Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

Microenvironmental Signatures Reveal Biological Subtypes of Diffuse Large B-Cell Lymphoma (DLBCL) Distinct from Tumor Cell Molecular Profiling

(2020) Leandro Cerchietti et al.   BLOOD

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

(2020) Daisuke Ennishi et al.   NATURE MEDICINE

A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

(2020) George W. Wright et al.   CANCER CELL

Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

(2020) Wendy Béguelin et al.   CANCER CELL

FCRL5+ Memory B Cells Exhibit Robust Recall Responses

(2019) Charles C. Kim et al.   Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis

(2019) Michelle A. Mintz et al.   IMMUNITY

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

(2018) Ismail Sayin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

(2018) Simon Le Gallou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Many Th Cell Subsets Have Fas Ligand–Dependent Cytotoxic Potential

(2018) Dmitri I. Kotov et al.   JOURNAL OF IMMUNOLOGY

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

(2018) Roland Schmitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Controls Follicular T Helper Cell Positioning and Function

(2018) Jingwen Shi et al.   IMMUNITY

Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging

(2018) Isabelle Stewart et al.   IMMUNITY

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

(2018) Sarah E. Arthur et al.   Nature Communications

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

(2018) Carolyn E. Rydyznski et al.   Cell Reports

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

(2018) Daisuke Ennishi et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy

(2018) Chulin Sha et al.   JOURNAL OF CLINICAL ONCOLOGY

Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation

(2017) Jared Silver et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells

(2017) Brian J. Laidlaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

(2017) Peiwen Lu et al.   SCIENCE

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

(2016) Masayuki Kuraoka et al.   IMMUNITY

Peyer's patches: organizing B-cell responses at the intestinal frontier

(2016) Andrea Reboldi et al.   IMMUNOLOGICAL REVIEWS

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

(2016) F. Scherer et al.   Science Translational Medicine

Germinal Center Quality Control: Death by Fas

(2015) Christopher D.C. Allen   IMMUNITY

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

(2015) Danyal Butt et al.   IMMUNITY

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

(2015) Roberto Di Niro et al.   IMMUNITY

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

(2015) Ryan M. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

(2015) Gregory M. Frank et al.   mBio

Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes

(2014) J. S. Weinstein et al.   BLOOD

Natural history of autoimmune lymphoproliferative syndrome associated withFASgene mutations

(2014) Susan Price et al.   BLOOD

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Fas ligand–mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

(2014) Shoukat Afshar-Sterle et al.   NATURE MEDICINE

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

(2013) R. D. Morin et al.   BLOOD

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

(2011) S.-E. Bentebibel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

(2008) Zhenyue Hao et al.   IMMUNITY

Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen

(2008) B. Alabyev et al.   INTERNATIONAL IMMUNOLOGY

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT