Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal Models

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis

(2020) Mahtab Ghadiri et al.   Scientific Reports

Event-Driven Immunoprofiling Predicts Return of Disease Activity in Alemtuzumab-Treated Multiple Sclerosis

(2020) Katja Akgün et al.   Frontiers in Immunology

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

(2020) Nina L Fransen et al.   BRAIN

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients

(2019) Silvia Medina et al.   Annals of Clinical and Translational Neurology

The Diversity of Encephalitogenic CD4+ T Cells in Multiple Sclerosis and Its Animal Models

(2019) Benjamin Segal   Journal of Clinical Medicine

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Current therapeutic landscape in multiple sclerosis

(2019) Bruce A.C. Cree et al.   CURRENT OPINION IN NEUROLOGY

Communication of CD 8 + T cells with mononuclear phagocytes in multiple sclerosis

(2019) Matea Konjevic Sabolek et al.   Annals of Clinical and Translational Neurology

Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis

(2019) Eduardo Beltrán et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing T cell responses in experimental autoimmune encephalomyelitis

(2019) Naresha Saligrama et al.   NATURE

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Anti-CD20 therapy depletes activated myelin-specific CD8+T cells in multiple sclerosis

(2019) Joseph J. Sabatino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

(2019) Leslie Kirby et al.   Nature Communications

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

(2019) Christina Lückel et al.   Nature Communications

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid—Results from the ToFingo Successor Study

(2018) Lisa Lohmann et al.   Frontiers in Immunology

Deconstructing and targeting the genomic architecture of human neurodegeneration

(2018) Philip L. De Jager et al.   NATURE NEUROSCIENCE

Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis

(2018) Marina R von Essen et al.   BRAIN

Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up

(2018) Maxi Kaufmann et al.   Frontiers in Neurology

Optimal response to dimethyl fumarate associates in MS with a shift from an inflammatory to a tolerogenic blood cell profile

(2017) Silvia Medina et al.   Multiple Sclerosis Journal

Interpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab

(2017) David Baker et al.   JAMA Neurology

Optimal response to dimethyl fumarate associates in MS with a shift from an inflammatory to a tolerogenic blood cell profile

(2017) Silvia Medina et al.   Multiple Sclerosis Journal

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update

(2016) Kassandra Munger et al.   SEMINARS IN NEUROLOGY

Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis

(2016) Xiaohua Wang et al.   Scientific Reports

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis

(2015) A. Harrer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Classification, diagnosis, and differential diagnosis of multiple sclerosis

(2015) Ilana Katz Sand   CURRENT OPINION IN NEUROLOGY

Involvement of CD8+ T Cells in Multiple Sclerosis

(2015) Marion Salou et al.   Frontiers in Immunology

Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?

(2015) Romana Höftberger et al.   Acta Neuropathologica Communications

Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells

(2014) Khrishen Cunnusamy et al.   CLINICAL IMMUNOLOGY

Stage-Specific Immune Dysregulation in Multiple Sclerosis

(2014) Benjamin M. Segal   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lymphocytes with Cytotoxic Activity Induce Rapid Microtubule Axonal Destabilization Independently and before Signs of Neuronal Death

(2013) Nichole M. Miller et al.   ASN Neuro

CD8+T cells in multiple sclerosis

(2013) Aleksandar Denic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Intrathecal Soluble HLA-E Correlates with Disease Activity in Patients with Multiple Sclerosis and may Cooperate with Soluble HLA-G in the Resolution of Neuroinflammation

(2013) Fabio Morandi et al.   Journal of Neuroimmune Pharmacology

Fingolimod Modulates Peripheral Effector and Regulatory T Cells in MS Patients

(2013) Laura D. Serpero et al.   Journal of Neuroimmune Pharmacology

HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients

(2013) Kim Pannemans et al.   Multiple Sclerosis Journal

CD8+ T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease

(2013) Andrew F. Tyler et al.   PLoS One

Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8+regulatory cells

(2012) Yunliang Yao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

(2012) Magdalena Huber et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis

(2012) Timothy W Phares et al.   Journal of Neuroinflammation

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

(2011) A. Saxena et al.   FEBS LETTERS

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

CXCL16 and CXCR6 Are Upregulated in Psoriasis and Mediate Cutaneous Recruitment of Human CD8+ T Cells

(2011) Claudia Günther et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Natalizumab (Tysabri)

(2010) D.T. Selewski et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

CD8+Foxp3+ T cells in peripheral blood of relapsing-remitting multiple sclerosis patients

(2010) Giovanni Frisullo et al.   HUMAN IMMUNOLOGY

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions

(2009) G. L. Suidan et al.   JOURNAL OF IMMUNOLOGY

Role of the innate immune system in the pathogenesis of multiple sclerosis

(2009) Roopali Gandhi et al.   JOURNAL OF NEUROIMMUNOLOGY

Demyelinated Axons and Motor Function Are Protected by Genetic Deletion of Perforin in a Mouse Model of Multiple Sclerosis

(2009) Chandra Deb et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Blood CD8+T cell responses against myelin determinants in multiple sclerosis and healthy individuals

(2008) Laureline Berthelot et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis

(2008) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells

(2008) Georgette L. Suidan et al.   PLoS One

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY