Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy

Dysfunctional polycomb transcriptional repression contributes to lamin A/C–dependent muscular dystrophy

(2020) Andrea Bianchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial to Mesenchymal Transition in Cardiovascular Disease

(2019) Jason C. Kovacic et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

(2019) Nicolò Salvarani et al.   Nature Communications

Single-cell RNA-seq analysis of Mesp1-induced skeletal myogenic development

(2019) Jacqueline S. Penaloza et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arginine methylation‐dependent LSD1 stability promotes invasion and metastasis of breast cancer

(2019) Jiwei Liu et al.   EMBO REPORTS

The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks

(2018) Nolwenn Briand et al.   HUMAN MOLECULAR GENETICS

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

(2018) Yan Li et al.   Nature Reviews Cardiology

Lamin A/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation

(2017) Nina Eide Hasselberg et al.   EUROPEAN HEART JOURNAL

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Laminopathies disrupt epigenomic developmental programs and cell fate

(2016) Jelena Perovanovic et al.   Science Translational Medicine

Rebalancing gene haploinsufficiency in vivo by targeting chromatin

(2016) Filomena Gabriella Fulcoli et al.   Nature Communications

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

(2016) Imen Jebeniani et al.   Jove-Journal of Visualized Experiments

Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm

(2016) Sunny Sun-Kin Chan et al.   Stem Cell Reports

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

(2015) Elisa Cesarini et al.   JOURNAL OF CELL BIOLOGY

A detailed comparison of mouse and human cardiac development

(2014) Anita Krishnan et al.   PEDIATRIC RESEARCH

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

(2014) Giulia Mearini et al.   Nature Communications

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner

(2013) Sunny Sun-Kin Chan et al.   Cell Stem Cell

‘State-of-the-heart’ of cardiac laminopathies

(2013) Marie-Elodie Cattin et al.   CURRENT OPINION IN CARDIOLOGY

Lamin A/C is Expressed in Pluripotent Mouse Embryonic Stem Cells

(2013) Melanie A. Eckersley-Maslin et al.   Nucleus

Early cardiac development: a view from stem cells to embryos

(2012) P. Van Vliet et al.   CARDIOVASCULAR RESEARCH

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development

(2012) Stefan Bonn et al.   NATURE GENETICS

LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition

(2012) R. Baron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

(2011) Matthieu Rouleau et al.   STEM CELLS

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Posttranslational arginine methylation of lamin A/C during myoblast fusion

(2010) Su-Jin Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability

(2010) C. T. Foster et al.   MOLECULAR AND CELLULAR BIOLOGY

Mesp1 Coordinately Regulates Cardiovascular Fate Restriction and Epithelial-Mesenchymal Transition in Differentiating ESCs

(2008) R. Coleman Lindsley et al.   Cell Stem Cell