Landscape and flux quantify the stochastic transition dynamics for p53 cell fate decision

Curl Flux as a Dynamical Origin of the Bifurcations/Phase Transitions of Nonequilibrium Systems: Cell Fate Decision Making

(2020) Li Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

(2019) Dao-Guang Wang et al.   Scientific Reports

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision

(2019) Cheng-Yuan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Landscape and flux govern cellular mode-hopping between oscillations

(2019) Chunhe Li et al.   JOURNAL OF CHEMICAL PHYSICS

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest

(2018) José Reyes et al.   MOLECULAR CELL

Discrete flux and velocity fields of probability and their global maps in reaction systems

(2018) Anna Terebus et al.   JOURNAL OF CHEMICAL PHYSICS

Uncovering the underlying mechanism of cancer tumorigenesis and development under an immune microenvironment from global quantification of the landscape

(2017) Li Wenbo et al.   Journal of the Royal Society Interface

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

p53 dynamics orchestrates with binding affinity to target genes for cell fate decision

(2017) Mengqiu Wu et al.   Cell Death & Disease

Conservation and Divergence of p53 Oscillation Dynamics across Species

(2017) Jacob Stewart-Ornstein et al.   Cell Systems

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System

(2016) Beata Hat et al.   PLoS Computational Biology

Wip1 phosphatase in breast cancer

(2014) A Emelyanov et al.   ONCOGENE

Stem cell differentiation as a many-body problem

(2014) B. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape and flux reveal a new global view and physical quantification of mammalian cell cycle

(2014) Chunhe Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacodynamics of the p53-Mdm2 Targeting Drug Nutlin: The Role of Gene-Switching Noise

(2014) Krzysztof Puszynski et al.   PLoS Computational Biology

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths

(2013) Chunhe Li et al.   PLoS Computational Biology

Predicting rates of cell state change caused by stochastic fluctuations using a data-driven landscape model

(2012) D. R. Sisan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the Waddington landscape and biological paths for development and differentiation

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

(2009) Keng Boon Wee et al.   PLoS One

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oscillations and bistability in the stochastic model of p53 regulation

(2008) Krzysztof Puszyński et al.   JOURNAL OF THEORETICAL BIOLOGY

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Potential landscape and flux framework of nonequilibrium networks: Robustness, dissipation, and coherence of biochemical oscillations

(2008) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA