NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

 -PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2

(2014) J. Eitel et al.   JOURNAL OF IMMUNOLOGY

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

(2014) J. G. Magalhaes et al.   JOURNAL OF IMMUNOLOGY

NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

(2014) M. Divangahi et al.   JOURNAL OF IMMUNOLOGY

Adherent-invasive E. coli in Crohn disease: bacterial “agent provocateur”

(2011) Warren Strober   JOURNAL OF CLINICAL INVESTIGATION

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance

(2011) Tanja Petnicki-Ocwieja et al.   PLoS One

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

(2010) Matija Hedl et al.   GASTROENTEROLOGY

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF- B Signaling

(2010) C. Toma et al.   JOURNAL OF IMMUNOLOGY

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

(2010) A. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

(2009) MingFang Tao et al.   CURRENT BIOLOGY

Multiple regulatory and effector roles of autophagy in immunity

(2009) Vojo Deretic   CURRENT OPINION IN IMMUNOLOGY

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses

(2009) Warren Strober   IMMUNITY

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased NOD2-mediated recognition ofN-glycolyl muramyl dipeptide

(2009) François Coulombe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A function for AAMP in Nod2-mediated NF-κB activation

(2009) H. Bielig et al.   MOLECULAR IMMUNOLOGY

Nucleotide oligomerization domain-2 interacts with 2′-5′-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells

(2009) Jae W. Dugan et al.   MOLECULAR IMMUNOLOGY

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1

(2009) Eiichiro Noguchi et al.   NATURE IMMUNOLOGY

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

(2009) Michael H Shaw et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

NOD2 contributes to cutaneous defense against Staphylococcus aureus through  -toxin-dependent innate immune activation

(2009) P. Hruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

(2009) Kenichi Shimada et al.   PLoS Pathogens

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

MEKK4 Sequesters RIP2 to Dictate NOD2 Signal Specificity

(2008) Nivedita M. Clark et al.   CURRENT BIOLOGY

A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis

(2008) Monica Boirivant et al.   GASTROENTEROLOGY

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells

(2008) Noriyuki Hirata et al.   MOLECULAR IMMUNOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

(2008) Jess H. Leber et al.   PLoS Pathogens

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of NOD2 has a dual effect on proIL-1β mRNA transcription and secretion of bioactive IL-1β

(2007) Gerben Ferwerda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crohn’s disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

(2007) Bart Jan Kullberg et al.   IMMUNOLOGY