Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer’s Disease

(2019) Nkumbu L. Sikanyika et al.   NEUROCHEMICAL RESEARCH

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

β-Amyloid Peptide: the Cell Compartment Multi-faceted Interaction in Alzheimer’s Disease

(2019) Pasquale Picone et al.   NEUROTOXICITY RESEARCH

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

(2018) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ 1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

(2018) Mini P. Sajan et al.   NEUROBIOLOGY OF AGING

Long-term treadmill exercise attenuates Aβ burdens and astrocyte activation in APP/PS1 mouse model of Alzheimer’s disease

(2018) Jing Zhang et al.   NEUROSCIENCE LETTERS

Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

(2018) Igor V. Kurochkin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

(2018) Jean-Michel Paumier et al.   FASEB JOURNAL

Insulin-Like Growth Factor-1 Alleviates Expression of Aβ1–40 and α-, β-, and γ-Secretases in the Cortex and Hippocampus of APP/PS1 Double Transgenic Mice

(2018) Fangfang Song et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice

(2017) Kailin Yin et al.   NEUROLOGICAL RESEARCH

Berberine modulates amyloid-β peptide generation by activating AMP-activated protein kinase

(2017) Haijing Zhang et al.   NEUROPHARMACOLOGY

Metformin – a Future Therapy for Neurodegenerative Diseases

(2017) Magdalena Markowicz-Piasecka et al.   PHARMACEUTICAL RESEARCH

Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice

(2016) Huang Huang et al.   AGE

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

(2016) Pasquale Picone et al.   Aging-US

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

(2016) Inci Kazkayasi et al.   NEUROSCIENCE LETTERS

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice

(2014) Apostolia Fragkouli et al.   NEUROBIOLOGY OF DISEASE

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

(2013) Anita Stargardt et al.   AGING CELL

Evaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models

(2013) Maria Luisa de Lemos et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular links between Alzheimer’s disease and diabetes mellitus

(2013) Y. Yang et al.   NEUROSCIENCE

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA