Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling

Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway

(2019) Ji Pan et al.   TOXICOLOGY IN VITRO

Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage

(2019) Marc Durocher et al.   Journal of Neuroinflammation

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

(2019) Hideaki Tanaka et al.   JOURNAL OF CELL SCIENCE

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

(2019) Nikhil Panicker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice

(2019) Yongkang Fang et al.   Journal of Neuroinflammation

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness

(2019) Mengmeng Xu et al.   FREE RADICAL RESEARCH

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

(2019) Yan-Hua Li et al.   Journal of Neuroinflammation

Quantifying blood-brain-barrier leakage using a combination of evans blue and high molecular weight FITC-Dextran

(2019) Yangyang Xu et al.   JOURNAL OF NEUROSCIENCE METHODS

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

(2019) He et al.   Cells

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

(2019) Chao Cao et al.   Cell Death & Disease

Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

(2018) Shaunik Sharma et al.   NEUROBIOLOGY OF DISEASE

Injury mechanisms in acute intracerebral hemorrhage

(2018) D. Andrew Wilkinson et al.   NEUROPHARMACOLOGY

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

(2018) Yi-Tong Lu et al.   Cell Death & Disease

AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission

(2018) Kyle H. Flippo et al.   JOURNAL OF NEUROSCIENCE

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications

(2018) Pranesh Kumar et al.   LIFE SCIENCES

Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway

(2018) Jie Cao et al.   NEUROBIOLOGY OF DISEASE

Crashing the computer: apoptosis vs. necroptosis in neuroinflammation

(2018) Bradlee L. Heckmann et al.   CELL DEATH AND DIFFERENTIATION

Programmed Cell Death after Intracerebral Hemorrhage

(2018) Tobias Bobinger et al.   Current Neuropharmacology

TOM7 silencing exacerbates focal cerebral ischemia injury in rat by targeting PINK1/Beclin1-mediated autophagy

(2018) Jiang Ning et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis

(2017) Fucheng Luo et al.   EXPERIMENTAL NEUROLOGY

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes

(2017) Chingli Lee et al.   Scientific Reports

Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus

(2016) Shang-Der Chen et al.   CNS Neuroscience & Therapeutics

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

(2016) Shouji Matsushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxo1-mediated inflammatory response after cerebral hemorrhage in rats

(2016) Zhenyu Li et al.   NEUROSCIENCE LETTERS

Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation

(2015) L. An et al.   GENETICS AND MOLECULAR RESEARCH

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death

(2014) Ivan Zaja et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory outcomes of apoptosis, necrosis and necroptosis

(2014) Pavel Davidovich et al.   BIOLOGICAL CHEMISTRY

Fyn Kinases Play a Critical Role in Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation or Amyloid-β Peptide Treatment

(2012) Cai-Ping Du et al.   CNS Neuroscience & Therapeutics

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia–ischemia in mice with neuronal Fyn overexpression

(2012) Renatta Knox et al.   NEUROBIOLOGY OF DISEASE

Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote pkcδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model

(2011) Hariharan Saminathan et al.   NEUROTOXICOLOGY

Src family kinases: modulators of neurotransmitter receptor function and behavior

(2011) Hiroshi Ohnishi et al.   TRENDS IN NEUROSCIENCES

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

(2010) Charlotte JJ van Asch et al.   LANCET NEUROLOGY

Preclinical and clinical research on inflammation after intracerebral hemorrhage

(2010) Jian Wang   PROGRESS IN NEUROBIOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Incidence and 10-Year Survival of Intracerebral Hemorrhage in a Population-Based Registry

(2008) Simona Sacco et al.   STROKE