Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

(2020) Yuki Matsushita et al.   Nature Communications

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow

(2019) Stefano Comazzetto et al.   Cell Stem Cell

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

(2019) Alexander Rauch et al.   NATURE GENETICS

Transcriptional and Epigenomic Regulation of Adipogenesis

(2019) Ji-Eun Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

(2019) David Merrick et al.   SCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths

(2019) Samuel L. Wolock et al.   Cell Reports

Congenital lipodystrophy induces severe osteosclerosis

(2019) Wei Zou et al.   PLoS Genetics

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

(2019) Chiara Baccin et al.   NATURE CELL BIOLOGY

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

(2018) Masanari Seike et al.   GENES & DEVELOPMENT

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles

(2018) Yiming Cheng et al.   Cell Reports

Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis

(2018) Russell T. Turner et al.   Current Osteoporosis Reports

Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis

(2018) Guojing Luo et al.   Frontiers in Endocrinology

Resting zone of the growth plate houses a unique class of skeletal stem cells

(2018) Koji Mizuhashi et al.   NATURE

Cre Recombinase Strains Used for the Study of Adipose Tissues and Adipocyte Progenitors

(2017) Jiaqi Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Gli1 identifies osteogenic progenitors for bone formation and fracture repair

(2017) Yu Shi et al.   Nature Communications

Bone marrow adipocytes

(2017) Mark C. Horowitz et al.   Adipocyte

CD90 a potential cancer stem cell marker and a therapeutic target

(2016) Muhammad Vaseem Shaikh et al.   Cancer Biomarkers

Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms

(2016) Abhishek Chandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Diabetes and Bone Marrow Adiposity

(2016) Tiffany Y. Kim et al.   Current Osteoporosis Reports

Increased Bone Marrow Adiposity in a Context of Energy Deficit: The Tip of the Iceberg?

(2016) Olfa Ghali et al.   Frontiers in Endocrinology

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse

(2015) Joohyun Lim et al.   DEVELOPMENT

MANAGEMENT OF ENDOCRINE DISEASE: Secondary osteoporosis: pathophysiology and management

(2015) Faryal Mirza et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Bone and fat: A relationship of different shades

(2014) Beata Lecka-Czernik et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PTH1–34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival

(2014) Abhishek Chandra et al.   BONE

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors

(2014) Laura E. Sidney et al.   STEM CELLS

Characterization of Cre recombinase models for the study of adipose tissue

(2014) Elise Jeffery et al.   Adipocyte

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow

(2012) Valerie A. Siclari et al.   BONE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population

(2008) Zana Kalajzic et al.   BONE

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell