Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives

Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells

(2020) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

(2020) Josué Carvalho et al.   TRENDS IN MOLECULAR MEDICINE

uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells

(2020) Annalisa Pecoraro et al.   Biomolecules

Thrombin Generation and Cancer: Contributors and Consequences

(2019) Caroline Reddel et al.   Cancers

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation

(2019) Junyan Wang et al.   ACS Chemical Biology

Therapeutic applications of AS1411 aptamer, an update review

(2019) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives

(2019) Carolina Roxo et al.   MOLECULES

Ribosomal protein uL3 targets E2F1 and Cyclin D1 in cancer cell response to nucleolar stress

(2019) Annalisa Pecoraro et al.   Scientific Reports

Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance

(2019) Manojkumar Varada et al.   ACS Omega

The “Janus face” of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications

(2018) Veronica Esposito et al.   BIOORGANIC CHEMISTRY

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

(2018) Weronika Kotkowiak et al.   Molecular Therapy-Nucleic Acids

Thrombin binding aptamer analogues containing inversion of polarity sites endowed with antiproliferative and anti-motility properties against Calu-6 cells

(2018) Veronica Esposito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells

(2017) Annapina Russo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

(2016) Annapina Russo et al.   Oncotarget

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

(2015) Axel Vater et al.   DRUG DISCOVERY TODAY

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

(2015) Maria Scuotto et al.   NUCLEIC ACIDS RESEARCH

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

(2015) Antonella Virgilio et al.   NUCLEIC ACIDS RESEARCH

Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

(2015) Nan Zhang et al.   Chemical Science

Thrombin promotes proliferation of human lung fibroblasts via protease activated receptor-1-dependent and NF-κB-independent pathways

(2014) Shengyu Zhou et al.   CELL BIOLOGY INTERNATIONAL

Expanding the Potential of G-Quadruplex Structures: Formation of a Heterochiral TBA Analogue

(2014) Antonella Virgilio et al.   CHEMBIOCHEM

5-Hydroxymethyl-2′-Deoxyuridine Residues in the Thrombin Binding Aptamer: Investigating Anticoagulant Activity by Making a Tiny Chemical Modification

(2014) Antonella Virgilio et al.   CHEMBIOCHEM

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation

(2014) Daniele De Filippis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

(2014) Veronica Esposito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

(2012) Anna Avino et al.   CURRENT PHARMACEUTICAL DESIGN

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

(2012) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5

(2008) D De Filippis et al.   BRITISH JOURNAL OF PHARMACOLOGY