Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn’s Disease Phenotypes in Southeastern Brazilians

Two-stage Genome-wide Methylation Profiling in Childhood-onset Crohnʼs Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci

(2014) Alex T. Adams et al.   INFLAMMATORY BOWEL DISEASES

Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort

(2014) Steffen Bank et al.   PLoS One

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

Association Study of 71 European Crohnʼs Disease Susceptibility Loci in a Japanese Population

(2013) Atsushi Hirano et al.   INFLAMMATORY BOWEL DISEASES

Revisiting the Genetic Ancestry of Brazilians Using Autosomal AIM-Indels

(2013) Fernanda Saloum de Neves Manta et al.   PLoS One

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

(2012) Isabelle Cleynen et al.   GUT

Common NOD2 risk variants in African Americans with Crohnʼs disease are due exclusively to recent Caucasian admixture

(2012) Oloruntosin Adeyanju et al.   INFLAMMATORY BOWEL DISEASES

Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort

(2012) Chaolan Lv et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population

(2012) Lan Chen   WORLD JOURNAL OF GASTROENTEROLOGY

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

(2012) Eimear E. Kenny et al.   PLoS Genetics

Evaluation of 22 genetic variants with Crohn's Disease risk in the Ashkenazi Jewish population: a case-control study

(2011) Inga Peter et al.   BMC Medical Genetics

TLE1 Modifies the Effects of NOD2 in the Pathogenesis of Crohn's Disease

(2011) Elaine R. Nimmo et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

(2011) W Strober et al.   Mucosal Immunology

The Genomic Ancestry of Individuals from Different Geographical Regions of Brazil Is More Uniform Than Expected

(2011) Sérgio D. J. Pena et al.   PLoS One

Genomic Ancestry, Self-Reported “Color” and Quantitative Measures of Skin Pigmentation in Brazilian Admixed Siblings

(2011) Tailce K. M. Leite et al.   PLoS One

Commensal flora and the regulation of inflammatory and autoimmune responses

(2011) Jan Kranich et al.   SEMINARS IN IMMUNOLOGY

Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics

(2010) B. E. Stranger et al.   GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs

(2009) Tulio C. Lins et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

MDP-Induced selective tolerance to TLR4 ligands: Impairment in NOD2 mutant Crohnʼs disease patients

(2009) Elisabet Cantó et al.   INFLAMMATORY BOWEL DISEASES

Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

(2009) Arunan S. Vamadevan et al.   Innate Immunity

The role of innate signaling in the homeostasis of tolerance and immunity in the intestine

(2009) Jerry M. Wells et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Identification ofNOD2/CARD15mutations in Malaysian patients with Crohn's disease

(2009) Kek Heng CHUA et al.   Journal of Digestive Diseases

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohnʼs disease in an Australian population

(2008) Georgia E. Hume et al.   INFLAMMATORY BOWEL DISEASES

CARD15 and IL23R influences Crohnʼs disease susceptibility but not disease phenotype in a Brazilian population

(2008) Márcia Luiza Baptista et al.   INFLAMMATORY BOWEL DISEASES

Immune Response and Gene Polymorphism Profiles in Crohnʼs Disease and Ulcerative Colitis

(2008) Dulciene Maria Magalhães Queiroz et al.   INFLAMMATORY BOWEL DISEASES

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

(2008) Luciana Rigoli et al.   WORLD JOURNAL OF GASTROENTEROLOGY

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

(2007) Christopher G. Mathew   NATURE REVIEWS GENETICS