Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

Efficacy and tolerability of tirzepatide, a dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist in patients with type 2 diabetes: A 12‐week, randomized, double‐blind, placebo‐controlled study to evaluate different dose‐escalation regimens

(2020) Juan Pablo Frias et al.   DIABETES OBESITY & METABOLISM

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

(2020) Patrick Gilon   JOURNAL OF MOLECULAR BIOLOGY

Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes

(2020) Mark L. Hartman et al.   DIABETES CARE

Reductions in insulin resistance are mediated primarily via weight loss in subjects with type 2 diabetes on semaglutide

(2019) Vivian A Fonseca et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

980-P: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Patients

(2019) MELISSA K. THOMAS et al.   DIABETES

Proinsulin associates with poor β‐cell function, glucose‐dependent insulinotropic peptide, and insulin resistance in persistent type 2 diabetes after Roux‐en‐Y gastric bypass in humans

(2019) Kapila Patel et al.   Journal of Diabetes

Beta cell stress in a 4-year follow-up of patients with type 2 diabetes: A longitudinal analysis of the BetaDecline Study

(2018) Giuseppina T. Russo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

(2018) Clemens Wittenbecher et al.   DIABETES

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

(2018) Tamer Coskun et al.   Molecular Metabolism

Changes in inflammatory endometrial cancer risk biomarkers in individuals undergoing surgical weight loss

(2017) Faina Linkov et al.   GYNECOLOGIC ONCOLOGY

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain

(2016) Natalie J. Haywood et al.   DIABETES

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PREDICTS INSULIN SENSITIVITY AND INSULIN AREA-UNDER-THE-CURVE IN OBESE, NONDIABETIC ADOLESCENTS

(2016) Phillip D.K. Lee et al.   Endocrine Practice

Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial

(2015) Luigi Fontana et al.   AGING CELL

Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents

(2015) Thomas H. Inge et al.   JOURNAL OF PEDIATRICS

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men

(2015) Jagadish Vangipurapu et al.   PLoS One

Disruption of GIP/GIPR Axis in Human Adipose Tissue Is Linked to Obesity and Insulin Resistance

(2014) Victòria Ceperuelo-Mallafré et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Adiponectin, driver or passenger on the road to insulin sensitivity?

(2013) Risheng Ye et al.   Molecular Metabolism

Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

(2012) S. N. Rajpathak et al.   DIABETES

Upregulation of Plasma Insulin-Like Growth Factor Binding Protein 2 Levels After Biliopancreatic Diversion in Humans

(2012) Zhuo Li et al.   Obesity

GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis

(2012) Su-Jin Kim et al.   PLoS One

Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

(2011) R. C. Loopstra-Masters et al.   DIABETOLOGIA

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

(2010) Kristina Hedbacker et al.   Cell Metabolism

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

(2010) M N Harvie et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of Rosiglitazone and Ramipril on  -Cell Function in People With Impaired Glucose Tolerance or Impaired Fasting Glucose: The DREAM trial

(2009) A. J. Hanley et al.   DIABETES CARE

Rosiglitazone improves insulin sensitivity with increased serum leptin levels in patients with type 2 diabetes mellitus

(2008) Hae Jin Kim et al.   DIABETES RESEARCH AND CLINICAL PRACTICE