A 2020 View of Thymus Stromal Cells in T Cell Development

Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration

(2020) Maude Dumont-Lagacé et al.   Frontiers in Immunology

Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage

(2020) Michael Ly Hun et al.   Frontiers in Immunology

Fibroblasts as a source of self-antigens for central immune tolerance

(2020) Takeshi Nitta et al.   NATURE IMMUNOLOGY

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells

(2019) Brian M. Larsen et al.   JOURNAL OF IMMUNOLOGY

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

(2019) Edward L. Y. Chen et al.   NATURE IMMUNOLOGY

Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration

(2019) Thomas Venables et al.   Nature Communications

Cellularity of Thymic Epithelial Cells in the Postnatal Mouse

(2018) Mie Sakata et al.   JOURNAL OF IMMUNOLOGY

Fundamental parameters of the developing thymic epithelium in the mouse

(2018) Mayumi Hirakawa et al.   Scientific Reports

Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity

(2018) Gordana Momčilo Leposavić et al.   Frontiers in Endocrinology

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development

(2018) María J. García-León et al.   DEVELOPMENT

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

Thymus machinery for T-cell selection

(2018) Kenta Kondo et al.   INTERNATIONAL IMMUNOLOGY

Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

(2018) Jianwei Wang et al.   INTERNATIONAL IMMUNOLOGY

Essential role of CCL21 in establishment of central self-tolerance in T cells

(2017) Mina Kozai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

(2017) Muhammad Myn Uddin et al.   Nature Communications

Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment

(2017) Jeremy B. Swann et al.   Scientific Reports

Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing

(2016) Martti Laan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

(2016) Mario Buono et al.   NATURE CELL BIOLOGY

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration

(2016) Yaoyao Shi et al.   Nature Communications

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

(2016) Kathy E. O’Neill et al.   PLoS One

Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus

(2015) Immanuel Rode et al.   JOURNAL OF IMMUNOLOGY

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

(2015) Amine Boudil et al.   NATURE IMMUNOLOGY

FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells

(2015) Lina Sun et al.   Scientific Reports

Regeneration of the aged thymus by a single transcription factor

(2014) N. Bredenkamp et al.   DEVELOPMENT

Neural Crest Origin of Perivascular Mesenchyme in the Adult Thymus

(2014) S. M. Muller et al.   JOURNAL OF IMMUNOLOGY

Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus

(2014) K. Foster et al.   JOURNAL OF IMMUNOLOGY

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

(2014) Nicholas Bredenkamp et al.   NATURE CELL BIOLOGY

Conversion of the Thymus into a Bipotent Lymphoid Organ by Replacement of Foxn1 with Its Paralog, Foxn4

(2014) Jeremy B. Swann et al.   Cell Reports

IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR  + Intraepithelial Lymphocytes

(2013) S. Shitara et al.   JOURNAL OF IMMUNOLOGY

Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus

(2013) Cyrille Ramond et al.   NATURE IMMUNOLOGY

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

(2012) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations

(2012) S. Tani-ichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis

(2011) J. Shi et al.   BLOOD

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

(2011) I. Van de Walle et al.   BLOOD

Mechanisms of thymus organogenesis and morphogenesis

(2011) J. Gordon et al.   DEVELOPMENT

The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling

(2011) Roxane Tussiwand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structure and function of the thymic microenvironment

(2011) Nancy Ruth Manley   Frontiers in Bioscience-Landmark

Notch3 Is Dispensable for Thymocyte β-Selection and Notch1-Induced T Cell Leukemogenesis

(2011) Sara Suliman et al.   PLoS One

Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus

(2011) L. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence

(2011) Craig S. Nowell et al.   PLoS Genetics

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

(2009) D. A. Zlotoff et al.   BLOOD

CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus

(2009) A. Krueger et al.   BLOOD

Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25

(2009) Klaus Gossens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

Characterization of the thymic IL-7 niche in vivo

(2009) N. L. Alves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delta-like 4 is indispensable in thymic environment specific for T cell development

(2008) Katsuto Hozumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

(2008) Ute Koch et al.   JOURNAL OF EXPERIMENTAL MEDICINE