High-content screening identifies a role for Na+channels in insulin production

High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function

(2015) Sean M. Burns et al.   Cell Metabolism

A live-cell, high-content imaging survey of 206 endogenous factors across five stress conditions reveals context-dependent survival effects in mouse primary beta cells

(2015) Yu Hsuan Carol Yang et al.   DIABETOLOGIA

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP

(2014) Qing Zhou et al.   Channels

Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression

(2014) Quan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Multiparameter Screening Reveals a Role for Na+Channels in Cytokine-Induced β-Cell Death

(2014) Yu Hsuan Carol Yang et al.   MOLECULAR ENDOCRINOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Carbamazepine as a Novel Small Molecule Corrector of Trafficking-impaired ATP-sensitive Potassium Channels Identified in Congenital Hyperinsulinism

(2013) Pei-Chun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-parameter single-cell kinetic analysis reveals multiple modes of cell death in primary pancreatic  -cells

(2013) Y. H. C. Yang et al.   JOURNAL OF CELL SCIENCE

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Regulation of β-cell function by RNA-binding proteins

(2013) Maria Grazia Magro et al.   Molecular Metabolism

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Maintenance of  -Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

(2012) M. Szabat et al.   DIABETES

Control of pancreatic β-cell fate by insulin signaling: The sweet spot hypothesis

(2011) James D Johnson et al.   CELL CYCLE

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

(2011) Y. H. C. Yang et al.   DIABETOLOGIA

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

(2011) Emilyn U. Alejandro et al.   FASEB JOURNAL

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

(2011) M Szabat et al.   Cell Death & Disease

Kinetics and genomic profiling of adult human and mouse β-cell maturation

(2011) Marta Szabat et al.   Islets

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Reciprocal modulation of adult beta cell maturity by activin A and follistatin

(2010) M. Szabat et al.   DIABETOLOGIA

A Multi-Parameter, High-Content, High-Throughput Screening Platform to Identify Natural Compounds that Modulate Insulin and Pdx1 Expression

(2010) Jessica A. Hill et al.   PLoS One

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY