G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives

Comparison of turn-on and ratiometric fluorescent G-quadruplex aptasensor approaches for the detection of ATP

(2019) Sathya Srinivasan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

An Electrochemical Aptamer-Based Sensor for Real-Time Monitoring of Insulin

(2019) Yao Wu et al.   ACS Sensors

Aptamer-Conjugated Au Nanocage/SiO2 Core–Shell Bifunctional Nanoprobes with High Stability and Biocompatibility for Cellular SERS Imaging and Near-Infrared Photothermal Therapy

(2019) Shengping Wen et al.   ACS Sensors

Comparison of Effects of Anti-thrombin Aptamers HD1 and HD22 on Aggregation of Human Platelets, Thrombin Generation, Fibrin Formation, and Thrombus Formation Under Flow Conditions

(2019) Katarzyna Derszniak et al.   Frontiers in Pharmacology

Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy

(2019) Brandon Wilbanks et al.   Nucleic Acid Therapeutics

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

(2019) Weronika Kotkowiak et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-rich VEGF Aptamer as a Potential Inhibitor of Chitin Trafficking Signal in Emerging Opportunistic Yeast Infection

(2019) Mohammad Vahed et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

High affinity of AS1411 toward copper; its application in a sensitive aptasensor for copper detection

(2019) Amirhossein Bahreyni et al.   ANALYTICAL BIOCHEMISTRY

The role of G-quadruplex structures of LIGS-generated aptamers R1.2 and R1.3 in IgM specific recognition

(2019) Federica Moccia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells

(2019) Josué Carvalho et al.   Scientific Reports

Investigating the properties of TBA variants with twin thrombin binding domains

(2019) Teresa Amato et al.   Scientific Reports

Complex formation with protamine prolongs the thrombin-inhibiting effect of DNA aptamer in vivo

(2018) V.A. Spiridonova et al.   BIOCHIMIE

The “Janus face” of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications

(2018) Veronica Esposito et al.   BIOORGANIC CHEMISTRY

A genome-inspired, reverse selection approach to aptamer discovery

(2018) Christina M. Albanese et al.   TALANTA

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

(2018) Weronika Kotkowiak et al.   Molecular Therapy-Nucleic Acids

Gemcitabine-incorporated G-quadruplex aptamer for targeted drug delivery into pancreas cancer

(2018) Jun Young Park et al.   Molecular Therapy-Nucleic Acids

Thrombin binding aptamer analogues containing inversion of polarity sites endowed with antiproliferative and anti-motility properties against Calu-6 cells

(2018) Veronica Esposito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells

(2018) Priya Kalra et al.   Molecular Therapy-Nucleic Acids

AS1411 aptamer-targeted gold nanoclusters effect on the enhancement of radiation therapy efficacy in breast tumor-bearing mice

(2018) Fatemeh Ghahremani et al.   Nanomedicine

Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer

(2018) Romualdo Troisi et al.   NUCLEIC ACIDS RESEARCH

A novel fluorometric method for inorganic pyrophosphatase detection based on G-quadruplex-thioflavin T

(2018) Han Zhao et al.   MOLECULAR AND CELLULAR PROBES

G-quadruplex structure of an anti-proliferative DNA sequence

(2017) Ngoc Quang Do et al.   NUCLEIC ACIDS RESEARCH

A novel, highly sensitive, selective, reversible and turn-on chemi-sensor based on Schiff base for rapid detection of Cu(II)

(2017) Sayed M. Saleh et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Triplex-quadruplex structural scaffold: a new binding structure of aptamer

(2017) Tao Bing et al.   Scientific Reports

The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36

(2017) Elena Zavyalova et al.   Frontiers in Pharmacology

Three different signal amplification strategies for the impedimetric sandwich detection of thrombin

(2016) Cristina Ocaña et al.   ANALYTICA CHIMICA ACTA

Investigation of the selectivity of thrombin-binding aptamers for thrombin titration in murine plasma

(2016) Ana Trapaidze et al.   BIOSENSORS & BIOELECTRONICS

A label-free electrochemical aptasensor based on graphene oxide/double-stranded DNA nanocomposite

(2016) Yu Li et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell

(2016) Rosalba Perrone et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cation Coordination Alters the Conformation of a Thrombin-Binding G-Quadruplex DNA Aptamer That Affects Inhibition of Thrombin

(2016) Elena Zavyalova et al.   Nucleic Acid Therapeutics

AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin

(2016) Ye Cheng et al.   PLoS One

Label-free aptamer biosensor for selective detection of thrombin

(2015) Weidan Na et al.   ANALYTICA CHIMICA ACTA

Modulation of the Coagulation Cascade Using AptamersSignificance

(2015) Rebecca S. Woodruff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1

(2015) Mathieu Métifiot et al.   BIOCHIMIE

Construction of photoelectrochemical thrombin aptasensor via assembling multilayer of graphene–CdS nanocomposites

(2015) Li Shangguan et al.   BIOSENSORS & BIOELECTRONICS

Study of the Function of G-Rich Aptamers Selected for Lung Adenocarcinoma

(2015) Jun Hu et al.   Chemistry-An Asian Journal

Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer

(2015) Erin R. Gaddes et al.   EXPERIMENTAL CELL RESEARCH

A family of DNA aptamers with varied duplex region length that forms complexes with thrombin and prothrombin

(2015) V.A. Spiridonova et al.   FEBS LETTERS

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

(2015) E. Merit Reyes-Reyes et al.   Molecular Oncology

A multifunctional hemin@metal–organic framework and its application to construct an electrochemical aptasensor for thrombin detection

(2015) Shunbi Xie et al.   Nanoscale

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

(2015) Maria Scuotto et al.   NUCLEIC ACIDS RESEARCH

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

(2015) Antonella Virgilio et al.   NUCLEIC ACIDS RESEARCH

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding

(2015) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy

(2015) Xu Wu et al.   Theranostics

5-Hydroxymethyl-2′-Deoxyuridine Residues in the Thrombin Binding Aptamer: Investigating Anticoagulant Activity by Making a Tiny Chemical Modification

(2014) Antonella Virgilio et al.   CHEMBIOCHEM

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance

(2014) Veronica Esposito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stability and bioactivity of thrombin binding aptamers modified with d-/l-isothymidine in the loop regions

(2014) Baobin Cai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evaluation of Antithrombotic Activity of Thrombin DNA Aptamers by a Murine Thrombosis Model

(2014) Elena Zavyalova et al.   PLoS One

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

A highly sensitive electrochemical aptasensor for thrombin detection using functionalized mesoporous silica@multiwalled carbon nanotubes as signal tags and DNAzyme signal amplification

(2013) Juan Zhang et al.   ANALYST

Development of a label-free aptasensor for monitoring the self-association of lysozyme

(2013) Alina Vasilescu et al.   ANALYST

Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism

(2013) Hye-Min Woo et al.   ANTIVIRAL RESEARCH

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer

(2013) Andrea Pica et al.   FEBS Journal

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

(2013) Maja Marušič et al.   NUCLEIC ACIDS RESEARCH

General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure

(2013) Tianjun Chang et al.   PLoS One

A Short DNA Aptamer That Recognizes TNFα and Blocks Its Activity in Vitro

(2012) Erik W. Orava et al.   ACS Chemical Biology

Affinity Improvement of a VEGF Aptamer by in Silico Maturation for a Sensitive VEGF-Detection System

(2012) Yoshihiko Nonaka et al.   ANALYTICAL CHEMISTRY

In situ enzymatic silver enhancement based on functionalized graphene oxide and layer-by-layer assembled gold nanoparticles for ultrasensitive detection of thrombin

(2012) Yan Wang et al.   BIOSENSORS & BIOELECTRONICS

Translational Success Stories

(2012) Michiel Coppens et al.   CIRCULATION RESEARCH

DNA Aptamers for Human Thrombin with High Anticoagulant Activity Demonstrate Target- and Species-Specificity

