Moderate Hypoxia Induces β-Cell Dysfunction with HIF-1–Independent Gene Expression Changes

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

VHL-mediated disruption of Sox9 activity compromises  -cell identity and results in diabetes mellitus

(2013) S. Puri et al.   GENES & DEVELOPMENT

Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage

(2013) Susana Peralta et al.   HUMAN MOLECULAR GENETICS

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Anks4b, a Novel Target of HNF4α Protein, Interacts with GRP78 Protein and Regulates Endoplasmic Reticulum Stress-induced Apoptosis in Pancreatic β-Cells

(2012) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

(2012) X Zheng et al.   Cell Death & Disease

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Chromatin as an oxygen sensor and active player in the hypoxia response

(2011) Andrew Melvin et al.   CELLULAR SIGNALLING

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretionin Vitro

(2011) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

(2010) Kei Fujimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA component of the hypoxic response

(2008) R Kulshreshtha et al.   CELL DEATH AND DIFFERENTIATION

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES

pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic   cells

(2008) J. Zehetner et al.   GENES & DEVELOPMENT

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE