Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms

S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury

(2018) Hai-Bin Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway

(2018) Hang Wang et al.   CELL BIOLOGY INTERNATIONAL

Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation

(2018) Cui Zhai et al.   LIFE SCIENCES

Essential Role of Polo-like Kinase 1 (Plk1) Oncogene in Tumor Growth and Metastasis of Tamoxifen-Resistant Breast Cancer

(2018) Sung Baek Jeong et al.   MOLECULAR CANCER THERAPEUTICS

Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms

(2018) Yilin Pan et al.   Scientific Reports

STAT3 potentiates the ability of airway smooth muscle cells to promote angiogenesis by regulating VEGF signalling

(2017) Jing Lv et al.   EXPERIMENTAL PHYSIOLOGY

Sodium salicylate modulates inflammatory responses through AMP-activated protein kinase activation in LPS-stimulated THP-1 cells

(2017) Weiwei Bao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude mice

(2017) Matthew J. Nemec et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

(2017) Nitai C. Hait et al.   MEDIATORS OF INFLAMMATION

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

(2017) Jennifer Huynh et al.   SEMINARS IN CANCER BIOLOGY

Characteristics of the expression of the transcription factor pSTAT3 in asthma

(2017) V. N. Mineev et al.   TERAPEVTICHESKII ARKHIV

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

(2016) A. C. Gavino et al.   ALLERGY

Activation of AMPK α2 inhibits airway smooth muscle cells proliferation

(2016) Lu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein

(2016) Udhayakumar Gopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics

(2016) Rosie Elizabeth Ann Gutteridge et al.   MOLECULAR CANCER THERAPEUTICS

Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate

(2016) Fiorentina Roviezzo et al.   PHARMACOLOGICAL RESEARCH

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

Increased Expression of Phosphorylated Polo-Like Kinase 1 and Histone in Bypass Vein Graft and Coronary Arteries following Angioplasty

(2016) Swastika Sur et al.   PLoS One

The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator

(2015) Brandon Faubert et al.   CANCER LETTERS

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders

(2015) Luca Antonioli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation

(2015) Paradesi Naidu Gollavilli et al.   FEBS Journal

Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy

(2015) Kyung S. Lee et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

(2014) E. Fuerst et al.   ALLERGY

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension

(2014) Jiwang Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

STAT3 and metabolism: How many ways to use a single molecule?

(2014) Marco Demaria et al.   INTERNATIONAL JOURNAL OF CANCER

Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids

(2013) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of Airway Remodeling

(2013) Nobuaki Hirota et al.   CHEST

Sphingosine 1-phosphate signalling

(2013) K. Mendelson et al.   DEVELOPMENT

Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure

(2012) Harry Karmouty-Quintana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity

(2012) Weifang Yu et al.   ATHEROSCLEROSIS

Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase

(2012) Chan Sun Park et al.   BIOCHEMICAL PHARMACOLOGY

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Correction: Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway

(2012) Kenneth C. Loh et al.   PLoS One

Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells

(2011) Yu Zhang et al.   GASTROENTEROLOGY

Targeting Polo-like Kinase in Cancer Therapy

(2010) Y. Degenhardt et al.   CLINICAL CANCER RESEARCH

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)

(2010) A. Nerstedt et al.   DIABETOLOGIA

Airway remodeling is correlated with obstruction in children with severe asthma

(2008) I. Tillie-Leblond et al.   ALLERGY

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model

(2008) Teruaki Nishiuma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

Sphingosine-1-phosphate regulation of mammalian development

(2008) M KONO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Airway Remodeling Measured by Multidetector CT Is Increased in Severe Asthma and Correlates With Pathology

(2008) Ravi S. Aysola et al.   CHEST