Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux

Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

(2020) Jianxia Wen et al.   Evidence-based Complementary and Alternative Medicine

TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance

(2020) Xiao-ming Jiang et al.   ACTA PHARMACOLOGICA SINICA

Cellular Mechanisms of Circulating Tumor Cells During Breast Cancer Metastasis

(2020) Han-A Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX

(2020) Kyung-Phil Ko et al.   ONCOGENE

Critical steps to tumor metastasis: alterations of tumor microenvironment and extracellular matrix in the formation of pre-metastatic and metastatic niche

(2020) Jianan Zhuyan et al.   Cell and Bioscience

NF-κB inhibitors in treatment and prevention of lung cancer

(2020) Rajan Radha Rasmi et al.   BIOMEDICINE & PHARMACOTHERAPY

CKLF1 Enhances Inflammation-mediated Carcinogenesis and Prevents Doxorubicin-induced Apoptosis via IL-6/STAT3 Signaling in HCC

(2019) Fan Zhu et al.   CLINICAL CANCER RESEARCH

Potential of Fatty Oils from Traditional Chinese Medicine in Cancer Therapy: A Review for Phytochemical, Pharmacological and Clinical Studies

(2019) Yanleng Huang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4

(2019) Chen Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Role of epigenetic mechanisms in cisplatin-induced toxicity

(2019) Júlia Coelho França Quintanilha et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization

(2019) Chen Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats

(2019) Qidi Ai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

IMM-H004 Therapy for Permanent Focal Ischemic Cerebral Injury via CKLF1/CCR4-mediated NLRP3 Inflammasome Activation

(2019) QI-DI AI et al.   Translational Research

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

(2019) Yu-Lin Su et al.   BLOOD

Kanglaite injection plus platinum-based chemotherapy for stage III/IV non-small cell lung cancer: A meta-analysis of 27 RCTs

(2019) Xiaoming Huang et al.   PHYTOMEDICINE

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

(2018) Claudia Allemani et al.   LANCET

Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway

(2018) Chendong Yang et al.   OncoTargets and Therapy

Propofol inhibits proliferation, migration and invasion of gastric cancer cells by up-regulating microRNA-195

(2018) Wenyu Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

LncRNA NKILA correlates with the malignant status and serves as a tumor-suppressive role in rectal cancer

(2018) Fei Tao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch

(2018) Liping Chen et al.   APOPTOSIS

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

(2018) Jie Fan et al.   Drug Design Development and Therapy

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

(2017) Seyung S. Chung et al.   MEDIATORS OF INFLAMMATION

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

(2017) Yijia Wang et al.   Scientific Reports

Role of chemokine pathways in hepatobiliary cancer

(2016) Josef Ehling et al.   CANCER LETTERS

Coix seed emulsion synergistically enhances the antitumor activity of gemcitabine in pancreatic cancer through abrogation of NF-κB signaling

(2016) Yafang Qian et al.   ONCOLOGY REPORTS

In vitro anti-cancer activities of Job’s tears (Coix lachryma-jobi Linn.) extracts on human colon adenocarcinoma

(2016) Aranya Manosroi et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Kanglaite stimulates anticancer immune responses and inhibits HepG2 cell transplantation-induced tumor growth

(2014) XINLI HUANG et al.   Molecular Medicine Reports

Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance

(2014) Nagaraju Anreddy et al.   MOLECULES

Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization

(2014) Zhen-Zhen Wang et al.   NEUROREPORT

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Chemokine-Like Factor 1 (CLFK1) Is Over-Expressed in Patients with Atopic Dermatitis

(2013) Gao-yun Yang et al.   International Journal of Biological Sciences

Effects of chemokine-like factor 1 on vascular smooth muscle cell migration and proliferation in vascular inflammation

(2012) Tao Zhang et al.   ATHEROSCLEROSIS

Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi

(2012) Yun Lu et al.   Hepatobiliary & Pancreatic Diseases International

Antitumor activity and immunomodulatory effects of the intraperitoneal administration of Kanglaite in vivo in Lewis lung carcinoma

(2012) Pei Pan et al.   JOURNAL OF ETHNOPHARMACOLOGY

ABCG2 transporter: therapeutic and physiologic implications in veterinary species

(2011) K. L. MEALEY   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy

(2011) Chung-Pu Wu et al.   MOLECULAR PHARMACEUTICS

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes

(2011) Yuta Yoshino et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma

(2010) L. Tian et al.   ALLERGY

NF-κB in the regulation of epithelial homeostasis and inflammation

(2010) Andy Wullaert et al.   CELL RESEARCH

Effect of NF-κB Signaling on Apoptosis in Chronic Inflammation-Associated Carcinogenesis

(2010) H. Wang et al.   CURRENT CANCER DRUG TARGETS

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

(2010) An-Kui Yang et al.   CURRENT MEDICINAL CHEMISTRY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

Cellular and molecular pathways linking inflammation and cancer

(2009) Chiara Porta et al.   IMMUNOBIOLOGY

Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients

(2009) Valerie Chew et al.   JOURNAL OF HEPATOLOGY

Inhibition of Coix seed extract on fatty acid synthase, a novel target for anticancer activity

(2008) Fei Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chinese herb related molecules of cancer-cell-apoptosis: a minireview of progress between Kanglaite injection and related genes

(2008) Yun Lu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH