Tubulin polyglutamylation, a regulator of microtubule functions, can cause neurodegeneration

A Combinatorial MAP Code Dictates Polarized Microtubule Transport

(2020) Brigette Y. Monroy et al.   DEVELOPMENTAL CELL

Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

(2020) Satish Bodakuntla et al.   JOURNAL OF CELL SCIENCE

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tubulin Code in Microtubule Dynamics and Information Encoding

(2020) Antonina Roll-Mecak   DEVELOPMENTAL CELL

HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions

(2020) Alexis Osseni et al.   JOURNAL OF CELL BIOLOGY

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

(2020) Kishore K. Mahalingan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

(2020) André T. Lopes et al.   PLOS BIOLOGY

Nna1 gene deficiency triggers Purkinje neuron death by tubulin hyperglutamylation and ER dysfunction

(2020) Jianxue Li et al.   JCI Insight

Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia

(2019) Zafar Iqbal et al.   GENETICS IN MEDICINE

Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules

(2019) Sang Chul Shin et al.   Cell Reports

MAP7 family proteins regulate kinesin-1 recruitment and activation

(2019) Peter Jan Hooikaas et al.   JOURNAL OF CELL BIOLOGY

Polyglutamylation of tubulin’s C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

(2019) Dominique V Lessard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biallelic variants in AGTPBP1, involved in tubulin deglutamylation, are associated with cerebellar degeneration and motor neuropathy

(2019) Ruth Sheffer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Functions of Microtubule Disassembly during Neurite Pruning

(2019) Sebastian Rumpf et al.   TRENDS IN CELL BIOLOGY

ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation

(2019) Lin Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice

(2019) Alistair T Pagnamenta et al.   HUMAN MOLECULAR GENETICS

Microtubule control of functional architecture in neurons

(2019) Michael T Kelliher et al.   CURRENT OPINION IN NEUROBIOLOGY

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

(2019) Valerie Siahaan et al.   NATURE CELL BIOLOGY

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport

(2019) Mithila Burute et al.   Annual Review of Cell and Developmental Biology

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Microtubule-Associated Proteins: Structuring the Cytoskeleton

(2019) Satish Bodakuntla et al.   TRENDS IN CELL BIOLOGY

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis

(2018) Carla G. Silva et al.   CELL

SnapShot: Functions of Tubulin Posttranslational Modifications

(2018) Maria M. Magiera et al.   CELL

Motor axon navigation relies on Fidgetin-like 1–driven microtubule plus end dynamics

(2018) Coralie Fassier et al.   JOURNAL OF CELL BIOLOGY

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors

(2018) Rodrigo Muñoz-Castañeda et al.   Scientific Reports

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration

(2018) Vandana Shashi et al.   EMBO JOURNAL

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

(2018) Maria M Magiera et al.   EMBO JOURNAL

Microtubule-severing enzymes: From cellular functions to molecular mechanism

(2018) Francis J. McNally et al.   JOURNAL OF CELL BIOLOGY

CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice

(2018) Stephen Gilmore-Hall et al.   JOURNAL OF CELL BIOLOGY

Effects of mutating α-tubulin lysine 40 on sensory dendrite development

(2017) Brian V. Jenkins et al.   JOURNAL OF CELL SCIENCE

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

(2017) Kurt J. De Vos et al.   NEUROBIOLOGY OF DISEASE

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

(2017) Scott T. Brady et al.   NEUROBIOLOGY OF DISEASE

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases

(2017) Hong Joo Kim et al.   NEURON

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

(2017) Scott A. Small et al.   TRENDS IN NEUROSCIENCES

The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory

(2017) Sarah Perry et al.   Cell Reports

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

Mutations modifying sporadic Alzheimer's disease age of onset

(2016) Jorge I. Vélez et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease

(2016) Soumyananda Chakraborti et al.   Cytoskeleton

A method for integrating neuroimaging into genetic models of learning performance

(2016) Chintan M. Mehta et al.   GENETIC EPIDEMIOLOGY

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused byTTLL5mutations

(2016) Xun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Posttranslational modifications of α-tubulin in alzheimer disease

(2015) Fan Zhang et al.   Translational Neurodegeneration

C-terminomics Screen for Natural Substrates of Cytosolic Carboxypeptidase 1 Reveals Processing of Acidic Protein C termini

(2014) Sebastian Tanco et al.   MOLECULAR & CELLULAR PROTEOMICS

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

(2014) Olivia Tort et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Gephyrin: a master regulator of neuronal function?

(2014) Shiva K. Tyagarajan et al.   NATURE REVIEWS NEUROSCIENCE

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

It cuts two ways: microtubule loss during Alzheimer disease

(2013) Daphney C Jean et al.   EMBO JOURNAL

Cytosolic Carboxypeptidase 5 Removes α- and γ-Linked Glutamates from Tubulin

(2013) Iryna Berezniuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

A structural and functional analysis of Nna1 in Purkinje cell degeneration (pcd) mice

(2012) Hui-Yuan Wu et al.   FASEB JOURNAL

Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations

(2011) Max A Tischfield et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Purkinje Cell Degeneration inpcdMice Reveals Large Scale Chromatin Reorganization and Gene Silencing Linked to Defective DNA Repair

(2011) Fernando C. Baltanás et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Carboxypeptidase 1 Is Involved in Processing α- and β-Tubulin

(2011) Iryna Berezniuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons

(2011) K.Y. Lo et al.   NEUROSCIENCE LETTERS

Nucleolar Disruption and Cajal Body Disassembly are Nuclear Hallmarks of DNA Damage-Induced Neurodegeneration in Purkinje Cells

(2010) Fernando C. Baltanás et al.   BRAIN PATHOLOGY

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice

(2010) Iryna Berezniuk et al.   FASEB JOURNAL

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone

(2009) Séverine Marcos et al.   PLoS One

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

(2009) C. Maas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience