-epithelial transition, colonization, and adaptation. Furthermore, cancer cells can remodel the tumor microenvironment and evade immune surveillance. The Hippo signaling pathway has been identified as a key regulator of cancer metastasis, offering potential as a therapeutic target.
CANCER BIOLOGY & MEDICINE
(2023)
Review
Oncology
Enrique Rozengurt, Guido Eibl
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, and recent literature on the complex crosstalk between KRAS, YAP, and Src tyrosine kinase family (SFK) in PDAC development and maintenance highlights new mechanistic and translational advances. Studies have shown the importance of RAS dimerization in signal transduction and how certain SFK members can phosphorylate and inhibit RAS function, suggesting a less crucial role for RAS in certain subtypes of PDAC. This points to the potential of targeting SFK to combat drug resistance and aggressive features in PDAC treatment.
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Oncology
Verena Hoffken, Anke Hermann, Hermann Pavenstadt, Joachim Kremerskothen
Summary: The conserved Hippo pathway plays a crucial role in regulating cell proliferation and apoptosis through various mechanisms, essential for organ size control and tumor prevention. WWC proteins, as components and upstream regulators of the Hippo pathway, are often overlooked in their role in cancer development.
Correction
Biochemistry & Molecular Biology
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang
Summary: The paper has published an amendment which can be accessed through the original article.
Review
Cell Biology
Priyanka Samji, Manoj K. Rajendran, Vidya P. Warrier, Akshayaa Ganesh, Karunagaran Devarajan
Summary: Recent studies have shown that dysregulation of Hippo signaling, particularly the hyper activation of YAP/TAZ, can lead to uncontrolled cell proliferation and malignancy. Additionally, Hippo pathway may play a role in mediating chemotherapeutic resistance in cancer cells.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng
Summary: YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Jing Cai, Kyungsuk Choi, Hongde Li, Katiuska Daniela Pulgar Prieto, Yonggang Zheng, Duojia Pan
Summary: This study reveals that the essential role of YAP in liver and lung development can be bypassed by inactivation of the TEAD corepressor VGLL4, indicating that YAP's major physiological function is to antagonize VGLL4. The findings highlight the central importance of VGLL4-mediated transcriptional repression in regulating the Hippo pathway and provide insights into potential strategies for modulating Hippo signaling in cancer and regenerative medicine.
GENES & DEVELOPMENT
(2022)
Article
Cell Biology
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Summary: This study reveals the crucial role of YAP in breast cancer stem cells. Knockdown of YAP reduces the viability and stemness of BCSCs in vitro and tumor formation in vivo. IGF-1R and IGF-1 regulate the expression and localization of YAP, and YAP overexpression increases the expression of IGF-1. Clinical analysis shows that high levels of YAP and IGF-1 are associated with shorter overall survival in basal-like breast cancer patients. In conclusion, the interplay between YAP and the IGF-1/IGF-1R pathway is clinically relevant for sustaining the properties of BCSCs.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biology
Rachel Warren, Handeng Lyu, Kylie Klinkhammer, Stijn P. De Langhe
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by fibrotic alveolar remodeling and progressive loss of pulmonary function. Chronic alveolar injury and failure to repair the respiratory epithelium are intrinsic to IPF pathogenesis. Loss or dysfunction of alveolar type 2 (AT2) stem cells can trigger pulmonary fibrosis. Increased YAP activity in respiratory epithelial cells in IPF lungs may promote pulmonary fibrosis. However, recent research also shows that YAP and Taz are important for AT1 cell maintenance and alveolar epithelial regeneration. Targeting YAP may help promote AT1 cell regeneration and treat pulmonary fibrosis.
Article
Immunology
Tao Li, Whayoung Lee, Hidetaka Hara, Cassandra Long, Mohamed Ezzelarab, David Ayares, Hai Huang, Yi Wang, Charles T. Esmon, David K. C. Cooper, Hayato Iwase
Article
Medicine, Research & Experimental
Hayato Iwase, Hong Liu, Tao Li, Zhongquiang Zhang, Bingsi Gao, Hidetaka Hara, Martin Wijkstrom, Cassandra Long, Ryan Saari, David Ayares, David K. C. Cooper, Mohamed B. Ezzelarab
XENOTRANSPLANTATION
(2017)
Article
Medicine, Research & Experimental
Hayato Iwase, Hidetaka Hara, Mohamed Ezzelarab, Tao Li, Zhongqiang Zhang, Bingsi Gao, Hong Liu, Cassandra Long, Yi Wang, Amy Cassano, Edwin Klein, Carol Phelps, David Ayares, Abhinav Humar, Martin Wijkstrom, David K. C. Cooper
XENOTRANSPLANTATION
(2017)
Review
Medicine, Research & Experimental
Tao Li, Hongtao Jiang, Houqin Liu, David K. C. Cooper, Yi Wang
XENOTRANSPLANTATION
(2020)
Article
Immunology
Tao Li, Hao Feng, Jiaxiang Du, Qiangbing Xia, David K. C. Cooper, Hongtao Jiang, Songzhe He, Dengke Pan, Gang Chen, Yi Wang
Summary: This study investigated some issues to be considered before kidney xenotransplantation. The results suggest that CMAHKO in pigs may be critical to the success of clinical pig kidney xenotransplantation, and TKO pigs with certain human genes may prove to be optimal kidney sources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hao Feng, Tao Li, Jiaxiang Du, Qiangbing Xia, Lu Wang, Song Chen, Lan Zhu, Dengke Pan, Yi Wang, Gang Chen
Summary: This study reveals the significance of Sda in pig-to-rhesus monkey xenotransplantation, highlighting the role of natural and induced anti-Sda antibodies in the immune response during transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Songzhe He, Tao Li, Hao Feng, Jiaxiang Du, David K. C. Cooper, Hidetaka Hara, Hongtao Jiang, Dengke Pan, Gang Chen, Yi Wang
Summary: This study investigated the occurrence of antibodies to unknown pig xenoantigens in different human groups. The results showed the presence of IgM antibodies against TKO/hCD55 pig peripheral blood mononuclear cells (PBMCs) in healthy individuals, patients with end-stage renal disease (ESRD), and renal transplant recipients. These antibodies may be reacting to swine leukocyte antigens.
XENOTRANSPLANTATION
(2023)
Article
Immunology
Tao Li, Hidetaka Hara, Mohamed B. Ezzelarab, Cassandra Long, Yongqi Long, Yi Wang, David K. C. Cooper, Hayato Iwase
EUROPEAN JOURNAL OF INFLAMMATION
(2018)