(2012) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

(2012) Anna Avino et al.   CURRENT PHARMACEUTICAL DESIGN

G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application

(2012) W. O. Tucker et al.   CURRENT PHARMACEUTICAL DESIGN

Investigating the Role of T7 and T12 Residues on the Biological Properties of Thrombin-Binding Aptamer: Enhancement of Anticoagulant Activity by a Single Nucleobase Modification

(2012) Nicola Borbone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-prion activity of an RNA aptamer and its structural basis

(2012) Tsukasa Mashima et al.   NUCLEIC ACIDS RESEARCH

Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis

(2012) John Smestad et al.   NUCLEIC ACIDS RESEARCH

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

(2012) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

d(GGGT)4and r(GGGU)4are both HIV-1 inhibitors and interleukin-6 receptor aptamers

(2012) Eileen Magbanua et al.   RNA Biology

The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration

(2011) Aurélie Faure-Perraud et al.   ANTIVIRAL THERAPY

Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling

(2011) Ka To Shum et al.   BIOCHEMICAL JOURNAL

Aptamer-Mediated Inhibition ofMycobacterium tuberculosisPolyphosphate Kinase 2

(2011) Ka To Shum et al.   BIOCHEMISTRY

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2′-C-piperazino-UNA monomer

(2011) Troels B. Jensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characteristics of a New DNA Aptamer, Direct Inhibitor of Thrombin

(2011) A. V. Mazurov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

A G-Quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2 in vitro

(2011) Jia Hu et al.   CHEMBIOCHEM

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

Novel Modular DNA Aptamer for Human Thrombin with High Anticoagulant Activity

(2011) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons

(2011) X. Ni et al.   CURRENT MEDICINAL CHEMISTRY

Aptamer-based modulation of blood coagulation

(2011) G. Mayer et al.   Hamostaseologie

Functional binding of hexanucleotides to 3C protease of hepatitis A virus

(2011) Bärbel S. Blaum et al.   NUCLEIC ACIDS RESEARCH

HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges

(2011) Vineeth Thachappilly Mukundan et al.   NUCLEIC ACIDS RESEARCH

The GP120 Molecule of HIV-1 and its Interaction with T Cells

(2010) V. Yoon et al.   CURRENT MEDICINAL CHEMISTRY

Direct detection of aptamer-thrombin binding via surface-enhanced Raman spectroscopy

(2010) Cynthia V. Pagba et al.   JOURNAL OF BIOMEDICAL OPTICS

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence

(2010) Magdalena M. Dailey et al.   NUCLEIC ACIDS RESEARCH

Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids

(2010) Erik B. Pedersen et al.   NUCLEIC ACIDS RESEARCH

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

(2010) M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Fluorescent Peptide for the Detection of Vascular Endothelial Growth Factor (VEGF)

(2009) Yoshio Suzuki et al.   CHEMBIOCHEM

Nucleic Acid Aptamers Based on the G-Quadruplex Structure: Therapeutic and Diagnostic Potential

(2009) B. Gatto et al.   CURRENT MEDICINAL CHEMISTRY

Combinatorial Synthesis of Thrombin-Binding Aptamers Containing iso-Guanine

(2009) Subba Rao Nallagatla et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

A Nucleolin-Targeted Multimodal Nanoparticle Imaging Probe for Tracking Cancer Cells Using an Aptamer

(2009) D. W. Hwang et al.   JOURNAL OF NUCLEAR MEDICINE

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

(2009) S. Soundararajan et al.   MOLECULAR PHARMACOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Development of universal antidotes to control aptamer activity

(2009) Sabah Oney et al.   NATURE MEDICINE

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

(2009) T. Mashima et al.   NUCLEIC ACIDS RESEARCH

Selection of DNA aptamers against insulin and construction of an aptameric enzyme subunit for insulin sensing

(2008) Wataru Yoshida et al.   BIOSENSORS & BIOELECTRONICS

Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase

(2008) J. MÜLLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

4-Thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix

(2008) S. MENDELBOUM RAVIV et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases

(2008) D. Michalowski et al.   NUCLEIC ACIDS RESEARCH

Stability and Binding Properties of a Modified Thrombin Binding Aptamer

(2007) Bruno Pagano et al.   BIOPHYSICAL JOURNAL