Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin

(2020) Toshiyuki Oda et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cardiac muscle thin filament structures reveal calcium regulatory mechanism

(2020) Yurika Yamada et al.   Nature Communications

Protein-protein docking reveals dynamic interactions of tropomyosin on actin filaments

(2020) Elumalai Pavadai et al.   BIOPHYSICAL JOURNAL

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments

(2020) Matthew H. Doran et al.   BIOPHYSICAL JOURNAL

TNNT2mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction

(2020) Aditi Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Troponin Revealed: Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle

(2020) Larry S. Tobacman   BIOPHYSICAL JOURNAL

Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments

(2019) Elumalai Pavadai et al.   BIOPHYSICAL JOURNAL

Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype

(2018) Svetlana Tikunova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

(2018) Carolyn Y. Ho et al.   CIRCULATION

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

(2017) Binnu Gangadharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

(2016) Roddy Walsh et al.   GENETICS IN MEDICINE

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

(2016) Alexey V. Dvornikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation

(2016) Wenjun Zheng et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

(2016) Jalal K. Siddiqui et al.   Frontiers in Physiology

The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms

(2015) Sampath K. Gollapudi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

(2015) Ahmed A. Alfares et al.   GENETICS IN MEDICINE

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

(2015) Yuanhua Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Effects of Familial Hypertrophic Cardiomyopathy-Related Mutations in the TNT1 Domain of cTnT

(2012) Edward P. Manning et al.   JOURNAL OF MOLECULAR BIOLOGY

Thin Filament Mutations

(2011) Jil C. Tardiff   CIRCULATION RESEARCH

Inherited Cardiomyopathies

(2011) Hugh Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Localization of the two tropomyosin-binding sites of troponin T

(2010) J.-P. Jin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

(2008) K. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA