The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

(2019) Yuxiang Wang et al.   Nature Communications

Whole genome experimental maps of DNA G-quadruplexes in multiple species

(2019) Giovanni Marsico et al.   NUCLEIC ACIDS RESEARCH

The diverse structural landscape of quadruplexes

(2019) Helen L. Lightfoot et al.   FEBS LETTERS

The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands

(2019) Recagni et al.   Cells

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

(2018) Robert Hänsel-Hertsch et al.   Nature Protocols

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide

(2018) Martina Tassinari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells

(2018) Lukasz Skalniak et al.   Cancers

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

(2017) Gemma Macchia et al.   GENETICS

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

(2017) Veronica Tisato et al.   Journal of Hematology & Oncology

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

(2017) Joshua R. Porter et al.   MOLECULAR CELL

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

(2017) Oliver G McDonald et al.   NATURE GENETICS

The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes

(2017) Matteo Scalabrin et al.   Scientific Reports

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

(2017) Gemma Macchia et al.   GENETICS

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide‐repeat protein deposition

(2016) Kohji Mori et al.   EMBO REPORTS

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

(2016) Carika Weldon et al.   Nature Chemical Biology

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

G-register exchange dynamics in guanine quadruplexes

(2016) Robert W. Harkness et al.   NUCLEIC ACIDS RESEARCH

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions

(2015) Yonglun Luo et al.   BMC GENOMICS

RG7112, a Small-Molecule Inhibitor of MDM2, Enhances Trabectedin Response in Soft Tissue Sarcomas

(2015) Antònia Obrador-Hevia et al.   CANCER INVESTIGATION

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

(2015) Roberto Simone et al.   FEBS LETTERS

Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

(2015) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription

(2015) Elena Tosoni et al.   NUCLEIC ACIDS RESEARCH

Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution

(2015) Jasna Brčić et al.   NUCLEIC ACIDS RESEARCH

Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD

(2015) Bo Zhou et al.   Scientific Reports

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?

(2015) Aaron M. Fleming et al.   ACS Central Science

The regulation of MDM2 oncogene and its impact on human cancers

(2014) Y. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

(2014) Silvia Da Ros et al.   PLoS One

The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification

(2013) Christopher D M Fletcher   HISTOPATHOLOGY

Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

(2012) Q. Li et al.   CLINICAL CANCER RESEARCH

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

(2012) Isabelle Ray-Coquard et al.   LANCET ONCOLOGY

Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival

(2011) A. Italiano et al.   ANNALS OF ONCOLOGY

Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein

(2011) Kentaro Takahama et al.   FEBS Journal

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

(2010) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

(2010) Steven A. Roberts et al.   NATURE

Repeat instability as the basis for human diseases and as a potential target for therapy

(2010) Arturo López Castel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

(2009) Martin Enge et al.   CANCER CELL

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA

(2008) T. R. Salas et al.   NUCLEIC ACIDS RESEARCH

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

(2008) D. Weidensdorfer et al.   RNA