Controlled Fab-arm exchange for the generation of stable bispecific IgG1
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Title
Controlled Fab-arm exchange for the generation of stable bispecific IgG1
Authors
Keywords
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Journal
Nature Protocols
Volume 9, Issue 10, Pages 2450-2463
Publisher
Springer Nature America, Inc
Online
2014-09-25
DOI
10.1038/nprot.2014.169
References
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Related references
Note: Only part of the references are listed.- Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface
- (2014) Steven M Lewis et al. NATURE BIOTECHNOLOGY
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- (2013) Christian Kellner et al. METHODS
- A Heterodimeric Fc-Based Bispecific Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity
- (2013) H.-J. Choi et al. MOLECULAR CANCER THERAPEUTICS
- Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
- (2013) Christoph Spiess et al. NATURE BIOTECHNOLOGY
- Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
- (2013) A. F. Labrijn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair
- (2012) Pavel Strop et al. JOURNAL OF MOLECULAR BIOLOGY
- A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
- (2012) Gregory L. Moore et al. mAbs
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- (2012) Roland Kontermann mAbs
- Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength
- (2011) A. F. Labrijn et al. JOURNAL OF IMMUNOLOGY
- Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
- (2011) W. Schaefer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects
- (2010) Kannan Gunasekaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules
- (2010) Chengbin Wu et al. mAbs
- SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†
- (2010) Jonathan H. Davis et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Formulation Development of Antibodies Using Robotic System and High-Throughput Laboratory (HTL)
- (2009) Hui Zhao et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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