BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

The structural basis for cohesin–CTCF-anchored loops

(2020) Yan Li et al.   NATURE

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

(2020) Robert T. Wimbish et al.   Frontiers in Cell and Developmental Biology

The structure of the Ctf19c/CCAN from budding yeast

(2019) Stephen M Hinshaw et al.   eLife

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

(2019) Amal Alex et al.   eLife

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

(2019) Kaige Yan et al.   NATURE

The kinetochore–microtubule interface at a glance

(2018) Julie K. Monda et al.   JOURNAL OF CELL SCIENCE

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

(2018) Marion E. Pesenti et al.   MOLECULAR CELL

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

(2018) Vladimir Joukov et al.   Science Signaling

Playing polo during mitosis: PLK1 takes the lead

(2017) G Combes et al.   ONCOGENE

Decoding the centromeric nucleosome through CENP-N

(2017) Satyakrishna Pentakota et al.   eLife

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

(2017) Dongqing Pan et al.   eLife

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

(2017) Ana Maria G Dumitru et al.   eLife

Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis

(2017) Masanori Ikeda et al.   Scientific Reports

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Insights from biochemical reconstitution into the architecture of human kinetochores

(2016) John R. Weir et al.   NATURE

Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

(2016) Robert F Lera et al.   Nature Chemical Biology

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity

(2016) Kang Zhu et al.   STRUCTURE

The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

(2016) Luying Jia et al.   Nature Communications

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

(2016) Anna P Baron et al.   eLife

Molecular basis of outer kinetochore assembly on CENP-T

(2016) Pim J Huis in 't Veld et al.   eLife

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis

(2015) Xiaolong Zhuo et al.   JOURNAL OF CELL BIOLOGY

The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores

(2015) Ho-Soo Lee et al.   Nature Communications

Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation

(2015) Hengyi Shao et al.   Scientific Reports

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

(2015) Aisling O'Connor et al.   Biology Open

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1

(2015) Claudia Breit et al.   PLoS One

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres

(2014) Kara L. McKinley et al.   CELL

Cohesin and Its Regulation: On the Logic of X-Shaped Chromosomes

(2014) Judith H.I. Haarhuis et al.   DEVELOPMENTAL CELL

A Microtubule-Associated Zinc Finger Protein, BuGZ, Regulates Mitotic Chromosome Alignment by Ensuring Bub3 Stability and Kinetochore Targeting

(2014) Hao Jiang et al.   DEVELOPMENTAL CELL

CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment

(2014) M. A. Amin et al.   JOURNAL OF CELL SCIENCE

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization

(2014) Arsen Petrovic et al.   MOLECULAR CELL

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

(2014) Yves Matthess et al.   Molecular Oncology

Mechanisms Underlying Plk1 Polo-Box Domain-Mediated Biological Processes and Their Physiological Significance

(2014) Kyung S. Lee et al.   MOLECULES AND CELLS

Meikin is a conserved regulator of meiosis-I-specific kinetochore function

(2014) Jihye Kim et al.   NATURE

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The condensin component NCAPG2 regulates microtubule–kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores

(2014) Jae Hyeong Kim et al.   Nature Communications

Phospho-H2A and Cohesin Specify Distinct Tension-Regulated Sgo1 Pools at Kinetochores and Inner Centromeres

(2013) Hong Liu et al.   CURRENT BIOLOGY

KI Motifs of Human Knl1 Enhance Assembly of Comprehensive Spindle Checkpoint Complexes around MELT Repeats

(2013) Veronica Krenn et al.   CURRENT BIOLOGY

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit

(2013) Ting-Yu Yeh et al.   EMBO JOURNAL

The functions and consequences of force at kinetochores

(2013) Florencia Rago et al.   JOURNAL OF CELL BIOLOGY

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity

(2013) Gina V. Caldas et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment

(2013) Toyoaki Natsume et al.   MOLECULAR CELL

Determinants of robustness in spindle assembly checkpoint signalling

(2013) Stephanie Heinrich et al.   NATURE CELL BIOLOGY

Structural basis for the inhibition of Polo-like kinase 1

(2013) Jun Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death

(2013) D S O'Donovan et al.   Cell Death & Disease

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

(2013) Iain M. Porter et al.   Nature Communications

Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis

(2012) Shao-Chen Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Mps1 promotes rapid centromere accumulation of Aurora B

(2012) Maike S van der Waal et al.   EMBO REPORTS

Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments

(2012) Ana R.R. Maia et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase-1 regulates kinetochore–microtubule dynamics and spindle checkpoint silencing

(2012) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments

(2012) T. Moutinho-Santos et al.   JOURNAL OF CELL SCIENCE

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres

(2012) Mar Carmena et al.   PLOS BIOLOGY

Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase

(2011) Valérie Lobjois et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

(2011) Fangwei Wang et al.   CURRENT BIOLOGY

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

(2011) M Teresa Bertran et al.   EMBO JOURNAL

Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores

(2011) Young H. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

(2011) Zhen Dou et al.   PLoS One

Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes

(2011) B. Hegemann et al.   Science Signaling

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Polo-box domain: a versatile mediator of polo-like kinase function

(2010) Jung-Eun Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulated protein kinases and phosphatases in cell cycle decisions

(2010) Bela Novak et al.   CURRENT OPINION IN CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

(2010) Arsen Petrovic et al.   JOURNAL OF CELL BIOLOGY

Molecular control of kinetochore-microtubule dynamics and chromosome oscillations

(2010) Ana C. Amaro et al.   NATURE CELL BIOLOGY

Sister chromatid tension and the spindle assembly checkpoint

(2009) Luigi Nezi et al.   CURRENT OPINION IN CELL BIOLOGY

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1

(2009) S. Elowe et al.   JOURNAL OF CELL SCIENCE

Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the  TuRC to the centrosome

(2009) X. Zhang et al.   JOURNAL OF CELL SCIENCE

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

(2009) Mark E. Burkard et al.   PLOS BIOLOGY

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

(2009) Benjamin A. Wolfe et al.   PLOS BIOLOGY

Establishment of Cohesion at the Pericentromere by the Ctf19 Kinetochore Subcomplex and the Replication Fork-Associated Factor, Csm3

(2009) Josefin Fernius et al.   PLoS Genetics

Plk1 Activation by Ste20-like Kinase (Slk) Phosphorylation and Polo-Box Phosphopeptide Binding Assayed with the Substrate Translationally Controlled Tumor Protein (TCTP)†

(2008) Tim M. Johnson et al.   BIOCHEMISTRY

Molecular Basis of Drug Resistance in Aurora Kinases

(2008) Fiona Girdler et al.   CHEMISTRY & BIOLOGY

Myosin Phosphatase-Targeting Subunit 1 Regulates Mitosis by Antagonizing Polo-like Kinase 1

(2008) Shigeko Yamashiro et al.   DEVELOPMENTAL CELL

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

(2008) Alexander W. Bird et al.   JOURNAL OF CELL BIOLOGY

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

(2008) Haomin Huang et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE