Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion

Tumour-Associated Macrophages (TAMs) in Colon Cancer and How to Reeducate Them

(2019) M. A. F. Yahaya et al.   Journal of Immunology Research

FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway

(2019) Piao Li et al.   JOURNAL OF IMMUNOLOGY

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer

(2019) Billy Samuel Hill et al.   SEMINARS IN CANCER BIOLOGY

Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape

(2019) Arsen Osipov et al.   Journal for ImmunoTherapy of Cancer

Adoptive CD8+ T cell therapy against cancer:Challenges and opportunities

(2019) Xiaotao Jiang et al.   CANCER LETTERS

Progranulin attenuates liver fibrosis by downregulating the inflammatory response

(2019) Wonbeak Yoo et al.   Cell Death & Disease

The lysosomal function of progranulin, a guardian against neurodegeneration

(2018) Daniel H. Paushter et al.   ACTA NEUROPATHOLOGICA

PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation

(2018) Xin Yao Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

(2018) Valeria Quaranta et al.   CANCER RESEARCH

Progranulin: A key player in autoimmune diseases

(2018) Jinlong Jian et al.   CYTOKINE

Progranulin as a therapeutic target for dementia

(2018) Daniela Galimberti et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

(2018) Yiting Wang et al.   Frontiers in Pharmacology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion

(2018) Peixin Dong et al.   Frontiers in Oncology

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

(2018) Zhi-Fa Wen et al.   Journal for ImmunoTherapy of Cancer

Increased expression of PGRN protein in follicular fluid and mRNA in granulosa cells in overweight patients with polycystic ovary syndrome

(2017) Danni Zhou et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

(2017) Xiaohui Zhang et al.   International Journal of Clinical Oncology

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape

(2017) Takuro Noguchi et al.   Cancer Immunology Research

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells

(2015) David A. Quigley et al.   Molecular Oncology

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4

(2014) Peng Zhao et al.   Cellular & Molecular Immunology

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity

(2014) Qingyun Tian   Frontiers in Bioscience-Landmark

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

(2013) E. A. Akbay et al.   Cancer Discovery

Structure, Function, and Mechanism of Progranulin; the Brain and Beyond

(2011) Huishi Toh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Progranulin: A growth factor, a novel TNFR ligand and a drug target

(2011) Chuan-ju Liu et al.   PHARMACOLOGY & THERAPEUTICS

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS